Protein Alignment Ptp4E and PTPRU

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_005695.3
• Gene: PTPRU / 10076
• HGNCID: 9683
• Length: 1446
• Species: Homo sapiens
• Alignment Length: 1254
• Identity: 287/1254 - (22%)
• Similarity: 451/1254 - (35%)
• Gaps: 348/1254 - (27%)

  Fly   641 QAPEGSDFSEYVVRYRTDASPWQR----ISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPL 701
            :||.......|::...:..:|.||    ...|.||:.......|   :|     .|....||..|
Human    61 RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSY---FL-----YSRDGHSPGTL 117

  Fly   702 ELNVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEE---------DRVEFKNVT 757
            .:.|.:...|:.:.|     .|:|....|.....:.....:||.:.:         ||..:..:.
Human   118 GVYVRVNGGPLGSAV-----WNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLD 177

  Fly   758 QLEDLSSPSVRIP-----------------IEDLSPGR---QYRFEVQASSNGI--RSGTTHLST 800
            .:..||.|..:.|                 .:.::.||   ..||.:|..|..:  .:|..|:|.
Human   178 DILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISH 242

  Fly   801 R----TMPL-----IQSDVF--IANAGHEQGQDE--TITLSYTPTP--------ADSTRFDIY-- 842
            |    |.||     .:.|::  ::.|....|...  .:.:...|||        |..|...|.
Human   243 RRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLN 307

  Fly   843 -RFSMGDPTIKDKE------------------------KLANDTERKLSFSGLTPGKLYNVTVWT 882
             ...:||..|..||                        .|..|||.::|.....||
Human   308 TNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPG--------- 363

  Fly   883 VSGGVASLPVQRLYRLHPLPISDLKA------------IQVAAREITLHWTAPAG-------EYT 928
             .||..        |..|..||..|.            .::.||::||.| .|.|       .||
Human   364 -DGGTG--------RPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQW-EPLGYNVTRCHTYT 418

  Fly   929 DFELQYLSADEEAPQLLQNVTKN----TEITLQGLRPYHNYTFTVVVRS--GSIQGTDFADVSVS 987
            .....:.:......|.::...|.    :..|::.|.||.|....:|:.:  |..:|.:
Human   419 VSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKE------- 476

  Fly   988 TLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTF---------EWSLEPAEQHGPIDYFRI 1043
                      .::||        |...||.:....:||         :|. ||.|.:|.|..:.|
Human   477 ----------VTFQT--------DEDVPSGIAAESLTFTPLEDMIFLKWE-EPQEPNGLITQYEI 522

  Fly  1044 TCQ---NADDAADVSSYEFPV----NATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPI 1101
            :.|   ::|.|.:|......:    |.|......|.||..|:|.::|::..|:|.......|..|
Human   523 SYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNI 587

  Fly  1102 LAP-----PVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPS 1161
            .||     .:|.|      :..:.:||.:..|......|  .:..|.:|:.|:..:...  ..|.
Human   588 SAPSFDYADMPSP------LGESENTITVLLRPAQGRGA--PISVYQVIVEEERARRLR--REPG 642

  Fly  1162 WQDVQAYTVWLPYQA------IEPYNPFLTSNGSRKSSL-EAEHFTIGTANCDKHQAGYCNGPLR 1219
            .||  .:.|.|.::|      :..:...|.:     ||| ||..||:|.   ::...|:.|.||.
Human   643 GQD--CFPVPLTFEAALARGLVHYFGAELAA-----SSLPEAMPFTVGD---NQTYRGFWNPPLE 697

  Fly  1220 AGTTY-------------------RIKIRAFTDEDKFTDTVYSSPI-TTERSDTVIVAATVSA-- 1262
            ....|                   ||..:|...|.|       .|: .::||:.:.:...:.|
Human   698 PRKAYLIYFQAASHLKGETRLNCIRIARKAACKESK-------RPLEVSQRSEEMGLILGICAGG 755

  Fly  1263 ----VLLVAMVLVVV------------------------YCQHRCQLIRRASK-----LARMQDE 1294
                :||:..::|::                        |.|.:..::....:     ....:||
Human   756 LAVLILLLGAIIVIIRKGRDHYAYSYYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDE 820

  Fly  1295 LAAL----PEGYIT-------------------PNRP----------------VHVKDFSEHYRI 1320
            ...|    ..||.|                   |.||                |.|.|..:|...
Human   821 RLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQ 885

  Fly  1321 MSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNI----LP-YDHSRFKLQPVDDDDG 1380
            |.....:.|.:|:|..          |......:.|::....    :| ||..|.||.|:..|..
Human   886 MKTAEGYGFKQEYESF----------FEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPN 940

  Fly  1381 SDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVD 1445
            :|||||||:.|::....||.||||......:||||.|:.:..:|||:|:..|.||.||.:|||.|
Human   941 ADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPED 1005

  Fly  1446 RVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCES--RIMRHFHFTTWPDFGVPEPPQSLVRFVR 1508
              :..|||||:.|:......::.:..|.:.|...|  ..:|.||||.||:.|||.....|:.|:|
Human  1006 --SDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIR 1068

  Fly  1509 AFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQ 1573
            ..:.....|..||::|||||.||:|.:|.||.:|........|||:..|..:...||.|:|||:|
Human  1069 RVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQ 1133

  Fly  1574 YVCIHQCLLAVLEGKEHLLADSLELHANDGYEVTKIYLERQPQTKMGTL--------PIRASLAM 1630
            |:.||..:|      |..|.....:..::.....|..:...||:....|        .:...|.:
Human  1134 YIFIHDAIL------EACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDV 1192

  Fly  1631 AEKLDADLMTNKDEDEDQE 1649
            .|...|.|..|:|::...:
Human  1193 EECSIALLPRNRDKNRSMD 1211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	23/120 (19%)
		fn3	708..796	CDD:394996	20/118 (17%)
		fn3	902..978	CDD:394996	21/100 (21%)
		fn3	1013..1092	CDD:394996	25/94 (27%)
		PTP_tm	1127..1247	CDD:465889	31/146 (21%)
		R3-PTPc	1358..1579	CDD:350396	90/227 (40%)
PTPRU	NP_005695.3	MAM	22..186	CDD:214533	27/137 (20%)
		fn3	291..365	CDD:394996	15/83 (18%)
		FN3	<347..>624	CDD:442628	71/329 (22%)
		fn3	494..577	CDD:394996	22/83 (27%)
		Mediates interaction with CTNNB1. /evidence=ECO:0000250	771..887		15/115 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	833..861		4/27 (15%)
		R-PTPc-U-1	943..1147	CDD:350480	84/211 (40%)
		R-PTPc-U-2	1232..1438	CDD:350485