DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp4E and ptprh

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	XP_017209510.2	Gene:	ptprh / 100535694	ZFINID:	ZDB-GENE-091118-90	Length:	1068	Species:	Danio rerio

Alignment Length:	1190	Identity:	314/1190 - (26%)
Similarity:	494/1190 - (41%)	Gaps:	241/1190 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   451 LHISWEPAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRY---LIA 512
            |...|:.|  |..:||..........|::     :.|.   |.|...|.:..|.:|..|   |..
Zfish    37 LTFQWDKA--GGSNSYSYILRRDGIDSDI-----ITAG---TVNQVTYKVSDLSSGTNYNWTLFT 91

  Fly   513 VQALSKGVASNASDITRYTRPAAPLIQELRSIDQG---LMLSWRSDVNSRQDRYEVHYQRNGTRE 574
            |....:....|.|..|     ..|.::.:..|||.   :.|.|:.|        :..|..|.|..
Zfish    92 VFGDQRSEGKNFSAAT-----VPPNVESVSVIDQSETTITLQWKKD--------KAEYSYNLTYG 143

  Fly   575 ERTMATNETSLTIHY----LHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNL 635
            ::.........|:.|    |.||:.|...::.:..|::|...|:|....|...:::::.......
Zfish   144 DKVDTPPSPQSTVEYTVTSLSPGTNYSFTLYTVFEGLKSSGFSFFAVTVPPNVESVSVIDQSETT 208

  Fly   636 VVLHWQAPEGSDFS---EYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVES 697
            :.|.|: .:.:::|   .|..:.:|.:||...:      |..:..:..|.:|...:.||..|::|
Zfish   209 ITLQWK-KDKAEYSYNLTYEDKVQTPSSPQSPV------EYTVTSLSPGTKYTFTLYTVFEGLKS 266

  Fly   698 PHPLELNVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDL 762
            .......||:|.:.....|.......||.:|.:   ..|.||.:...:|...::.|.:.|
Zfish   267 SGFSFSAVTVPSKITGFSVIGRSETALTFQWTK---EKDEYTYELDKSDANTQISFTDTT----- 323

  Fly   763 SSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITL 827
                |...|..||||.:|.:.:.|...|::|....:|..|:|....:|.:..|     .|..:.|
Zfish   324 ----VVCLITSLSPGTEYSYNLYAVFEGVKSQAKGISEVTVPSNVENVSVVEA-----NDTDVIL 379

  Fly   828 SYTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTV-----SGGV 887
            .:...|.:..::: |.....|  :::......:.|.|...|||.|...||.|:.|.     |.|
Zfish   380 QWNAVPNEQNKYN-YILKYND--VEESVDFTTENEIKHHVSGLIPATNYNFTLHTEFYSQNSTG- 440

  Fly   888 ASLPVQRLYRL-HPLPISDLKAIQV--AAREITLHWTA----PAGEYTDFELQYLSADEEAPQLL 945
                    |.. |...:|.:..::|  :..|:|:.|..    ....||.........|.....::
Zfish   441 --------YNFNHTTFLSSVTEVRVNRSLTELTVEWNKLNQNNVYNYTLLRSDGAEIDFTGSAVV 497

  Fly   946 QNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKV 1010
            .:|.|:   ....|:|...|:||:              .:||..:|||   ..|::::||    :
Zfish   498 GDVIKH---KYSSLKPGTVYSFTL--------------FTVSNNVRSS---EHSFKSITA----L 538

  Fly  1011 DYFQPSDVQPGEVTFEWSLE----PAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGL 1071
            |.          .:|.|.:.    .|:.:| ..|  :|.||:..:...:|.|    ..:..:..|
Zfish   539 DC----------ASFNWKVTNTSIVADVYG-CTY--VTAQNSSGSGKNASIE----GDKVNLRDL 586

  Fly  1072 VPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAH 1136
            .||..|..      :|.|..|.:      :|.......::.|..||        :.:..|.|..:
Zfish   587 YPGESYTV------SLFYNLESK------MLTQCSQRLTLVPYVVS--------NLKCEYHSGGY 631

  Fly  1137 GMVRSYTI------IIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLE 1195
            |:...:..      ::..||.|.:                            |..|:||.:.:
Zfish   632 GLAVMWDYPDGVVDVVEVDVNKKS----------------------------FNHSHGSDEPT-- 666

  Fly  1196 AEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIV---- 1256
             :....|               |:|...|::|..:|:.              ..||:|:::
Zfish   667 -QQLVTG---------------LQAAQWYKVKATSFSG--------------ARRSETILINCQT 701

  Fly  1257 -AATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQD---ELAALPEGYITPNRPVHVKDFSEH 1317
             .|.|.|.:||..:||::.|.......|..|......|   :|....:.|.|    :....|.||
Zfish   702 DPAGVIAGVLVFFLLVIIICAGVFVWFRYKSARNNGPDASADLKVSKKNYKT----IACDKFPEH 762

  Fly  1318 YRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSD 1382
            :|.||.|.:..||.|:::|..||.:|:...|.||.|:.||||:|:||||.||..| .::....||
Zfish   763 FRNMSRDDNRAFSAEYDDLSSVGVEQSKVAALLPENKDKNRFSNVLPYDTSRVHL-TINKAGDSD 826

  Fly  1383 YINANYMPGH-NSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDR 1446
            |||||||||: |:.||:|..||||.||..:||||.||..|..|||:|.|.|.||.||:||||:|.
Zfish   827 YINANYMPGYGNASREYIAAQGPLPSTVNDFWRMIWEKKSSTIVMVTNCTEGGRVKCEQYWPLDY 891

  Fly  1447 VAMFYGDIKVQLIIDTHYHDWSISEFMVSR--NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRA 1509
            ....|.::.|.:..:.....|::.||.|..  ..|:|.:||||||.|||.|||...:.|::
Zfish   892 TPCLYENLLVTVKSENKSQSWTLREFNVKNKMTSETRTVRHFHFTAWPDHGVPRGTEELIQ---- 952

  Fly  1510 FRDVIGTDMR------PIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMV 1568
            |||:|...:.      |.:|||||||||:||.||||.:||.:::...|.:...|..||..|..||
Zfish   953 FRDLIRQHIESHFSTGPTVVHCSAGVGRTGTLIALDVLLQQLNREKAVGVAAFVQEMRLNRPLMV 1017

  Fly  1569 QTEQQYVCIHQCLLAVLEGK 1588
            |||.|||.:|||:|..|:.|
Zfish  1018 QTESQYVFLHQCILDSLQTK 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020
		fn3	247..328	CDD:278470
		fn3	343..417	CDD:278470
		fn3	443..525	CDD:278470	17/76 (22%)
		FN3	548..611	CDD:238020	14/66 (21%)
		FN3	620..706	CDD:238020	15/88 (17%)
		fn3	708..796	CDD:278470	21/87 (24%)
		fn3	824..886	CDD:278470	15/66 (23%)
		fn3	902..978	CDD:278470	15/81 (19%)
		fn3	1013..1092	CDD:278470	16/82 (20%)
		UP_III_II	1106..>1248	CDD:297589	19/147 (13%)
		PTPc	1329..1582	CDD:214550	125/261 (48%)
		PTPc	1355..1582	CDD:238006	114/235 (49%)
ptprh	XP_017209510.2	FN3	26..98	CDD:214495	16/70 (23%)
		FN3	109..182	CDD:238020	17/80 (21%)
		FN3	<156..352	CDD:225936	47/214 (22%)
		FN3	193..260	CDD:214495	11/73 (15%)
		FN3	361..>429	CDD:238020	16/75 (21%)
		RPA_2b-aaRSs_OBF_like	455..533	CDD:324543	20/97 (21%)
		PTPc	800..1032	CDD:238006	114/236 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920