Protein Alignment Ptp4E and col12a1

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_002936246.3
• Gene: col12a1 / 100495209
• XenbaseID: XB-GENE-1012295
• Length: 3121
• Species: Xenopus tropicalis
• Alignment Length: 1973
• Identity: 369/1973 - (18%)
• Similarity: 583/1973 - (29%)
• Gaps: 769/1973 - (38%)

  Fly    19 QIQIQTHGRKRQQLQKQRHNHHHYYQNSQQQQKHFVWLVVGILTI----------FLAQHANAAD 73
            |:.|||.|  |..|::.:.......:.|.......|:||.|..::          |:....:|.|
 Frog   109 QLTIQTGG--RVTLEEPKLETSKSPRCSISSVADVVFLVDGSWSVGRNNFKYILDFMVSLVSAFD 171

  Fly    74 L-----VINVPNASS------NANAFYR-----------------------IDY----------S 94
            :     .:.|...||      |.|::|:                       :||          .
 Frog   172 IGEDKTRVGVVQYSSDTRTEFNLNSYYKKEELVSAIKRIPYKGGNTMTGDALDYLIKNSFVKTAG 236

  Fly    95 PPFGFP-----------EPNTTIPASDI----------------GKDIKFSRALPGTEYNF---- 128
            ...|||           :....|||.::                .|::|...:||..::.|
 Frog   237 SRKGFPRIAIIITDGKSQDEVEIPARELRSLGVEVFSLGIKAADAKELKQIASLPSLKHVFNVAN 301

  Fly   129 ----------WLYYTNSTHREQLTWTVNITTAPDPPANLSVQLRSSKSAFITWRPPGSGRYSGFR 183
                      .:....|...|||:..|:...|.:||::::|...||||..|||||..| :.:|:|
 Frog   302 FDSIVEVQDEIITQVCSGVEEQLSELVSGEEAVEPPSDMTVTEISSKSMKITWRPSPS-QITGYR 365

  Fly   184 IRVLGLTDLPFERSYSLE-GNETLQLSAKELTPGGSYQVQAYSV--YQGKESVAYTSRNFTTKPN 245
            |::|.:  |...:.:||. |.:|..::.|:|:|...||:..|::  ....|.::...:....|..
 Frog   366 IQLLPM--LAGSKQHSLNLGPQTTSINVKDLSPDTEYQINLYAMKGLTASEPISTLEKTQAVKIK 428

  Fly   246 TPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRV-----------SITPD---------------- 283
            ......|..:.:..|||  ...:..|:....:|           .|:|.
 Frog   429 VECSGGVDIKADVVLLV--DGSYSIGVANFAKVRAFLEVLVKSFDISPSKVQISLVQYSRDPFTE 491

  Fly   284 ------DAIQSVL--------------------------YVEREGEPP-----------GPAQAA 305
                  |:|:.:|                          :||.:|..|           |.:..|
 Frog   492 FTLNRYDSIEDILKAVNTFPYRGGSTNTGKAMTYVREKVFVEIKGARPNVPRVMILITDGKSSDA 556

  Fly   306 FKG-LVPGREYNISVQTV-------SEDETSSVPTTARYL------------------------- 337
            ||. .:..|..::.:..|       ||.|..:.|.:..::
 Frog   557 FKDPAIKLRNSDVEIFAVGVKDAVRSELEAIASPPSDTHVYTVEDFDAFQRISFELTQSICLRIE 621

  Fly   338 ----TVPERVLNVTFDEAYT--TSSSFRVRWEPPR--TYSEFDAYQVMLSTSRR-IFNVPRAANG 393
                |:..:.|....|.|::  ||:||||.|.|..  ..|....|:|.:..... |.:|| |...
 Frog   622 QELQTIKRKSLTPARDLAFSEVTSNSFRVNWSPAAEDVLSYLVKYKVAVGEGEEFIVSVP-APKT 685

  Fly   394 DSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASG-----EVTLRPRPVRSLGGFLDDRSNALHI 453
            .:|..:    |.|..||.|.|....:...|.|.:|     |||..||.:|    ..|:.:::..:
 Frog   686 TTVLSN----LLPETTYAVAVLAEYEEGESPPLNGEETTLEVTGPPRNLR----VSDETTDSFKV 742

  Fly   454 SWEPAETGRQDSYRISYHEQTNASEVPAPFPVA--AESQITTNLTEYTLDSLLAGRRYLIAVQAL 516
            .|.|| .|....|||:|.            |||  |..::|           :.||..:..:|.|
 Frog   743 GWSPA-PGNVLRYRIAYR------------PVAGGARREVT-----------VPGRETVTTLQNL 783

  Fly   517 SKGVASNASDITRY-TRPAAPLI------------QELRSID---QGLMLSWRSDVNSRQDRYEV 565
            :.......|.|..| :.|..||.            :.||..|   ..|.|||.| ...:..:|.|
 Frog   784 TPDTKYQVSVIPEYHSGPGKPLTGNGATEEVLGEPRNLRVSDATTSSLKLSWDS-APGKVLQYLV 847

  Fly   566 HY--QRNGTREERTMATNETSLTIHYLHPGSGYEVKVHAI----------SHGVRSEPHSYFQAV 618
            .|  ...|..:|.|:..|.||..:..|.|.:.|.:.|.|:          ..|...:...
 Frog   848 TYNPSAEGETKEVTVRGNTTSTVLKGLDPSTTYSLSVAALYRSGAGSLLTGEGTTLDERG----- 907

  Fly   619 FPKPPQNLTLQTVHTNLVVLHWQAPEG--------------SDFSEYVV---------------- 653
               .|:||..:.:....:...|.|..|              .|..|..|
 Frog   908 ---SPRNLVTKDITDTTIGASWTAAPGMVRGYRIAWKSLFDDDSGEKNVPGGITNTVLENLRPET 969

  Fly   654 --------RYR------------TDASP------------------WQRISGLHENEARIKDMHY 680
                    .||            |:|||                  ||...|...|...|.....
 Frog   970 KYKISVFANYRSGEGDPLEGEATTEASPSAKLLKVSDETETTMKVTWQPAPGNVANYRVIYRPKL 1034

  Fly   681 GERYLVQ------------------------VNTVSFGVESPHPLELNVTMPPQPVSNVV---PL 718
            |.|.:|.                        |.....|...|...|.....|.:|..|:.   |.
 Frog  1035 GGRQVVAKVPATVSSTVLKRLQPQTTYDITVVPVYKAGDGKPRQGEGTTASPFKPPRNLKTSDPT 1099

  Fly   719 VDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRV------EFKNVTQLEDL--------------- 762
            :.:..:|.| |.| |.|..|.:.::|..||..:      .:.|...||:|
 Frog  1100 ISTFRVTWE-PAP-GEVRGYKITYFPFGEEQYLGELVVGPYDNTVVLEELRAGTSYKVNVFGVFE 1162

  Fly   763 ----------------SSPSVRIPIEDL------------------SPGR--------------- 778
                            .:|.|||....|                  |.||
 Frog  1163 KGESVPLIGQEMTTLSDAPEVRIDSSGLECKTKAAADIVLLVDGSWSIGRPNFRTVRSFIARLVE 1227

  Fly   779 --------------QY----RFEVQASSNGIR------------SGTTHLSTRTMPLIQSDVFIA 813
                          ||    |.|.|.:::..:            .|...|:...:..|..:.|.|
 Frog  1228 VFDIGSDRVQIALAQYSGDPRSEWQLNAHSTKKSLMDAVANLPYKGGNTLTGMALNFILQNNFKA 1292

  Fly   814 NAG----------------------------HEQG----------------------QDETITLS 828
            .||                            .:||                      .|||...:
 Frog  1293 EAGMRAKSKKIGVLITDGKSQDDIVAPSKKLRDQGIDLFAIGIKNADENELRQIGSDPDETYVFN 1357

  Fly   829 YT-------------------------------------PTP-------------ADSTRFDIYR 843
            ..                                     |||             .|..|.:.|.
 Frog  1358 VADFSLLVNIVDDLTTNLCNSVKGSGNELEPPSDLVTSEPTPRSFRVTWNPPSHSVDRFRVEYYP 1422

  Fly   844 FSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQRLYRLHPLP-ISDLK 907
            .|.|.|.    |.....::|....:.|.|...|.|.|::|..|.:|.|::......|:| :.:|.
 Frog  1423 VSGGRPL----EVFVGRSDRTTVLTNLKPETEYVVKVYSVLEGESSEPLEGTETTLPIPSVRNLN 1483

  Fly   908 AIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQL---LQNVTKNTEITLQGLRPYHNYTFTV 969
            ...:..|.:.:.|.|..|. |.:.|||...:...|..   |:.....|::.|:.|.|...||.||
 Frog  1484 IYDIGTRTMRVRWEAALGA-TGYLLQYEPVNATVPSTEKELRVGASVTDVLLEDLFPNTEYTLTV 1547

  Fly   970 VVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQ 1034
            ......:               .|.|:::  |.:|.|...|...:..|:....:...||..|.
 Frog  1548 YALFDEL---------------ISDPLTS--QEVTLPIQGVGNIRVRDITHSSMNVLWSAAPG-- 1593

  Fly  1035 HGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTM 1099
             ..:.|  |.....::..:....|...:.|..::..|.....|...:.|....|....|    |.
 Frog  1594 -NVLKY--IVRYKTEEEEEFKEVEVDGSRTSTRLTDLFSQTLYEISLTAVYDEGVSQPR----TT 1651

  Fly  1100 PILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQD 1164
            .....|||.|:  .|..|..:.|   |||..:   .||.                        .|
 Frog  1652 QGTTAPVPAPA--NLRFSEIAVT---SFRGTW---EHGA------------------------PD 1684

  Fly  1165 VQAYTV-WLPYQAIEPYNPFLTSNGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKI 1228
            |..|.: |.|..|||.         .:::.::.:   |.|...|:         |...|.|.:.:
 Frog  1685 VALYRITWAPVGAIEK---------KKETIVDGD---INTLVFDE---------LEPDTEYEVSV 1728

  Fly  1229 RA-FTDEDKFTDTVYSSPITTERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIR--RASKLAR 1290
            .| :.||.:..|.     |..||:...|: :|..|:......|.|.........:|  ||
 Frog  1729 TAIYPDESESEDL-----IGVERTLPEII-STTPALRTGPRNLQVFNATQNSLTVRWDRA----- 1782

  Fly  1291 MQDELAALPEGYITPNRPVHVKDFSEHYRIMSADSDFRFSEEFEEL------------------- 1336
            |.|                 |:.::.:|:.:||..    :|:...:
 Frog  1783 MGD-----------------VQKYNIYYKPVSAAG----AEQMTSVGGKQNSVVLQRLQPDTPYN 1826

  Fly  1337 -----KHVGRDQACSFANLPCNRPKNRFTNILPYDHS----------------RFKLQPVDDDDG 1380
                 :::|.::..:.:.....:|.|...|:..||.:                |:|:.
 Frog  1827 IVVSSRYIGDEEGGNISGRGKTKPLNTVKNLRVYDPTTSTLNVRWEAAEGNVRRYKIY------- 1884

  Fly  1381 SDYINANYMPGHNSPREFIVTQG 1403
                   |:|....|.|.:...|
 Frog  1885 -------YVPTAGGPEETVTVPG 1900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	72/361 (20%)
		fn3	247..328	CDD:394996	24/158 (15%)
		FN3	319..>749	CDD:442628	127/600 (21%)
		fn3	708..796	CDD:394996	32/190 (17%)
		fn3	902..978	CDD:394996	20/79 (25%)
		fn3	1013..1092	CDD:394996	12/78 (15%)
		PTP_tm	1127..1247	CDD:465889	22/121 (18%)
		R3-PTPc	1358..1579	CDD:350396	10/62 (16%)
col12a1	XP_002936246.3	fn3	26..97	CDD:394996
		vWA_collagen_alphaI-XII-like	139..302	CDD:238759	26/162 (16%)
		fn3	336..415	CDD:394996	28/81 (35%)
		vWA_collagen_alphaI-XII-like	439..602	CDD:238759	24/164 (15%)
		FN3	<624..1069	CDD:442628	106/486 (22%)
		FN3	1089..1176	CDD:238020	17/88 (19%)
		vWA_collagen_alphaI-XII-like	1198..1361	CDD:238759	20/162 (12%)
		FN3	1387..1473	CDD:238020	20/89 (22%)
		FN3	1477..1549	CDD:214495	20/72 (28%)
		FN3	1571..1648	CDD:238020	13/81 (16%)
		FN3	1616..>1993	CDD:442628	68/388 (18%)
		fn3	2035..2112	CDD:394996
		FN3	2125..2204	CDD:238020
		fn3	2214..2283	CDD:394996
		vWA_collagen_alphaI-XII-like	2329..2493	CDD:238759
		TSPN	2527..2718	CDD:214560
		gly_rich_SclB	<2769..3087	CDD:468478