Protein Alignment Ptp4E and tnn

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_017949080.2
• Gene: tnn / 100491528
• XenbaseID: XB-GENE-998034
• Length: 1109
• Species: Xenopus tropicalis
• Alignment Length: 656
• Identity: 137/656 - (20%)
• Similarity: 226/656 - (34%)
• Gaps: 165/656 - (25%)

  Fly   354 TSSSFRVRWEPPRTYSEFDAY--------------QVMLSTSRRIFNVPRAANGDSVYFDYPDIL 404
            |..|..:.|:   ...|.|.|              ::.:|..:..:.:..              |
 Frog   458 TEDSLSIAWD---MLLEVDYYLLVYYPLDNEGLKKEIQVSVDKDTYQIMG--------------L 505

  Fly   405 EPGRTYEVVVKTIADNVNSWPASGEVTLRPRPVRSLGGF--LDDRSNALHISWEPAETGRQDSYR 467
            .||..|:|::....:.|.|.||  |:..:...: |||..  .::..::|.:.||.... ..|.|:
 Frog   506 NPGTKYKVLMYNAKNGVTSQPA--ELLAKTDSI-SLGTLWVAEETEDSLEVEWENPIV-NVDHYK 566

  Fly   468 ISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKGV---ASNASDITR 529
            :.|.:|.|.:|...   :.::||  ...:.||:..|.....|.|:||.:..|:   .|.|..:|.
 Frog   567 LKYAQQLNGAEREV---IVSQSQ--DPKSRYTITGLQPSTSYQISVQTVRSGLEGKPSTAVGVTG 626

  Fly   530 YTRPAAPLIQELRSIDQGLMLSWR---SDVNSRQDRYEVHYQRNGTREERTMATNETSLTIHYLH 591
            ...|...:..|:.  :....|||:   :|::....||..|   :|..||.::...:.|.::..|.
 Frog   627 IDGPKNLVTTEVG--EDTASLSWKGSQADIDKYMLRYSAH---DGIAEEISLGKEKISTSLSNLT 686

  Fly   592 PGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAP-----------EG 645
            ||:.|...:.|.....:|:..|........||:||........ ..|.|..|           |.
 Frog   687 PGTEYMFHLWAEKGTQQSKRTSVTAVTEIDPPKNLQYSKSQPQ-ASLTWNQPIAQIDGYVLVLED 750

  Fly   646 SDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLV------------QVNTVSFGVESP 698
            ||..:..::..:..           |...::|::.|.:|.|            || |.||..:..
 Frog   751 SDGGQQEIQLDSTV-----------NNFELQDLNKGLKYTVYLLAYRGDRRSRQV-TTSFYTDID 803

  Fly   699 HPLEL---NVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLE 760
            .|..|   :||              ....:|.|..|...:|.|.|.:...|        ..|:..
 Frog   804 PPTNLQSFDVT--------------QTEASLTWTPPRAKIDGYILTYTDAD--------GSTEEI 846

  Fly   761 DLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLI----------------QSD 809
            .|.|.|....:::|..|.:|...:.|.....||........|:..|                ||.
 Frog   847 QLDSSSKSFAMKNLKKGLKYTVYLTAFKGDSRSSQASTIFSTVAFIITHPSDCIQIQLSGNRQSG 911

  Fly   810 VFIANAGHEQGQDETITLSYTPTPAD-----------STRFDIYR------FSMGDPTIKDKEKL 857
            |:....|.:..:...:   |.....|           |.:.|.|:      ...|||:  |:..|
 Frog   912 VYTIYPGGDTAKGVRV---YCDQETDGGGWIVFQRRNSGKLDFYQRWRTYVEGFGDPS--DEFWL 971

  Fly   858 ANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQRLYRL------HPLPISDLKAIQVAAREI 916
            ..:...||:.|   ||..|.:.|...:|..:.....|.:|:      :.|.|||...  .|...:
 Frog   972 GLEWIHKLTSS---PGNNYEIRVDLRAGDESVYAFYRNFRVGSSKDRYKLSISDYSG--TAGDGL 1031

  Fly   917 TLH--W 920
            |.|  |
 Frog  1032 TYHNGW 1037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	93/442 (21%)
		fn3	708..796	CDD:394996	17/87 (20%)
		fn3	902..978	CDD:394996	7/21 (33%)
		fn3	1013..1092	CDD:394996
		PTP_tm	1127..1247	CDD:465889
		R3-PTPc	1358..1579	CDD:350396
tnn	XP_017949080.2	EGF_CA	161..194	CDD:238011
		EGF_Tenascin	355..382	CDD:480934
		fn3	449..513	CDD:394996	11/71 (15%)
		fn3	543..619	CDD:394996	19/81 (23%)
		FN3	599..1043	CDD:442628	103/489 (21%)
		FReD	895..1105	CDD:238040	32/153 (21%)