DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp4E and ptprbl

DIOPT Version :9

Sequence 1:NP_001162669.1 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster
Sequence 2:XP_021326526.1 Gene:ptprbl / 100333658 ZFINID:ZDB-GENE-130522-4 Length:931 Species:Danio rerio


Alignment Length:1081 Identity:254/1081 - (23%)
Similarity:414/1081 - (38%) Gaps:229/1081 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   260 LLVLWQPPFPAGIYTHYRVSITPDDAIQSVLYVEREGEPPGPAQAAFKGLVPGREYNISVQTVSE 324
            |.|.|:.  ..|....|.||:...:.....|.|.:..     .:..||.||.||.||||:.:.|.
Zfish    26 LSVSWRA--AEGDVDSYWVSLRDRERTVHTLTVSKVS-----TECVFKSLVSGRLYNISITSRSG 83

  Fly   325 DETSSVPTTARYLTVPERVLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRIFN--- 386
            :..:.  |..:..|.|..|||.|... .......:|.|.  ....:||.|.|.:. ...||:   
Zfish    84 EFE
NH--TAVQERTQPSPVLNPTATH-MAEEQLLKVYWR--HAEGDFDYYHVSIK-HNNIFHQNR 142

  Fly   387 -VPRAANGDSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLRPRPVRSLGGFLDDRSNA 450
             ||::.| :.|:..    |.|||.|.|.|.|.:....|..::...|| |..|::| ...|..:..
Zfish   143 TVPKSQN-EYVFSG----LVPGRLYMVTVSTWSGKYES
SVSTHGSTL-PARVQNL-SLADSGTED 200

  Fly   451 LHISWEPAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQA 515
            |.::|..| .|..|.|.:..  ..|..:|..|.      .:|::.|:|.|.||..||.|.|.|..
Zfish   201 LLVTWASA-PGDVDHYEVQL--LFNDMKVFPPI------TLTSSTTQYLLSSLTPGRLYKILVST 256

  Fly   516 LSKGVASNASDITRYTRPAAPLIQELRSIDQG----LMLSW---RSDVNSRQDRYEVHYQRNGTR 573
            .| |.......:...|.|:.  ::.:...::|    |.:||   :.||    |||.|.....   
Zfish   257 FS-G
PNLRVQFLRGRTVPST--VKNIHISNEGQSSSLRVSWTPGQGDV----DRYTVSLSPG--- 311

  Fly   574 EERTMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVL 638
            :||.:..:...::..:|.||..|.:.|.:||                                  
Zfish   312 QERFVPKHVNEVSFQHLQPGQQYNITVTSIS---------------------------------- 342

  Fly   639 HWQAPEGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLEL 703
                  ||..:......||..||   :|.|...|.|                             
Zfish   343 ------GSLINNSTATGRTVPSP---VSALQLEEQR----------------------------- 369

  Fly   704 NVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVR 768
                            .:..|::.|....|..|.:.|:.  .||...: ..|::    .::.:::
Zfish   370 ----------------STSTLSVFWQAGQGVFDSFRLQL--LDERGTL-VSNIS----TAAQAIQ 411

  Fly   769 IPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSY--TP 831
            .....|:||:.||..::|.|.|:.|....:..||.|...||:.:.:       :.|.:||:  .|
Zfish   412 HTFTHLTPGKPYRVLIRALSGG
VSSNDVEVEGRTCPATVSDLSVIS-------NTTTSLSFRWAP 469

  Fly   832 TPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQRLY 896
            ...:...||:..:...:..:..|..:..|    .||..|.||.||.|.::|.||...: ......
Zfish   470 PVGEFDGFDVLLYDEDERLLDQKSGVMQD----CSFLNLRPGLLYKVLIFTRSGDQTN-STSIWA 529

  Fly   897 RLHPLPISDLKA-IQVAAREITLHWTAPAGEYTDFELQYLSAD--EEAPQLLQNVTKNTEITLQG 958
            |..|..::.|.| .:.::..:.|.|..|||..:.:.|..|:.|  ..|.|.|...:::.:  .|.
Zfish   530 RTVPAAVTFLHADSRRSSESLWLSWKQPAGAVSSYTLLILNPDGTRTAEQSLGPDSRSHQ--FQS 592

  Fly   959 LRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEV 1023
            |.....|...|:..||.:  |:.|..|..|  ....|:|.|:..:|....::.:..|.:....:.
Zfish   593 LVSGRLYQAVVLTHSGDL--TNMATTSDRT--DPKPPVSFSFGEITNTSLEITWSAPENTDYDDF 653

  Fly  1024 TFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSALG 1088
            ..:||        |.|:..:          .:.|..|.:|.: .:.|:.||..|...::..|   
Zfish   654 DLQWS--------PRDHLSV----------FNPYHSPTSANR-ILKGMHPGRQYNISLRTVS--- 696

  Fly  1089 YGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKN 1153
             ||...:.:.:.|..||:|...:....|:.|.|||...|...:||:.:|.|:.:||:|.|   .:
Zfish   697 -GAGTNNPRVLVISGPPLPMARIDENAVTITKSTILFQFNCSWFSDINGAVKFFTIVIIE---SD 757

  Fly  1154 ASGLEMPSWQDVQAYTVWLPYQ---AIEPYNPFLTSNGSRKSSLEAEHFTIGTAN--------CD 1207
            .|..:.|  |.|.....:|.|:   :|:.|......:...:|...|:.|.:...:        ||
Zfish   758 DSERQQP--QQVHPLPSYLDYRSNSSIKAYQTSFFRSHCDESQSPAQEFRVQLGSGMESLGGRCD 820

  Fly  1208 --------KHQAGYCNGPLRAGTTYRIKIRAFT---DEDK-------FTDTVYSSPITT--ERSD 1252
                    :.|..:|:|||:..|.||:.:||||   |||:       :|||..|.|:.|  |...
Zfish   821 QKTSTGGSQEQTAFCDGPLKPRTAYRLSVRAFTKLYDEDREEFLSPLYTDTYLSKPLLTHAEPLS 885

  Fly  1253 TVIVAATVSAVLLVAMV--LVVVYCQHRCQLIRRASKLARM 1291
            .||...:....|:..||  :|::.|:.:...:.....:.||
Zfish   886 GVIEGVSAGLFLIATMVGLIVLLVCRQKVHKMSAQEPVVRM 926

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp4ENP_001162669.1 FN3 151..242 CDD:238020
fn3 247..328 CDD:278470 20/67 (30%)
fn3 343..417 CDD:278470 23/77 (30%)
fn3 443..525 CDD:278470 23/81 (28%)
FN3 548..611 CDD:238020 18/65 (28%)
FN3 620..706 CDD:238020 10/85 (12%)
fn3 708..796 CDD:278470 17/87 (20%)
fn3 824..886 CDD:278470 18/63 (29%)
fn3 902..978 CDD:278470 19/78 (24%)
fn3 1013..1092 CDD:278470 14/78 (18%)
UP_III_II 1106..>1248 CDD:297589 48/170 (28%)
PTPc 1329..1582 CDD:214550
PTPc 1355..1582 CDD:238006
ptprblXP_021326526.1 fn3 11..86 CDD:306538 20/66 (30%)
fn3 98..175 CDD:306538 24/85 (28%)
fn3 188..259 CDD:306538 24/81 (30%)
fn3 274..343 CDD:306538 19/117 (16%)
fn3 358..433 CDD:306538 21/129 (16%)
FN3 450..520 CDD:328772 20/80 (25%)
fn3 624..699 CDD:306538 18/97 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D16347at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.010

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