Protein Alignment Ptp4E and ephb1

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_017207747.1
• Gene: ephb1 / 100333537
• ZFINID: ZDB-GENE-070912-219
• Length: 1011
• Species: Danio rerio
• Alignment Length: 825
• Identity: 144/825 - (17%)
• Similarity: 241/825 - (29%)
• Gaps: 310/825 - (37%)

  Fly   877 NVTVWTVSGGVASLPVQRLYRLHPLPISDLKAI-------------------QVAAREITLHWTA 922
            |...|.::..:|....||:|......:.|..:|                   .|.|.:.|..|.
Zfish    71 NQNNWLLTTFIARRGAQRIYVEMRFTVRDCSSIPRVPGSCKETFNLYYYETDSVIATKGTAFWM- 134

  Fly   923 PAGEYTDFELQYLSADEEAPQL-----LQNVTKNTEI----------------------TLQGLR 960
               |....::..::|||...|:     |..|  |||:                      :|..:|
Zfish   135 ---EAPYLKVDTIAADESFSQVDFGGRLMKV--NTEVRSFGPLSKNGFYLAFQDYGACMSLLSVR 194

  Fly   961 PYH--------NY------------TFTVVVRSGSIQGTDFADVSVSTLMR---------SSAPI 996
            .::        |:            |..|:.|...|..::..||.:.....         .|...
Zfish   195 VFYKKCPSVVQNFAIFPETMTGAESTSLVIARGMCIPNSEEVDVPIKLYCNGDGDWMVPIGSCTC 259

  Fly   997 SASYQ------TLTAPPG-----------------------------------KVDYFQP----- 1015
            .|.::      ....|||                                   :.|..||
Zfish   260 KAGFEPDNGNICRACPPGTFKASQGPGLCSQCPANSRSTSEAATICVCRNGYYRADGEQPDMPCT 324

  Fly  1016 ----------SDVQPGEVTFEWSLEPAEQHGPIDYF-----------RITCQNADDAADVSSYEF 1059
                      |.|....||.||. .|.|..|..|..           |.:|.:.||..:....:.
Zfish   325 SVPSGPRNVISIVNETSVTLEWH-SPRETGGREDVTYNIVCKKCQADRRSCSHCDDNVEFQPRQL 388

  Fly  1060 PVNATQGKIDGLVPGNHYIFRIQAKSALG----YGAEREHIQTMPILAPPVPEPSVTPL--EVSR 1118
            .:..::..|..|:....|.|.|||.:.:.    |.|:...|.    :......||:.|:  :||.
Zfish   389 GLTESRVFISNLLAHTLYTFEIQAVNGVSNKSPYPAQHVSID----ITTNQAAPSIVPIMHQVSS 449

  Fly  1119 TSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPF 1183
            |..:|.:|:.|.  ...:|::..|.:...|......:..:|.|
Zfish   450 TMKSITLSWPQP--EQPNGIILDYELRYYEKELSEVNSTQMRS---------------------- 490

  Fly  1184 LTSNGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDE-----------DKF 1237
                            ...||..|         .||.||.|.:::||.|..           ...
Zfish   491 ----------------QTNTARVD---------GLRPGTMYVMQVRARTVAGFGKYSSKMCFQTL 530

  Fly  1238 TDTVYSSPITTERSDTVIVAATVSA--VLLVAMVLVVVYCQHRCQLIRRASKLARMQDELAALPE 1300
            ||..|.|.:   |....::|.:.:|  |.:|::|.:.:.|:.:    |..:|.|...|:|.....
Zfish   531 TDDDYKSEL---REQLPLIAGSAAAGVVFIVSLVAISIVCRRK----RAYNKEAVYSDKLQHYST 588

  Fly  1301 GYITPNRPVHVKDFSEHYRIMSADS------------DFRFSEEFEELKHVGRDQACSFANLPCN 1353
            |.....||    |.|..:..|...:            .|.:.:..|.::...::
Zfish   589 GRELTLRP----DLSNCHTPMGCPTLPGSPGMKIYIDPFTYEDPNEAVREFAKE----------- 638

  Fly  1354 RPKNRFTNILPYDHSRFKLQPV--DDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMC 1416
                       .|.|..|::.|  ..:.|..|.....:||   .||..|....|.:...|..|..
Zfish   639 -----------IDVSTVKIEEVIGAGEFGEVYKGRLKLPG---KRELYVAIKTLKAGYSEKQRRD 689

  Fly  1417 WES---------------------NSRAIVMLTRCFEKG------REKCDQYWPVDRVAMFYG-- 1452
            :.|                     .||.::::|...|.|      |:...|:..:..|.|..|
Zfish   690 FLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEFMENGALDSFLRQNDGQFTVIQLVGMLRGIA 754

  Fly  1453 -DIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGV 1496
             .:|....::..:.|.:....:|:.|...::         .|||:
Zfish   755 AGMKYLSEMNYVHRDLAARNILVNSNLVCKV---------SDFGL 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628
		fn3	708..796	CDD:394996
		fn3	902..978	CDD:394996	23/141 (16%)
		fn3	1013..1092	CDD:394996	24/108 (22%)
		PTP_tm	1127..1247	CDD:465889	21/130 (16%)
		R3-PTPc	1358..1579	CDD:350396	32/171 (19%)
ephb1	XP_017207747.1	EphR_LBD_B	24..199	CDD:198440	24/133 (18%)
		fn3	330..421	CDD:394996	21/91 (23%)
		fn3	437..522	CDD:394996	25/133 (19%)
		EphA2_TM	546..641	CDD:464211	19/124 (15%)
		PTKc_EphR_B	639..907	CDD:173638	32/164 (20%)
		SAM_EPH-B1	933..1000	CDD:188950