DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp4E and ptprb

DIOPT Version :9

Sequence 1:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster
Sequence 2:	NP_001303656.1	Gene:	ptprb / 100149130	ZFINID:	ZDB-GENE-101108-3	Length:	1892	Species:	Danio rerio

Alignment Length:	1766	Identity:	467/1766 - (26%)
Similarity:	723/1766 - (40%)	Gaps:	372/1766 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 ASSNANAFYRIDYSPPFGFPEPNTTIPASDIGKDIKFSRALPGTEYNFWLYYTNSTHREQLTWTV 145
            ||.:.:: |.:..:.| |.......:|..|  ..:.|....||..|...: .|.|......||
Zfish   225 ASGDVDS-YLVSLTTP-GSNSIEKVLPPDD--TYVVFENLSPGKGYQVSV-STRSGALSNKTW-- 282

  Fly   146 NITTAPDP--PANLSVQLRSSKSAF-ITWRPPGSGRYSGFRIRVLGLTDLPFERSYSLEGNETLQ 207
             ||...||  .::|.::..|.:.|. |:|.|| ||.:...|:.:...:::...::......|.|
Zfish   283 -ITGKADPGKVSDLVIENLSVRGALKISWTPP-SGEWEHIRVALSNGSEVLRNQTVGRTAKEIL- 344

  Fly   208 LSAKELTPGGSYQVQAYSV----------YQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLV 262
            ||...|.||..|:: |.||          |:|:..:...|           :..|...:||:|..
Zfish   345 LSGLNLLPGRVYRM-AVSVENGGLANTVIYEGEIGLPPVS-----------QLHVRHSDETSLSA 397

  Fly   263 LWQPPFPAGIYTHYRVSITPDDAI------QSVLYVEREGEPPGPAQAAFKGLVPGREYNISVQT 321
            ||         .|...|.:.|..|      .:...::.........:..|..|.|||.|:|:|.|
Zfish   398 LW---------AHAASSSSRDGYIIQLFQSNTSTVIQTRNLSRDMRECTFNVLTPGRLYDITVTT 453

  Fly   322 VSEDETSSVPTTARYLTVPERVLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRR-IF 385
            .::...||.....|  |.|.:|.::......:| .|....||.|  ..:.|.|.::|...:: :.
Zfish   454 TAKIIRSSATLQGR--TQPLKVNHLKLSNKGST-DSLNASWEKP--LGDLDFYHMLLLRDQQTVH 513

  Fly   386 NVPRAANGDSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLRPRPVRSLGGFLDDRSNA 450
            |:..:||..|....:   |.||..::::|.||:.:..|..|..|....|..|..: ...:...:.
Zfish   514 NITASANTTSRLLPF---LRPGALHKILVTTISGSQTSKLAEAECRTVPAAVSDI-TVTNSGPDF 574

  Fly   451 LHISWEPAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQA 515
            |::||:.|| |..|:|.:...:|.....      ..|.|:.|   ||....||::||.|.|:: |
Zfish   575 LNVSWKAAE-GDVDNYVVMLKDQEKIVH------TLATSKAT---TECVFRSLVSGRLYSISI-A 628

  Fly   516 LSKGVASNASDITRYTRPAAPLIQELRSI----DQGLMLSWRSDVNSRQDRYEVHYQRNGTR-EE 575
            ...|...|.:.:...|:|:.  :|...:|    |..|.|.| :..:...|.|.|..:.|||| :.
Zfish   629 THSGSYRNQTLLQERTKPST--VQNPTAIHSARDDFLKLYW-NHASGDYDYYVVTIEHNGTRLQS 690

  Fly   576 RTMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHW 640
            :.:...::......|.||..|.:.|...| |......|.:...||....||:|.......:.:.|
Zfish   691 QKLNRTQSDCAFSDLVPGRLYNLTVSTWS-GQHYSAVSIYGRTFPGAVGNLSLTERGGTFLRVSW 754

  Fly   641 -QAPEGSDFSEYVVRYR-TDASPWQRIS---GLHENEARIKDMHYGERYLVQVNTVSFGVESPHP 700
             .||...|..|..:.:. |..|....:|   |.|...|    :..|..|.:.::|.|...:....
Zfish   755 TSAPGDVDHYELQILFNDTQVSAAVNLSSAIGEHLFSA----LTPGRLYKIVLSTHSGSYQRAEI 815

  Fly   701 LELNVTMPPQPVS-NVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTD--EEDRVEFKNVTQLE-- 760
            || ..|:|.|..| ::.......:|.:.|...||.:|||::..:...  ::.|...|::||.|
Zfish   816 LE-GRTVPSQVQSVHLSAGTADGSLRVSWSSADGDLDFYSVSLFQETHLQDSRRVPKHITQAEFY 879

  Fly   761 -----------------------------------------DLSSPSVRIP-------------- 770
                                                     :||:.|:.:.
Zfish   880 NLIPGQLYSVTVQSVSGSQTNNSTTTGRTEPSTVTGLRADNELSTHSLLVSWNPAVGVHDGYRLW 944

  Fly   771 ----------------------IEDLSPGRQYRFEVQ-----ASSNGI----------------- 791
                                  .|:|:|||:|:..|:     |.|..:
Zfish   945 LLDDGGTNIHNASVPAASRHHLFENLTPGRRYQAHVRTLSGTAESKDVVAEGQTRPSAVSALHVC 1009

  Fly   792 ---------------------------RSGTTHLST----------------------------- 800
                                       |..|.|..|
Zfish  1010 SNTSSDLSFCWASAVGWVDGYELYLYDRDETLHYHTTLGSDALGWSFTLLQPGTHYKMTITSKSG 1074

  Fly   801 ----------RTMPLIQSDVFIANAGHEQGQDETITLSYTPTPADSTRFDIYRFSMGDPTIKDKE 855
                      .|.|....::.:.|    |||.:::.||:||.|...|.:.:        |:..:|
Zfish  1075 KLSNQSSVWAHTAPASVPELHVEN----QGQTDSLLLSWTPAPGGLTGYSV--------TVDGRE 1127

  Fly   856 KLANDTERKLSFSGLTPGKLYNVTV--WTVSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITL 918
            :.......::.|..|..|:||..||  |:.....::..|.|.....|..:|    :..:...:.:
Zfish  1128 QRVGPEVTQVVFHSLVAGRLYLATVQTWSEDLSNSTTAVGRTVPAAPSSVS----VSCSGGSVDM 1188

  Fly   919 HWTAP-AGEYTDFELQYLSADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFA 982
            .|..| .|:|.|||:.:...|    .|..:..:.|:..|:||.|...|..::...||
Zfish  1189 KWHVPDTGDYEDFEVTWFPQD----TLYISHLRPTQRILEGLHPGRLYNISLRTVSG-------- 1241

  Fly   983 DVSVSTLMRSSAPISAS---YQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRIT 1044
                    :..:|::.|   |.|:..||..........:....|:..|:    ..|...|.|.:.
Zfish  1242 --------KRHSPVTYSRPVYHTIRTPPLPAPSIHCFPLSSTSVSCSWT----PPHSDYDGFVVQ 1294

  Fly  1045 CQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEP 1109
            |........|.::....:....:.|.|.|..:|...:...|.....:..::.....|..||||..
Zfish  1295 CHRQGSGKAVYTHTLGNHTLSQQFDRLEPFKNYTIYVAVMSGDKQSSTVKNSVITMIDRPPVPPV 1359

  Fly  1110 SVTPLEVSR--TSSTIEISFRQGYFSNAHGMVRSYTIIIAE----DVGKNASGLEMPSWQDVQAY 1168
            :|...|.|.  |..||...|...:||:|:|.:|.:|||..|    |.|.......:||:.|
Zfish  1360 TVRVNEHSAVITHFTIRFKFNCSWFSDANGAIRYFTIIATESNDVDNGLPEQRHPLPSYLD---- 1420

  Fly  1169 TVWLPYQAIEPYNP-FLTSNGSRKSSLEAEHFTIGTANCDKHQAG--------------YCNGPL 1218
              :....:|:.|.. :..|..:..|..:.:.|.|......||..|              .|:|||
Zfish  1421 --YRQNHSIKAYQTGYFHSTCAEGSDGKVQVFEINLGAGMKHLGGACKLDPESIQHGSHLCDGPL 1483

  Fly  1219 RAGTTYRIKIRAFT---DEDK-------FTDTVYSSPITTERSD-TVIVAATVSAVLLVAMVL-- 1270
            |:.|:||:.:||||   ||:.       :|||..|.|:.|:.:. :.:.....:|:.|:.|||
Zfish  1484 RSRTSYRLSVRAFTQLFDEENREFPHPLYTDTYLSLPLLTQSAPRSGLTGGITAALFLITMVLAL 1548

  Fly  1271 --VVVYCQHRCQLIRRASKLARMQDEL------AALPEGY--ITPNRPVHVKDFSEHYRIMSADS 1325
              :::|       .:||.|:|..:..:      .|||...  :....||...:|..|...:.:||
Zfish  1549 TALLIY-------RKRAHKIAVQESPVMKMCKWKALPTSQMCLRIRSPVQAANFESHLAKLQSDS 1606

  Fly  1326 DFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMP 1390
            .:..|||||.||.|||.|..:.|.|..||.|||:.||||||.:|.:|..::||..||||||||:|
Zfish  1607 SYLLSEEFEGLKDVGRIQTQNAARLLGNRNKNRYNNILPYDSTRVRLSCLEDDPCSDYINANYIP 1671

  Fly  1391 GHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIK 1455
            |:|...|:|.|||||..|:::||||.||.|..::||:|:|.|:|..|||.|||.|...:.||||.
Zfish  1672 GNNFRWEYIATQGPLPGTKDDFWRMVWEQNVHSLVMVTQCVERGMVKCDHYWPTDSEPLCYGDIV 1736

  Fly  1456 VQLIIDTHYHDWSISEFMVSRNCES-----RIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIG 1515
            |||:.:..:.:|:|.:|.:|  |||     |::|.||:|.|||.|||:..|||::|||..||.|.
Zfish  1737 VQLLSEKVFPEWTIRDFKIS--CESQLRYPRMVRQFHYTIWPDHGVPDTTQSLIQFVRTVRDFIN 1799

  Fly  1516 TDMRP--IIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIH 1578
            ....|  .:|||||||||:||||.|||.||.:.::..|||:|.||.:|..|.:|||||.||..||
Zfish  1800 RTNSPGISVVHCSAGVGRTGTFIVLDRALQQLDRNCTVDIYGCVFDLRLHRSYMVQTECQYAYIH 1864

  Fly  1579 QCLLAVLEGKE 1589
            ||:..||..::
Zfish  1865 QCVRDVLRARK 1875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020	26/103 (25%)
		fn3	247..328	CDD:278470	19/86 (22%)
		fn3	343..417	CDD:278470	17/74 (23%)
		fn3	443..525	CDD:278470	23/81 (28%)
		FN3	548..611	CDD:238020	17/63 (27%)
		FN3	620..706	CDD:238020	21/90 (23%)
		fn3	708..796	CDD:278470	28/218 (13%)
		fn3	824..886	CDD:278470	16/63 (25%)
		fn3	902..978	CDD:278470	18/76 (24%)
		fn3	1013..1092	CDD:278470	12/78 (15%)
		UP_III_II	1106..>1248	CDD:297589	51/172 (30%)
		PTPc	1329..1582	CDD:214550	139/259 (54%)
		PTPc	1355..1582	CDD:238006	124/233 (53%)
ptprb	NP_001303656.1	FN3	113..199	CDD:238020
		fn3	216..276	CDD:306538	13/55 (24%)
		FN3	290..366	CDD:328772	21/78 (27%)
		fn3	380..453	CDD:306538	19/92 (21%)
		fn3	561..632	CDD:306538	22/82 (27%)
		FN3	647..727	CDD:328772	20/83 (24%)
		fn3	735..808	CDD:306538	17/76 (22%)
		fn3	823..896	CDD:306538	14/72 (19%)
		fn3	911..990	CDD:306538	11/78 (14%)
		FN3	1001..1081	CDD:328772	4/79 (5%)
		fn3	1090..1154	CDD:306538	19/75 (25%)
		FN3	<1190..1246	CDD:328772	17/75 (23%)
		fn3	1263..1340	CDD:306538	12/80 (15%)
		PTPc	1637..1867	CDD:238006	123/231 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	265	1.000	Domainoid score	I1858
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	446	1.000	Inparanoid score	I1609
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	1	1.000	-	-		otm25697
orthoMCL	1	0.900	-	-		OOG6_106915
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4185
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.870