Protein Alignment Ptp4E and ptprz1

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_001362251.1
• Gene: ptprz1 / 100125091
• XenbaseID: XB-GENE-1011831
• Length: 2281
• Species: Xenopus tropicalis
• Alignment Length: 1993
• Identity: 436/1993 - (21%)
• Similarity: 697/1993 - (34%)
• Gaps: 604/1993 - (30%)

  Fly    43 YQNSQQQQKHFVWLVVGILTIFLAQHANAADLVINVPNASSNANAFYRIDYSPPFGFPEPNTTIP 107
            ::..|:...|:..::.|:..:    |.....:.:. |...||....|...|   :.:....||.|
 Frog   183 FKVGQEDNVHYNEIIDGVDNV----HRFGTKVALG-PFILSNLLPDYTDKY---YTYNGSLTTPP 239

  Fly   108 ASDIGKDIKFSRALPGTE----------------YNFWLYYTNSTHREQ-----------LTWTV 145
            .|:..:.|.|...:..:|                |...:.|..:.:|.|           .|.|.
 Frog   240 CSETVEWIVFKDTVTISESQLEMFCEILTMQQSGYVMVMDYLQNNYRHQQYKFSGQVFSSYTGTE 304

  Fly   146 NITTAPDP-----PANLSVQLRSSKSAFITWRPPG------SGRYSGFRIRVLGLTDLPFERSYS 199
            .|   |:|     |.::....:::.|..||||.|.      ..||..|...:.|......|  |.
 Frog   305 EI---PEPVCSSEPEDVRADSKNNTSLLITWRRPRVVYDAVIERYLVFYQHLEGEDQTKHE--YL 364

  Fly   200 LEGNETLQLSAKELTPGGSYQVQAYSV----YQGKES---------VAYTSRNFT----TKPNTP 247
            .:|.:.|......|.|..||.:|..::    ..||.|         .|..:..||    |:.:..
 Frog   365 TDGYQDLGAIIYNLVPNTSYVLQVVAICTNGLYGKRSDQVIVDMTVDAQGTDQFTDFTETEEDIE 429

  Fly   248 GKFIVWFRNE--------TTLLVLWQPPFPAGIYT--HYRVSIT--------------PDDAIQS 288
            ....|...||        :|:....|.....|..|  .|...||              ..|.:::
 Frog   430 DSEEVEEENENKSTRIFLSTVSSTNQKQAQGGQATTSSYSEEITYVTTVKTEGDKLKEHRDVLKA 494

  Fly   289 VLY---------------------VEREGEPPGPAQAA------FKGLVPGREYNISVQTVS--- 323
            .||                     ||....|...::|.      ||..|.....|||..|.|
 Frog   495 YLYPTLQTTTKTMSDTTVGSSRKSVEHAVMPQSVSEATTYLSKDFKSRVEIWMLNISDSTQSVTE 559

  Fly   324 EDETSS------VPTTA--RYLTVPER----VLNVTFDEAYTTSSSFRVRWEPPR---------- 366
            |||.:|      ..||:  |.:.:|.|    |.|.|.|....|.|:..|....|:
 Frog   560 EDEQTSADSELHTTTTSWKRRILIPTRNPKPVSNHTTDTTPPTVSATFVSEITPQGNIVSSDIND 624

  Fly   367 --------------TYSEFDAYQVMLSTSRRIFNVPRAAN----GDSVYFDYPDI----LEPGRT 409
                          ..:|||.|::..|||..  |||..:.    .|||.....::    |..|.|
 Frog   625 YFSSTSEDIAKVTAPVTEFDLYKISTSTSTS--NVPVVSEEQHPTDSVSLHIDELLSTSLSSGAT 687

  Fly   410 YEVVVKTIADNVNS--------WPASGEVTLRP----RPVRSLGGFLDDRSNALHI--------S 454
            ......:..:.:|.        .|.|......|    ..|.:..|..|..|:...:        :
 Frog   688 VLQATASSLEEMNKATLPGKEMLPVSNTTFSTPEALLESVSASFGHHDSESSVSEVLSQATLSQT 752

  Fly   455 WEPAETGR---QDSYRISYHEQTNASEV-PAPFPVAAESQ-ITTNLTEYTLDSLL---------- 504
            .:|...|.   |.|:         .||| |...|:.:::: :...|....:|.:|
 Frog   753 TQPVSNGEIPLQPSF---------TSEVFPLVTPLLSDNKLLKATLATSDIDLILHATPVFPSVD 808

  Fly   505 ----AGRRYLIAVQALSKGVASNASDITRYTRPAAPLIQEL----RSIDQGLML----------- 550
                ....|......|:...||:.|.::.:....:.|..::    .|:...|:|
 Frog   809 VSVEPSLSYYDGAPLLAFSSASSTSKVSPHLYTVSELFSQVPTDTLSLHASLVLTESNALLQPSH 873

  Fly   551 SWRSDVNSRQDRYEVH----YQRNGTREERTMATNETSLTIHYLHPGSGYEVKVHAIS------- 604
            ::.|||...|..:..|    :...|...:::     ..|..|...|.:  |:|:||:|
 Frog   874 TYYSDVKPHQTTFGAHETLTFDHGGDTFKKS-----NKLISHLESPNT--ELKMHALSTVSELTS 931

  Fly   605 ------HGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPEGSDF----SEYVVRYRT-- 657
                  ....|...||..:.|           ||..:.:.|    :|:..    :|.:.|..|
 Frog   932 PLSSDMASSESFAVSYDSSAF-----------VHDTVGIFH----QGTIIKNLGTEVLYRPSTIS 981

  Fly   658 --DAS--PWQRI------------SGLH----------------------------ENEARIKDM 678
              |.|  |.|.|            ||.:                            ||:..||:.
 Frog   982 VPDISFQPTQSILNHEDSSDTFSGSGFYNGIDDLKVQEVVPSVSAVGDLLKTIEFIENKKVIKND 1046

  Fly   679 HYGERYLVQVNTVSFGVESPHPLELN------VTMPPQPVSNVVPLVDSRN-----LTLEWPRP- 731
            |.||.     ||....|.:..|:.|:      ..:......:.:..|:..:     |:...||.
 Frog  1047 HIGES-----NTGLQAVSAYGPVTLHAGNEEVAGLSSSDARDYIFKVEQSSQETPPLSFSTPRSF 1106

  Fly   732 DGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTT 796
            |..::..:....|           |.|:..|.:.|..|.:.|:.|...   .|.|.||.:.|.|.
 Frog  1107 DADINAASENLLP-----------VKQINTLPTTSANISLTDMLPEAS---AVSAFSNMLLSPTQ 1157

  Fly   797 HLSTRTMPLIQSDVFIANAGHEQGQDETITLSYTPTPA----DSTRFDIYRFS-------MGDPT 850
            .|.........||.|..|.    .|...:::|...|.|    |::|  .|..|       :..|:
 Frog  1158 ELFYEVSDKAVSDFFFQNV----SQSSDVSISSNVTHAELLNDASR--SYNLSSNIGSLLLPSPS 1216

  Fly   851 IKDKEKLANDTERKLSFSGLTPGKLYNVTVW-----------------TVSGGVASLPVQRLYRL 898
            ....:.|.:.|......:.|:|..:.:..:.                 ||:.|::.:..:....|
 Frog  1217 DNSIKPLLHSTYVTPVGNALSPDSVESTVLQQSVLAVHNHYVVPHLSATVNSGISYVNDKANLTL 1281

  Fly   899 HPLP--ISDLKAI-------QVAAREITLHWTAPAGEY----------TDFELQYLSADEEAPQL 944
            ..:|  .|.|.||       ....::.||::..|:..|          |:.::.|
 Frog  1282 DIVPSFFSSLHAISTPVLPTNTLTQDTTLNYNLPSYPYATHGTPAASRTNKDISY---------- 1336

  Fly   945 LQNVTKNTEITLQG-LRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPG 1008
                :.:|::|:.. |.|    |..|.|.:|..:.   ...|..|::.:::..|:......:...
 Frog  1337 ----SLSTDVTVHSLLLP----TVYVSVTAGFPKS---ESPSTLTMLTATSQTSSDILPTVSSDA 1390

  Fly  1009 KVDYFQPSDVQPG-EVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSY--------------- 1057
            |:.   ||.|..| .:...:|....|..|.:            .||.||:
 Frog  1391 KMG---PSVVDDGFIIASTYSTSHTETQGNV------------VADNSSFVHREMLKNKTFSEHS 1440

  Fly  1058 -------EFPVNATQGKIDGLVPGNHYIFRIQAKSALG-----YGAEREHIQTMPILAPPVPEPS 1110
                   .|...|....||..:.|..|:......|:.|     :.|...||||:..|
 Frog  1441 EQSEDGSAFSTAAADNNIDSDMEGESYLSTTMPMSSTGQKHIPFTAPETHIQTLNTL-------- 1497

  Fly  1111 VTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPS---------WQDV- 1165
                 :..||.:                 ||:.::..|:.|...|..:..|         :.|:
 Frog  1498 -----LENTSES-----------------RSWAVLTDEESGSGPSTSDSLSDNETSTDFNFSDIN 1540

  Fly  1166 ---QAYTVWLPYQAIEPYNPFLTSNGSRKS--SLEAEH---FTIGTANCDKHQAGYCNGPLRAGT 1222
               :.|.|     ||:|....||......|  |:.:|.   ..:..|:....:|...:...|.|.
 Frog  1541 DRDKDYEV-----AIQPGKADLTPGSEMTSPPSVTSERSPVVNVSEADVVNQEASNSSHESRVGL 1600

  Fly  1223 TYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIVAATVSAVLLVAMVLVVVY---CQHRCQLIRR 1284
            .     .....|:|   ||.          .::|.::::.:.||.:|.:::|   |.........
 Frog  1601 A-----EGLESEEK---TVI----------PLVVVSSLTFICLVVLVGILIYWRKCFQTAHFYLE 1647

  Fly  1285 ASKLAR-----------MQDELAALPEGYITPNRPVHVKDFSEHYRIMSADSDFRFSEEFEELKH 1338
            .:..:|           :.|::.|:|           :|.|.:|  :....|...|::||||:::
 Frog  1648 DNASSRVISSPPIPVFPVADDVEAIP-----------LKQFPKH--VEELHSRNGFTDEFEEIQN 1699

  Fly  1339 VGRDQACSF--ANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDG--SDYINANYMPGHNSPREFI 1399
            ...|...:.  :|.|.|:.|||:.||:.|||||.||..:.:.:|  :||||||::.|:|..:.:|
 Frog  1700 CTADLGITSDNSNHPDNKNKNRYVNIVAYDHSRVKLSQLGEKEGKATDYINANFVDGYNKQKAYI 1764

  Fly  1400 VTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHY 1464
            ..||||.||.|:||||.||.|...|||:|...||||.|||||||.|. :..||...|     ||.
 Frog  1765 AAQGPLKSTAEDFWRMLWEHNVEVIVMITNLVEKGRRKCDQYWPSDG-SEEYGSFLV-----THK 1823

  Fly  1465 HD-----WSISEFMVSRN----------CESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVI 1514
            :.     :::..|::..|          ...|.:..:|:|.|||.||||....::.|||......
 Frog  1824 NTKVLAYYTVRTFILRNNKIKKGSQKGRHNERTVVQYHYTQWPDMGVPEYTLPVLTFVRKASATK 1888

  Fly  1515 GTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQ 1579
            .....|::|||||||||:||:|.||.:|:.|.....|:|||.:..:|.:|.::||||:||:.||.
 Frog  1889 CNGNGPVVVHCSAGVGRTGTYIVLDSMLKQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYIFIHD 1953

  Fly  1580 CLLAVLEGKEHLLADSLELHANDGYEVT--------KIYLERQ 1614
            .|:..:..:|..:.:| .:|   ||..|        |..||.|
 Frog  1954 ALVEAILSRETEVPES-HIH---GYVNTLLTTGPSGKSRLETQ 1992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	73/354 (21%)
		fn3	247..328	CDD:394996	28/134 (21%)
		FN3	319..>749	CDD:442628	114/609 (19%)
		fn3	708..796	CDD:394996	18/93 (19%)
		fn3	902..978	CDD:394996	19/95 (20%)
		fn3	1013..1092	CDD:394996	19/106 (18%)
		PTP_tm	1127..1247	CDD:465889	25/137 (18%)
		R3-PTPc	1358..1579	CDD:350396	100/237 (42%)
ptprz1	NP_001362251.1	alpha_CARP_receptor_like	45..298	CDD:239396	20/122 (16%)
		fn3	313..401	CDD:394996	22/89 (25%)
		PTP_DSP_cys	1690..1960	CDD:475123	113/275 (41%)
		R-PTP-Z-2	2043..2246	CDD:350507