Protein Alignment CG4041 and TBCK

DIOPT Version :10

• Sequence 1: NP_572197.4
• Gene: CG4041 / 31422
• FlyBaseID: FBgn0029736
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001156907.2
• Gene: TBCK / 93627
• HGNCID: 28261
• Length: 893
• Species: Homo sapiens
• Alignment Length: 899
• Identity: 388/899 - (43%)
• Similarity: 520/899 - (57%)
• Gaps: 104/899 - (11%)

  Fly     8 RECRLCAVTFFAKLHPGDVCGSNGLPLTPNSIAILGRAQKLKELQDEHLCQYLDVIRGKHERTIV 72
            ::..:.|.||||...|.|||||||||||||||.||||.|.||.:....||||:|:.||||||.:|
Human     5 KDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV 69

  Fly    73 VSEYLGLSLEDYAMRHPPLAIAQILRIFYQVACGINVLSRHHLVAHNVEPKHILLSSDGQRVKLF 137
            |:|:...||||......|::.:.:|.|.::|..|:..:::|.:|...:.|.:|||...| .:||.
Human    70 VAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKG-HIKLA 133

  Fly   138 NYGLHHMTKGGAYVPFPIGNIRYMAPERLL--------------GLNGNVKSDVWSLALVMVELI 188
            .:||:|||..|..|.||||...|:|||.:.              .|....|||||||.:::.||.
Human   134 KFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWSLGIILFELC 198

  Fly   189 LQIELWPKLKLSNVVRKILAFGKSNGALEKIAREHQCHERYVQMDQRLRQLLESCLSVLPKRRPL 253
            :..:|:..|.:|..::.:|.....:..|..:|.||.|.:...::.:.:..||..||:..|.:||.
Human   199 VGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRPT 263

  Fly   254 PGELLEHPIFEEVLLDLKKQKMQPL-SPETEHLPLL---LRC----------------------- 291
            |.:|::..:|.||         .|| :|.|:...|.   |||
Human   264 PDQLMKDKVFSEV---------SPLYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAE 319

  Fly   292 -PLSQIYHLWQLAGGDVQAELKKEGLIRSEAPILGLPQIVRLSGASVCPGRSQAQLMDDRVVPLR 355
             .:.::|:||.|||||::.||..:.:|||:.||..||..:...|.|...||.::.|:||..|.|.
Human   320 RSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLS 384

  Fly   356 LKALLQRLSGLPAAVYFPLLHSPRFPAHFARELQE------LPLVIREKDIEYQFQRVRLFARLL 414
            |..|..||..:....::|||...:.....:....|      |||:|||||.|||..|:.||.|||
Human   385 LCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLL 449

  Fly   415 QGYPHTAEQLQREAAVDVPPLLRGPIWAALL--EVVPNGSYAKIDKFTSTSTDRQIEVDIPRCHQ 477
            :.||:...|:.:||.||:|||:||..|||||  |...:..|..|||.|...||||||||||||||
Human   450 KAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQ 514

  Fly   478 YDELLSSPDGHRKLRRLLKAWVTAHPQYVYWQGLDSLTAPFLYLNFNNEELAFLSLFKFIPKYLQ 542
            ||||||||:||.|.||:|||||.:||..|||||||||.|||||||||||.||:..:..||||||.
Human   515 YDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLY 579

  Fly   543 WFFLKDNSAVIKEYLSKFSQLTAFHEPLLAQHLASISFIPELFAIPWFLTMFSHVFPLHKILHLW 607
            .|||||||.||:|||:.|||:.|||:|.|:.||..|.|||:|:|||||||||:||||||||.|||
Human   580 NFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLW 644

  Fly   608 DKLMLGDSSYPLFIGIAILRQLRSTLLTSGFNECILLFSDLPDIVMDGCVLESQKMYEATPKSIT 672
            |.|:||:||:|..||:|||:|||..||.:|||||||||||||:|.::.||.||..::..||||.|
Human   645 DTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSAT 709

  Fly   673 HRQHALRLQPPQ-----------------------ALDIGVADVELKHLQQEQCPRISAKDVQFL 714
            :||||   |||:                       ..|:....:.|..|:.|..|||||:|:..|
Human   710 YRQHA---QPPKPSSDSSGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDL 771

  Fly   715 LD---------------NSPAELALIDLRSVVEFGRVHVPHSINIPFATVQLGEQRLEALQVPQL 764
            .:               :|..:|.::|:|:..:|.|.|:..||||||:.....|..|.......:
Human   772 CELTVTGHFKTPSKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAM 836

  Fly   765 EAQLRGKIVVCVSNIHQHSVEFSHFLVACGVQRTCILHKGFNVLHSIEPNILIS 818
            ....:||::|.|.::.:|:.||:..||.....|.|||..|.|   .|:|..|::
Human   837 LQNFKGKVIVIVGHVAKHTAEFAAHLVKMKYPRICILDGGIN---KIKPTGLLT 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4041	NP_572197.4	Protein Kinases, catalytic domain	48..263	CDD:473864	77/228 (34%)
		TBC	432..634	CDD:214540	140/203 (69%)
		RHOD_Kc	706..810	CDD:238783	35/118 (30%)
TBCK	NP_001156907.2	S_TKc	43..273	CDD:214567	78/230 (34%)
		TBC	467..671	CDD:214540	140/203 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	710..749		8/41 (20%)
		RHOD_Kc	771..882	CDD:238783	32/113 (28%)