DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4041 and TBC1D31

DIOPT Version :9

Sequence 1:NP_572197.4 Gene:CG4041 / 31422 FlyBaseID:FBgn0029736 Length:819 Species:Drosophila melanogaster
Sequence 2:NP_663622.2 Gene:TBC1D31 / 93594 HGNCID:30888 Length:1066 Species:Homo sapiens


Alignment Length:590 Identity:126/590 - (21%)
Similarity:211/590 - (35%) Gaps:137/590 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   198 KLSNVVR--KILAFGKSNGALEKIAREHQCHERYVQMDQRLRQLLESCLSVLPK-----RRPLPG 255
            |:..|.|  :|||.|..:..|.....|.:...|.:||..::|.:..  |..||.     ...:.|
Human   218 KVFAVTRDGRILAAGGKSNHLHLWCLEARQLFRIIQMPTKVRAIRH--LEFLPDSFDAGSNQVLG 280

  Fly   256 ELLEHPIFEEVLLDLKKQKMQ-----------PLSPETEHLPLLLRCPLSQIYHLWQLAGGDVQA 309
            .|.:..|...:.:...|...:           .:||...::..::......||        .|||
Human   281 VLSQDGIMRFINMQTCKLLFEIGSLDEGISSSAISPHGRYIASIMENGSLNIY--------SVQA 337

  Fly   310 ---ELKK---------EGLIRSEAPILGLPQIVRLSGASVCPGRSQAQLMDDRVVPLRLKALLQR 362
               |:.|         |.|.:::.....|...| .||....|.:|:...|..|:       |.|.
Human   338 LTQEINKPPPPLVKVIEDLPKNKLSSSDLKMKV-TSGRVQQPAKSRESKMQTRI-------LKQD 394

  Fly   363 LSGLPAAVYFPLLHSPRFPAHFARELQELPLVIREKDIEYQFQRVRLFARLLQGYPHTAEQLQRE 427
            |:|                 .|..:..|||..:.:|.::.          ||:||.         
Human   395 LTG-----------------DFESKKNELPDGLNKKRLQI----------LLKGYG--------- 423

  Fly   428 AAVDVPPLLRGPIWAALLEVVPNGSYAKIDKFTSTSTDRQIEVDIPRCHQYDELLSSPDGHRKLR 492
               :.|...|..||.:||::..|.:      ..||..|:...|......:     ..|...|||.
Human   424 ---EYPTKYRMFIWRSLLQLPENHT------AFSTLIDKGTHVAFLNLQK-----KYPIKSRKLL 474

  Fly   493 RLLKAWVTAHPQYVYWQGLDS-------LTAPFLYLNFNNEELAFLSLFKFIPKYLQ-WFFLKDN 549
            |:|:..::|   ..:|..:.|       |..||:.|..||:.:.|..:...|..:.| ||....|
Human   475 RVLQRTLSA---LAHWSVIFSDTPYLPLLAFPFVKLFQNNQLICFEVIATLIINWCQHWFEYFPN 536

  Fly   550 SAVIKEYLSKFSQLTAFHEPLLAQHLASISFIPELFAIPWFLTMFSHVFPLHKILHLWDKLMLGD 614
            ..:  ..||....:.|||:..|.||........:|:|.|...|:||.|....:.|.|:|.:....
Human   537 PPI--NILSMIENVLAFHDKELLQHFIDHDITSQLYAWPLLETVFSEVLTREEWLKLFDNIFSNH 599

  Fly   615 SSYPLFIGIAILRQLRSTLLTSGFNECI-LLFSDLPDIVMDGCVLESQKMYEATPKSITHRQHAL 678
            .|:.|...:|.....|:.||:....:.. ..|....::.::..:.:...:.|.||..|       
Human   600 PSFLLMTVVAYNICSRTPLLSCNLKDDFEFFFHHRNNLDINVVIRQVYHLMETTPTDI------- 657

  Fly   679 RLQPPQALDIGVADVE------------LKHLQQEQCPRISAKDVQFLLDNSPAELALIDLRSVV 731
              .|...|::.||..:            :...|.::..||...::.:|.:....|    |:::.|
Human   658 --HPDSMLNVFVALTKGQYPVFNQYPKFIVDYQTQERERIRNDELDYLRERQTVE----DMQAKV 716

  Fly   732 EFGRV 736
            :..||
Human   717 DQQRV 721

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4041NP_572197.4 PKc_like 45..272 CDD:304357 19/80 (24%)
TBC 432..634 CDD:214540 54/209 (26%)
RHOD_Kc 706..810 CDD:238783 7/31 (23%)
TBC1D31NP_663622.2 WD 1 33..74
WD40 <34..346 CDD:225201 29/137 (21%)
WD40 39..334 CDD:295369 24/125 (19%)
WD40 repeat 46..81 CDD:293791
WD 2 75..116
WD40 repeat 86..123 CDD:293791
WD 3 117..157
WD40 repeat 130..164 CDD:293791
WD 4 158..200
WD40 repeat 171..207 CDD:293791
WD 5 201..248 9/29 (31%)
WD40 repeat 215..253 CDD:293791 10/34 (29%)
WD 6 249..296 10/48 (21%)
WD40 repeat 261..291 CDD:293791 6/31 (19%)
WD 7 297..334 5/44 (11%)
WD40 repeat 309..335 CDD:293791 4/33 (12%)
RabGAP-TBC 469..609 CDD:295329 40/144 (28%)
TPH 684..960 CDD:290579 9/42 (21%)
vATP-synt_E 713..>838 CDD:304907 3/9 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 989..1020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1093
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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