Protein Alignment CG4041 and tbck

DIOPT Version :10

• Sequence 1: NP_572197.4
• Gene: CG4041 / 31422
• FlyBaseID: FBgn0029736
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001074106.2
• Gene: tbck / 791155
• ZFINID: ZDB-GENE-070112-1062
• Length: 893
• Species: Danio rerio
• Alignment Length: 882
• Identity: 386/882 - (43%)
• Similarity: 528/882 - (59%)
• Gaps: 83/882 - (9%)

  Fly     8 RECRLCAVTFFAKLHPGDVCGSNGLPLTPNSIAILGRAQKLKELQDEHLCQYLDVIRGKHERTIV 72
            |:..|.|.||||...|.|||||||||||||||.||||.|.||.:....||||:|:.||||||.::
Zfish     5 RDAELGASTFFASPLPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVI 69

  Fly    73 VSEYLGLSLEDYAMRHPPLAIAQILRIFYQVACGINVLSRHHLVAHNVEPKHILLSSDGQRVKLF 137
            |:|:...||:|...:..|::..::|::.|:|..|:..:::|.:|...:.|.::||.. ..:|||.
Zfish    70 VAEHYEKSLKDLLKQRKPVSPEKVLQVAYEVLEGLEFMNKHGMVHRALSPNNVLLDR-ADKVKLA 133

  Fly   138 NYGLHHMTKGGAYVPFPIGNIRYMAPERLL---------GLN-----GNVKSDVWSLALVMVELI 188
            .:||:|||..||.|.||||...|:.||.:.         .:|     ...|:|||||.:::.||.
Zfish   134 KFGLYHMTDHGADVDFPIGYPSYLPPEVIAQGCFYSSEPSINEAPQPSGPKTDVWSLGVLLFELC 198

  Fly   189 LQIELWPKLKLSNVVRKILAFGKSNGALEKIAREHQCHERYVQMDQRLRQLLESCLSVLPKRRPL 253
            :..::...:.:|..::.|:..|..:..:..:|.||.|.:....:.:.::.||..||:.||.:||.
Zfish   199 VGRQILQNIDISERMKFIITLGCMDDIITVLAEEHGCIDTIKDLPENVQALLRKCLTFLPSKRPT 263

  Fly   254 PGELLEHPIFEEVLLDLKKQKMQPL-----SPETEHLPL---------------LLRCPLSQIYH 298
            |.:||...:||.:..:....: .|:     ||...:|.|               |....:.::||
Zfish   264 PSDLLGDAVFESISSEYTPYQ-SPVHLFSASPRCAYLQLPDDISELCRENGENYLSERAIDEVYH 327

  Fly   299 LWQLAGGDVQAELKKEGLIRSEAPILGLPQIVRLSGASVCPGRSQAQLMDDRVVPLRLKALLQRL 363
            ||.|||||::.||..:.:|:|:.||..||:.:...|.|...||.::.|:||..|.|.|..|..||
Zfish   328 LWCLAGGDLEKELTNQEIIQSKPPICTLPKFILEDGESFGQGRDRSFLLDDTTVTLSLFQLRNRL 392

  Fly   364 SGLPAAVYFPLLHSPR--FP-AHFARELQ---ELPLVIREKDIEYQFQRVRLFARLLQGYPHTAE 422
            ..:....|||||...:  .| :..:.||.   .|||:|||:|.|||..|:.||.|||:.||:...
Zfish   393 KDVAGETYFPLLEDEQCSLPQSSSSNELSATVTLPLIIRERDTEYQLTRIVLFHRLLKAYPYKKN 457

  Fly   423 QLQREAAVDVPPLLRGPIWAALLEVVPN--GSYAKIDKFTSTSTDRQIEVDIPRCHQYDELLSSP 485
            |:.:||.||:||||||..|||||.|..:  ..|..|||.|...||||||||||||||||||||||
Zfish   458 QIWKEARVDIPPLLRGLAWAALLGVEGDIQSKYDSIDKDTPIPTDRQIEVDIPRCHQYDELLSSP 522

  Fly   486 DGHRKLRRLLKAWVTAHPQYVYWQGLDSLTAPFLYLNFNNEELAFLSLFKFIPKYLQWFFLKDNS 550
            .||.|.||:|||||.:||..|||||||||.|||||||||||.||:..:..||||||..|||||||
Zfish   523 QGHVKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNS 587

  Fly   551 AVIKEYLSKFSQLTAFHEPLLAQHLASISFIPELFAIPWFLTMFSHVFPLHKILHLWDKLMLGDS 615
            .||:|||:.|||:.|||:|.|:.||..|.|||:|:|||||||||:||||||||.||||.|:||:|
Zfish   588 HVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNS 652

  Fly   616 SYPLFIGIAILRQLRSTLLTSGFNECILLFSDLPDIVMDGCVLESQKMYEATPKSITHRQHALRL 680
            |:|..||:|||:|||..||.:|||||||||||||:|.::.||.||..::..||||.|:||||...
Zfish   653 SFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPN 717

  Fly   681 QPP-----------------QAL---DIGVADVELKHLQQEQCPRISAKDVQFLLD-NSPA---- 720
            :||                 |.|   |:....::|..|:.|..||||.:|:..|.: :.||
Zfish   718 KPPSESNSFGKTPSYYASEFQELTKTDLSREPLKLSELKAEVSPRISVEDLIDLCELSGPAFFKT 782

  Fly   721 ----------ELALIDLRSVVEFGRVHVPHSINIPFATVQLGEQRLEALQVPQLE--AQLRGKIV 773
                      ::..:|:||:.:|.|.|:..|||||: |...|.:. |.||.|...  |..|.:::
Zfish   783 PVKRARTGKPKILAVDIRSLEDFSRGHIYGSINIPY-TSTFGPEG-ELLQCPASSSLAGYRLRVI 845

  Fly   774 VCVSNIHQHSVEFSHFLVACGVQRTCILHKGFNVLHS 810
            |.:|::.::::.|:..||.....|.|:|..|.|.:.|
Zfish   846 VILSSVMKNAITFATHLVKVNFPRVCVLDGGMNKMKS 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4041	NP_572197.4	Protein Kinases, catalytic domain	48..263	CDD:473864	73/228 (32%)
		TBC	432..634	CDD:214540	141/203 (69%)
		RHOD_Kc	706..810	CDD:238783	35/120 (29%)
tbck	NP_001074106.2	Protein Kinases, catalytic domain	43..268	CDD:473864	72/225 (32%)
		TBC	467..671	CDD:214540	141/203 (69%)
		RHOD	788..882	CDD:444705	29/95 (31%)