DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4041 and plx

DIOPT Version :9

Sequence 1:	NP_572197.4	Gene:	CG4041 / 31422	FlyBaseID:	FBgn0029736	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001163511.1	Gene:	plx / 40704	FlyBaseID:	FBgn0261261	Length:	1572	Species:	Drosophila melanogaster

Alignment Length:	731	Identity:	149/731 - (20%)
Similarity:	245/731 - (33%)	Gaps:	204/731 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 SLALVMVELILQIE---LWPKLKLSNVVRKILAFGKSNGALEKIAREH-------QCHERYVQMD 233
            :|.|..:|.:...|   :|.|...|......:|  :.|..|..:.|.|       ..|:......
  Fly   643 ALILRRIETLSDDEQEIVWAKFCGSEKTNSPVA--EQNQFLMMLLRAHCESRQQRHVHDTAENRS 705

  Fly   234 QRLRQLLESCLSVLPKRRPLPGE----LLEHPIFEEV------LLDLKKQKMQPL---------- 278
            :.|.|.|......:..:|.|...    |...|..:::      |.|:::...:||
  Fly   706 EFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKPSKDDIAVPSHNLRDIREGSAEPLGTQSPPEGFR 770

  Fly   279 --------SPETEHLPLLLRCPLSQIYHLWQLAGGDVQAELKKEGLIRSEAPILGLPQIVRLSGA 335
                    ||.::.....|:.|:..|:    :..|:...|                        |
  Fly   771 SRSNTVGASPSSKPTAEQLKSPMMDIF----IKVGNSPKE------------------------A 807

  Fly   336 SVCPGRSQAQLMDDRVVPLRLKALLQRLSGLPAAVYFPLLHSPRFPA----HFARELQEL----- 391
            ....|..:..:::..|.|.:         ||.:.|....|...|.||    ..|.||:||
  Fly   808 ETHQGSWRQAILNSVVTPSK---------GLDSEVPTEFLSPMRKPAKRGKRDAAELRELWRTAI 863

  Fly   392 ------------PLVIREKDIEYQFQRVRL--------FARLLQGYPHTAEQ------------- 423
                        ..:::.:..|.:.:|::|        ..:|::.:....|:
  Fly   864 RQTIMLNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKV 928

  Fly   424 LQREAAVDVPPLLRGPIWAALLE-----VVP---------NGSYAKIDKFTSTSTDRQIEVDIPR 474
            |.......||...||.:|..|.|     ..|         |..|..:.|.. |.....|.:|:.|
  Fly   929 LGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHL-TEHQHAIFIDLGR 992

  Fly   475 CHQYDELLSSP--DGHRKLRRLLKAWVTAHPQYVYWQGLDSLTAPFLYLNFNNEELAFLSLFKFI 537
            .....:....|  .|...|..||||:....|:..|.|||..:....|   .:.:|.....|.|.:
  Fly   993 TFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLL---LHCDEANSFQLLKHL 1054

  Fly   538 --PKYLQWFFLKDNSAVIKEY---LSKFSQLTAFHEPLLAQHLASISFIPELFAIPWFLTMFSHV 597
              .:.::..:|.|    :|::   |.:.|:|...|.|.|...|......|.|:|.||.||:||..
  Fly  1055 MFRRNMRTKYLPD----MKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQ 1115

  Fly   598 FPLHKILHLWDKLMLGDSSYPLFIGIAILRQLRSTLLT-SGFNE---------------CI---- 642
            |||..:..::|.|.|..|.......||:|...:..||. ..|.|               |:
  Fly  1116 FPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIM 1180

  Fly   643 -LLFSDLPDIVMD-GCVLESQKM-YEATPKSITHRQHALRLQPPQALDIGVADVELKHLQQE-QC 703
             |:||      || |..|...|: |....:.||...|.|.:       :.....:.:||:|: |.
  Fly  1181 KLVFS------MDIGKQLAEYKVEYNVLQEEITTTNHHLEM-------LNREKTQNQHLEQQLQF 1232

  Fly   704 PRISAKDVQFLLDNSPAELALIDLR------SVVEFGRV------HVPHSINIPFATVQLGEQRL 756
            .:.|...::....:..|::..:..:      ::...||.      |.| .:.:|      .|.|.
  Fly  1233 AQSSIAQLETTRSSQQAQITTLQSQVQSLELTIQTLGRYVGQLVEHNP-DLELP------NEVRR 1290

  Fly   757 EALQVPQLEAQLRGKI 772
            ...|:..|:.|.|..|
  Fly  1291 MLQQLDDLDRQRRKPI 1306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4041	NP_572197.4	PKc_like	45..272	CDD:304357	22/112 (20%)
		TBC	432..634	CDD:214540	60/222 (27%)
		RHOD_Kc	706..810	CDD:238783	14/79 (18%)
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	835..880	CDD:288663	9/44 (20%)
		TBC	933..1152	CDD:214540	60/226 (27%)
		RILP-like	<1176..1267	CDD:304877	19/103 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456514
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940