DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4041 and Tbc1d31

DIOPT Version :9

Sequence 1:	NP_572197.4	Gene:	CG4041 / 31422	FlyBaseID:	FBgn0029736	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001128314.1	Gene:	Tbc1d31 / 299949	RGDID:	1587370	Length:	1061	Species:	Rattus norvegicus

Alignment Length:	678	Identity:	136/678 - (20%)
Similarity:	233/678 - (34%)	Gaps:	207/678 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 NVVRKILAFGKSNGALEKIAREHQCH---------ERYVQMDQRLRQLLESCLSVLPK-----RR 251
            |::.|:.|..:....|....:.:..|         .|.:||..::|.:..  |..||.     ..
  Rat   214 NILYKVFAVTRDGRILAAGGKSNHVHLWCLEATQLFRIIQMPTKVRAVRH--LEFLPDSFDAGSN 276

  Fly   252 PLPGELLEHPIFEEVLLDLKKQKMQ-----------PLSPETEHLPLLLRCPLSQIYHLWQLAGG 305
            .:.|.|.:..|...|.:...|...|           .:||...::..::......:|
  Rat   277 QVLGVLSQDGIMRFVNIQTCKLLFQIGTVEEGVSSSVISPHGRYITAIMENGSLNVY-------- 333

  Fly   306 DVQAELKKEGLIRSEAPILGLPQIVRLSGASVCPGRSQAQLMDDRVV-PLRLK-------ALLQR 362
            .||| |.:|  |....|.| :..|..|...:|.....:.::|..||. |.|.|       .|.|.
  Rat   334 SVQA-LTQE--INKPPPPL-VKVIEDLPNNTVSSNNLKVKVMSGRVQRPARCKERKNQTRVLKQD 394

  Fly   363 LSGLPAAVYFPLLHSPRFPAHFARELQELPLVIREKDIEYQFQRVRLFARLLQGYPHTAEQLQRE 427
            |:|                          .|..:|.::.....:.||.. ||:||.
  Rat   395 LTG--------------------------NLENKENELSEGLNKKRLQV-LLKGYG--------- 423

  Fly   428 AAVDVPPLLRGPIWAALLEVVPNGS--YAKIDKFTSTSTDRQIEVDIPRCHQYDELLSSPDGHRK 490
               :.|...|..||.:||::..|.:  .:.:||.|..:     .:|:.:.:        |...|:
  Rat   424 ---EYPTKYRMFIWRSLLQLPENHTAFSSLMDKGTHAA-----YLDLQKKY--------PIKSRR 472

  Fly   491 LRRLLKAWVTAHPQYVYWQGLDS-------LTAPFLYLNFNNEELAFLSLFKFIPKYLQ-WFFLK 547
            |.|:|:..::|   ..:|..:.|       |..||:.|..||:.:.|..:...|..:.| ||...
  Rat   473 LLRVLQRTLSA---LAHWSAIFSDMPYLPLLAFPFVKLFQNNQLICFEVVATLIINWCQHWFEYF 534

  Fly   548 DNSAVIKEYLSKFSQLTAFHEPLLAQHLASISFIPELFAIPWFLTMFSHVFPLHKILHLWDKLML 612
            .|..:  ..|:....:.|||:..|.||........:::|.|...|:||.|....:.|.|:|.:.
  Rat   535 PNPPI--NILTMIENVLAFHDKELLQHFIDRDITSQVYAWPLLETLFSEVLTREEWLRLFDNIF- 596

  Fly   613 GDSSYPLFIGIAILRQ---LRSTLLTSGFNECIL------LFSDLPDIVMDGCVLESQKMYEATP 668
              ||:|.|:.:.::..   .|:.||     .|.|      .|....::.::..:.|...:.|.||
  Rat   597 --SSHPSFLLMTVVAYNTCSRAPLL-----NCTLKDDFEYFFHHRNNLDLNVVIREVYHLMETTP 654

  Fly   669 KSI------------THRQHALRLQPPQALDIGVADVELKHLQQEQCPRISAKDVQFL-----LD 716
            ..|            |..|:.:..|.|:.    :.|.:.|..:     ||...::.||     ::
  Rat   655 ADIHPNSMLDAFVALTKGQYPIFNQYPKF----IVDYQTKERE-----RIRNDELDFLRERQTVE 710

  Fly   717 NSPAEL----------------------------------------ALIDLRSVVEFGRVHVPHS 741
            |..||:                                        .|..::..:|...:|:..:
  Rat   711 NMQAEVDEQRAKDEAWYQKQEMLRRAEETRREMLLQEEEKMAQQRHRLAAVKRELEIKEIHLQDA 775

  Fly   742 INIPFATVQLGEQRLEALQVPQLEAQLR 769
                      ..:||..||..|.|.:||
  Rat   776 ----------ARRRLLKLQQDQREMELR 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4041	NP_572197.4	PKc_like	45..272	CDD:304357	16/84 (19%)
		TBC	432..634	CDD:214540	52/214 (24%)
		RHOD_Kc	706..810	CDD:238783	17/109 (16%)
Tbc1d31	NP_001128314.1	WD40	<34..346	CDD:225201	27/144 (19%)
		WD40	39..334	CDD:295369	21/129 (16%)
		WD40 repeat	43..81	CDD:293791
		WD40 repeat	86..123	CDD:293791
		WD40 repeat	130..164	CDD:293791
		WD40 repeat	171..207	CDD:293791
		WD40 repeat	215..253	CDD:293791	5/37 (14%)
		WD40 repeat	261..290	CDD:293791	6/30 (20%)
		RabGAP-TBC	460..609	CDD:295329	41/164 (25%)
		ARGLU	693..842	CDD:291991	18/116 (16%)
		vATP-synt_E	713..>834	CDD:304907	13/91 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1093
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900