Protein Alignment CG4041 and Tbck

DIOPT Version :10

• Sequence 1: NP_572197.4
• Gene: CG4041 / 31422
• FlyBaseID: FBgn0029736
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001401962.1
• Gene: Tbck / 295446
• RGDID: 1307816
• Length: 894
• Species: Rattus norvegicus
• Alignment Length: 900
• Identity: 387/900 - (43%)
• Similarity: 518/900 - (57%)
• Gaps: 105/900 - (11%)

  Fly     8 RECRLCAVTFFAKLHPGDVCGSNGLPLTPNSIAILGRAQKLKELQDEHLCQYLDVIRGKHERTIV 72
            ::..:.|.||||...|.|||||||||||||||.||||.|.||.:....||||:|:.||||||.:|
  Rat     5 KDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQVLKTITHPRLCQYVDISRGKHERLVV 69

  Fly    73 VSEYLGLSLEDYAMRHPPLAIAQILRIFYQVACGINVLSRHHLVAHNVEPKHILLSSDGQRVKLF 137
            |:|:...||||......|.:.:.:|.|.|:|..|:..|::|.:|...:.|.:|||...| .:||.
  Rat    70 VAEHCERSLEDLLRERRPASHSAVLCIAYEVLEGLQYLNKHGIVHRALSPHNILLDRKG-HIKLA 133

  Fly   138 NYGLHHMTKGGAYVPFPIGNIRYMAPERLL--------------GLNGNVKSDVWSLALVMVELI 188
            .:||:|||..|..|.||||...|:|||.:.              .|....|||||||.:::.||.
  Rat   134 KFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKSTDHVPSEKPLPSGPKSDVWSLGIILFELC 198

  Fly   189 LQIELWPKLKLSNVVRKILAFGKSNGALEKIAREHQCHERYVQMDQRLRQLLESCLSVLPKRRPL 253
            :..:|:..|.:|..::.:|..|..:..|..:|.||.|.:...::.:....:|:.||:..|.:||.
  Rat   199 VGRKLFQSLDISERLKFLLTLGCVDDTLIVLAEEHGCLDIIKELPENALSILKKCLTFHPPKRPT 263

  Fly   254 PGELLEHPIFEEVLLDLKKQKMQPL-SPETEHLPLL---LRC----------------------- 291
            |.||::..:|.||         .|| :|..:...|.   |||
  Rat   264 PDELMKDQVFSEV---------SPLYTPFIKPASLFSSSLRCADLTLPEDISDVCKDIDDDYLAE 319

  Fly   292 -PLSQIYHLWQLAGGDVQAELKKEGLIRSEAPILGLPQIVRLSGASVCPGRSQAQLMDDRVVPLR 355
             .:.::|:||.|||||::.||..:.:|||:.||..||..:...|.|...||.::.|:||..|.|.
  Rat   320 RSIEEVYYLWCLAGGDLEKELINKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLS 384

  Fly   356 LKALLQRLSGLPAAVYFPLLHSPRFPAHFARELQE------LPLVIREKDIEYQFQRVRLFARLL 414
            |..|..||..:....::|||...:.....:....|      |||:|||:|.|||..|:.||.|||
  Rat   385 LCQLRNRLKDVGGEAFYPLLEDDQSSLPHSNSNNELSAAASLPLIIRERDTEYQLNRIILFDRLL 449

  Fly   415 QGYPHTAEQLQREAAVDVPPLLRGPIWAALL--EVVPNGSYAKIDKFTSTSTDRQIEVDIPRCHQ 477
            :.||:...|:.:||.||:|||:||..|||||  |...:..|..|||.|...||||||||||||||
  Rat   450 KAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQ 514

  Fly   478 YDELLSSPDGHRKLRRLLKAWVTAHPQYVYWQGLDSLTAPFLYLNFNNEELAFLSLFKFIPKYLQ 542
            ||||||||:||.|.||:|||||.:||..|||||||||.|||||||||||.||:..:..||||||.
  Rat   515 YDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLY 579

  Fly   543 WFFLKDNSAVIKEYLSKFSQLTAFHEPLLAQHLASISFIPELFAIPWFLTMFSHVFPLHKILHLW 607
            .|||||||.||:|||:.|||:.:||:|.|:.||..|.|||:|:|||||||||:||||||||.|||
  Rat   580 NFFLKDNSHVIQEYLTVFSQMISFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLW 644

  Fly   608 DKLMLGDSSYPLFIGIAILRQLRSTLLTSGFNECILLFSDLPDIVMDGCVLESQKMYEATPKSIT 672
            |.|:||:||:|..||:|||:|||..||.:|||||||||||||:|.::.||.||..::..||||.|
  Rat   645 DTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESVNLFCWTPKSAT 709

  Fly   673 HRQHALRLQPPQ------------------------ALDIGVADVELKHLQQEQCPRISAKDVQF 713
            :||||   |||:                        ..|:....:.|..|:.|..|||||:|:..
  Rat   710 YRQHA---QPPRPASESSAVRSSSAPYFSAECTDPPKTDLSRESIPLSDLKSEVSPRISAEDLID 771

  Fly   714 LLD---------------NSPAELALIDLRSVVEFGRVHVPHSINIPFATVQLGEQRLEALQVPQ 763
            |.:               :|..:|.::|:|:..:|.|.|:..||||||:.....|..|.......
  Rat   772 LCELTVTGHFKTPTKKTKSSKPKLLVVDIRNSEDFLRGHIAGSINIPFSAAFTAEGELSQGPYTT 836

  Fly   764 LEAQLRGKIVVCVSNIHQHSVEFSHFLVACGVQRTCILHKGFNVLHSIEPNILIS 818
            :....:||::|.|.::.:.:.||:..||.....|.|||..|.|   .|:|..|::
  Rat   837 MLHSFKGKVIVIVGHVAKQTSEFAAHLVKMKYPRVCILDGGIN---KIKPTGLLT 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4041	NP_572197.4	Protein Kinases, catalytic domain	48..263	CDD:473864	80/228 (35%)
		TBC	432..634	CDD:214540	139/203 (68%)
		RHOD_Kc	706..810	CDD:238783	34/118 (29%)
Tbck	NP_001401962.1	Protein Kinases, catalytic domain	43..273	CDD:473864	81/230 (35%)
		TBC	467..671	CDD:214540	139/203 (68%)
		RHOD	772..883	CDD:444705	31/113 (27%)