Protein Alignment CG4041 and Tbck

DIOPT Version :9

• Sequence 1: NP_572197.4
• Gene: CG4041 / 31422
• FlyBaseID: FBgn0029736
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001156927.1
• Gene: Tbck / 271981
• MGIID: 2445052
• Length: 893
• Species: Mus musculus
• Alignment Length: 899
• Identity: 387/899 - (43%)
• Similarity: 520/899 - (57%)
• Gaps: 104/899 - (11%)

  Fly     8 RECRLCAVTFFAKLHPGDVCGSNGLPLTPNSIAILGRAQKLKELQDEHLCQYLDVIRGKHERTIV 72
            ::..:.|.||||...|.|||||||||||||||.||||.|.||.:....||||:|:.||||||.:|
Mouse     5 KDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV 69

  Fly    73 VSEYLGLSLEDYAMRHPPLAIAQILRIFYQVACGINVLSRHHLVAHNVEPKHILLSSDGQRVKLF 137
            |:|:...||||......|::.:.:|.|.|:|..|::.|::|.:|...:.|.:|||...| .:||.
Mouse    70 VAEHCERSLEDLLRERKPVSHSTVLCIAYEVLEGLHYLNKHGIVHRALSPHNILLDRKG-HIKLA 133

  Fly   138 NYGLHHMTKGGAYVPFPIGNIRYMAPERLL--------------GLNGNVKSDVWSLALVMVELI 188
            .:||:|||..|..|.||||...|:|||.:.              .|....|||||||.:::.||.
Mouse   134 KFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIPKTTDHVPSEKPLPSGPKSDVWSLGIILFELC 198

  Fly   189 LQIELWPKLKLSNVVRKILAFGKSNGALEKIAREHQCHERYVQMDQRLRQLLESCLSVLPKRRPL 253
            :..:|:..|.:|..|:.:|..|..:..:..:|.||.|.:...::.:.:..:|:.||:..|.:||.
Mouse   199 VGRKLFQSLDVSERVKFLLTLGCVDDTIIVLAEEHGCLDIIKELPENVINILKKCLTFHPSKRPT 263

  Fly   254 PGELLEHPIFEEVLLDLKKQKMQPL-SPETEHLPLL---LRC----------------------- 291
            |.||::..:|.||         .|| :|..:...|.   |||
Mouse   264 PDELMKDQVFSEV---------SPLYTPFIKPASLFSSSLRCADLTLPEDISDLCKDIDNDYLAE 319

  Fly   292 -PLSQIYHLWQLAGGDVQAELKKEGLIRSEAPILGLPQIVRLSGASVCPGRSQAQLMDDRVVPLR 355
             .:.::|:||.|||||::.||..:.:|||:.|:..||..:...|.|...||.::.|:||..|.|.
Mouse   320 RSIEEVYYLWCLAGGDLEKELINKEIIRSKPPVCTLPNFLFEDGESFGQGRDRSSLLDDTTVTLS 384

  Fly   356 LKALLQRLSGLPAAVYFPLLHSPRFPAHFARELQE------LPLVIREKDIEYQFQRVRLFARLL 414
            |..|..||..:....::|||...:.....:....|      |||:|||:|.|||..|:.||.|||
Mouse   385 LCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIRERDTEYQLNRIILFDRLL 449

  Fly   415 QGYPHTAEQLQREAAVDVPPLLRGPIWAALL--EVVPNGSYAKIDKFTSTSTDRQIEVDIPRCHQ 477
            :.||:...|:.:||.||:|||:||..|||||  |...:..|..|||.|...||||||||||||||
Mouse   450 KAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQ 514

  Fly   478 YDELLSSPDGHRKLRRLLKAWVTAHPQYVYWQGLDSLTAPFLYLNFNNEELAFLSLFKFIPKYLQ 542
            ||||||||:||.|.||:|||||.:||..|||||||||.|||||||||||.||:..:..||||||.
Mouse   515 YDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLY 579

  Fly   543 WFFLKDNSAVIKEYLSKFSQLTAFHEPLLAQHLASISFIPELFAIPWFLTMFSHVFPLHKILHLW 607
            .|||||||.||:|||:.|||:.|||:|.|:.||..|.|||:|:|||||||||:||||||||.|||
Mouse   580 NFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLW 644

  Fly   608 DKLMLGDSSYPLFIGIAILRQLRSTLLTSGFNECILLFSDLPDIVMDGCVLESQKMYEATPKSIT 672
            |.|:||:||:|..||:|||:|||..||.:|||||||||||||:|.::.||.||..::..||||.|
Mouse   645 DTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESVNLFCWTPKSAT 709

  Fly   673 HRQHALRLQPPQ-----------------------ALDIGVADVELKHLQQEQCPRISAKDVQFL 714
            :||||   |||:                       ..|:....:.|..|:.|..|||||:|:..|
Mouse   710 YRQHA---QPPKPASESSVVRSSAPYFSAECTDPPKTDLSRESIPLSDLKSEVSPRISAEDLIDL 771

  Fly   715 LD---------------NSPAELALIDLRSVVEFGRVHVPHSINIPFATVQLGEQRLEALQVPQL 764
            .:               :|..:|.::|:|:..:|.|.|:..||||||:.....|..|.......:
Mouse   772 CELTVTGHFKTPTKKTKSSKPKLLVVDIRNSEDFVRGHIAGSINIPFSAAFTAEGELSQGPYTTM 836

  Fly   765 EAQLRGKIVVCVSNIHQHSVEFSHFLVACGVQRTCILHKGFNVLHSIEPNILIS 818
            ....:||::|.|.::.:.:.||:..||.....|.|||..|.|   .|.|..|::
Mouse   837 LHNFKGKVIVVVGHVAKQTAEFAAHLVKMKYPRVCILDGGIN---KIRPTGLLT 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4041	NP_572197.4	PKc_like	45..272	CDD:304357	84/240 (35%)
		TBC	432..634	CDD:214540	140/203 (69%)
		RHOD_Kc	706..810	CDD:238783	34/118 (29%)
Tbck	NP_001156927.1	S_TKc	43..273	CDD:214567	81/230 (35%)
		PKc_like	43..271	CDD:304357	81/228 (36%)
		TBC	467..671	CDD:214540	140/203 (69%)
		RHOD	771..882	CDD:294087	31/113 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849992
Domainoid	1	1.000	286	1.000	Domainoid score	I1597
eggNOG	1	0.900	-	-		E1_KOG1093
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13221
Inparanoid	1	1.050	626	1.000	Inparanoid score	I858
Isobase	1	0.950	-	0	Normalized mean entropy	S3366
OMA	1	1.010	-	-		QHG55921
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006493
OrthoInspector	1	1.000	-	-		oto94391
orthoMCL	1	0.900	-	-		OOG6_104373
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3699
SonicParanoid	1	1.000	-	-		X5470
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740