DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4041 and Tbc1d31

DIOPT Version :9

Sequence 1:	NP_572197.4	Gene:	CG4041 / 31422	FlyBaseID:	FBgn0029736	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_006520761.1	Gene:	Tbc1d31 / 210544	MGIID:	2684931	Length:	1061	Species:	Mus musculus

Alignment Length:	674	Identity:	138/674 - (20%)
Similarity:	228/674 - (33%)	Gaps:	197/674 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 SNVVRKILAFGKSNGALEKIAREHQCH---------ERYVQMDQRLRQLLESCLSVLPK-----R 250
            ||::.|:.|..:....|....:.:..|         .|.:||..::|.:..  |..||.     .
Mouse   213 SNILYKVFAVTRDGRILAAGGKSNHLHLWCLEATGLFRIIQMPAKVRAVRH--LEFLPDSFDAGS 275

  Fly   251 RPLPGELLEHPIFEEVLLDLKKQKMQ-----------PLSPETEHLPLLLRCPLSQIYHLWQLAG 304
            ..:.|.|.:..|...|.:...|...:           .:||...::..::......:|
Mouse   276 NQVLGVLSQDGIMRFVNIQTCKLLFEIGTVEEGISSSVISPHGRYIASIMENGSLNVY------- 333

  Fly   305 GDVQAELKKEGLIRSEAP-----ILGLPQIVRLSG---ASVCPGRSQ--AQLMDDRVVPLRLKAL 359
             .||| |.:|  |....|     |..||.....|.   ..:.|||.|  |:..:.: :|.|:  |
Mouse   334 -SVQA-LTQE--INKPPPPLVKVIEDLPSNTVSSSNLKMKIMPGRVQRPARCKESK-IPTRV--L 391

  Fly   360 LQRLSGLPAAVYFPLLHSPRFPAHFARELQELPLVIREKDIEYQFQRVRLFARLLQGYPHTAEQL 424
            .|.|:|                     :|:.     :|.::.....:.|| ..||:||.
Mouse   392 KQDLTG---------------------DLEN-----KENELSEGLNKKRL-QILLKGYG------ 423

  Fly   425 QREAAVDVPPLLRGPIWAALLEVVPNGS--YAKIDKFTSTSTDRQIEVDIPRCHQYDELLSS-PD 486
                  :.|...|..||.:||::..|.:  .:.:||.|..:              |..|... |.
Mouse   424 ------EYPTKYRMFIWRSLLQLPENHTAFSSLVDKGTHAA--------------YLSLQKKYPI 468

  Fly   487 GHRKLRRLLKAWVTAHPQYVYWQGLDS-------LTAPFLYLNFNNEELAFLSLFKFIPKYLQ-W 543
            ..|||.|:|:..::|   ..:|..:.|       |..||:.|..||:.:.|..:...|..:.| |
Mouse   469 KSRKLLRVLQRTLSA---LAHWSAIFSDTPYLPLLAFPFVKLFQNNQLICFEVVATLIINWCQHW 530

  Fly   544 FFLKDNSAVIKEYLSKFSQLTAFHEPLLAQHLASISFIPELFAIPWFLTMFSHVFPLHKILHLWD 608
            |....|..:  ..||....:.|||:..|.||........:::|.|...|:||.|....:.|.|:|
Mouse   531 FEYFPNPPI--NILSMIENVLAFHDKELLQHFIDRDITSQVYAWPLLETLFSEVLTREEWLRLFD 593

  Fly   609 KLMLGDSSYPLFIGIAILRQLRSTLLTSGF-NECILLFSDLPDIVMDGCVLESQKMYEATPKSIT 672
            .:.....|:.|...:|.....|:.||.... |:....|....::.::..:.|...:.|.||..|
Mouse   594 NIFSNHPSFLLMTVVAYSTCSRAPLLNCTLKNDFEYFFHHRNNLDINVVIREVYHLMETTPADI- 657

  Fly   673 HRQHALRLQPPQALDIGVADVE------------LKHLQQEQCPRISAKDVQFL-----LDNSPA 720
                    .|...||..||..:            :...|..:..||...::.||     ::|..|
Mouse   658 --------HPNSMLDAFVALTKGQYPIFNQYPKFIVDYQTREWERIRNDELDFLRERQTVENMQA 714

  Fly   721 EL----------------------------------------ALIDLRSVVEFGRVHVPHSINIP 745
            |:                                        .|..::..:|...:|:..:
Mouse   715 EVDEQRAKDEAWYQKQELLRRAEETRREILLQEEEKMAQQRQRLAAVKRELEIKEIHLQDA---- 775

  Fly   746 FATVQLGEQRLEALQVPQLEAQLR 769
                  ..:||..||..|.|.:||
Mouse   776 ------ARRRLLKLQQDQREMELR 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4041	NP_572197.4	PKc_like	45..272	CDD:304357	17/85 (20%)
		TBC	432..634	CDD:214540	54/212 (25%)
		RHOD_Kc	706..810	CDD:238783	17/109 (16%)
Tbc1d31	XP_006520761.1	WD40	39..334	CDD:392136	21/130 (16%)
		WD40 repeat	43..81	CDD:293791
		WD40 repeat	86..123	CDD:293791
		WD40 repeat	131..164	CDD:293791
		WD40 repeat	171..211	CDD:293791
		WD40 repeat	219..255	CDD:293791	5/35 (14%)
		WD40 repeat	261..290	CDD:293791	6/30 (20%)
		RabGAP-TBC	428..619	CDD:382990	53/209 (25%)
		DUF5401	<684..>1006	CDD:375164	19/120 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1093
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900