Protein Alignment CG4041 and tbck-1

DIOPT Version :10

• Sequence 1: NP_572197.4
• Gene: CG4041 / 31422
• FlyBaseID: FBgn0029736
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001364726.1
• Gene: tbck-1 / 173832
• WormBaseID: WBGene00016352
• Length: 839
• Species: Caenorhabditis elegans
• Alignment Length: 903
• Identity: 245/903 - (27%)
• Similarity: 388/903 - (42%)
• Gaps: 180/903 - (19%)

  Fly     4 RERERECRLCAVTFFAKLHPGDVCGSNGLPLTPNSIAILGRAQKLKELQDEHLCQYL----DVIR 64
            |.:|::.|.|.               ||||:...:..:|||...|:.||.::|..||    .||
 Worm    13 RAQEKDGRTCI---------------NGLPVASPAKQMLGRFPYLQSLQHDNLSVYLHFSETVI- 61

  Fly    65 GKHERTIVVSEYLGLSLEDYAMRHPPLAIAQILRIFY-QVACGINVLSRHHLVAHNVEPKHILLS 128
             ..:..|||.|:..::||| .::...|....:...|| :::..::.|...::| |.....:.:..
 Worm    62 -ARDLVIVVMEHYTMNLED-ILKTGNLKDESLNNNFYSEISSALDYLHTRNIV-HGFLHLNSIYI 123

  Fly   129 SDGQR----VKLFNYGLHHMTKGGAYVPFPIGNIRYMAPERLLG-----LNGNVKSDVWSLALVM 184
            :|.:.    |||..|||..:|..|......|....::||||:|.     .....:||||.|..::
 Worm   124 TDRKNQKLSVKLSGYGLPFLTNYGKDTASSIKFGAFLAPERILNDEDSLFAATYQSDVWELGFII 188

  Fly   185 VELILQIELWPKL------------------KLSNVVRKILAFGKSNGALEKIAREHQC--HERY 229
            :::.|.|.|..::                  |||.|:..:         ::.:|.:.:.  |::.
 Worm   189 LQIYLGISLEAEVTETEYLEILNKYYTDDQEKLSTVMEDL---------IQLLADKKRLPYHKKC 244

  Fly   230 VQMDQRLRQLLESCLSVLPKRRPLPGEL-------------LEHPI--FEEVLLDLKKQ------ 273
            ..::..:|:.|:.|.|.......:..|:             .|:.:  .||:...::|:
 Worm   245 EWLEAIIRKCLQMCCSKRCSITEVAAEIEININGVKNNNNKYEYKVKTVEEMRAAVRKEVADNND 309

  Fly   274 KMQPLSPETEHLPLLLRCPLSQIYHLWQLAGGDVQAELKKEGLIRSEAPILGLPQI-----VRLS 333
            ..:.||.|..             ::||:..|...:..|.|:|:|::.|||...|.:     :||.
 Worm   310 GFEKLSVENS-------------FYLWKTCGSTPEIILLKKGIIQNHAPISSYPTVRFDDFLRLD 361

  Fly   334 GASVCPGRSQAQLMDDRVVPLRLKALL------QRLSGLPAAVYFPLLHSPRFPAHFARELQELP 392
            .     |.......:..|..|..|..|      ||:|                    ||...::.
 Worm   362 S-----GVDSQSTFEYGVFDLPSKKTLTRKETGQRVS--------------------ARMFHKIG 401

  Fly   393 LVIREKDIEYQFQRVRLFARLLQG---YPHTAEQL------------------QREAAVDVPPLL 436
             ::.:||             ||.|   |...:..|                  .|...:.|.|..
 Worm   402 -ILEDKD-------------LLNGNILYETASNMLTVDHLLNASAVFGISSIISRLTNIGVIPTQ 452

  Fly   437 RGPIWAALLEVVPN--GSYAKIDKFTSTSTDRQIEVDIPRCHQYDELLSSPDGHRKLRRLLKAW- 498
            |..:|..||::...  ..|..:|...|.|:|||:|||||||||||..:::|.....||::||.|
 Worm   453 RADVWCTLLDINETKWRDYLNLDVLASHSSDRQLEVDIPRCHQYDSYMTTPAIQESLRKVLKGWQ 517

  Fly   499 -VTAHPQYVYWQGLDSLTAPFLYLNFNNEELAFLSLFKFIPKYLQWFFLKDNSAVIKEYLSKFSQ 562
             ||....:|||||.|||..|||..|.:...:||....:|..:|...|:|||||.||||||..|..
 Worm   518 IVTESQHFVYWQGCDSLATPFLLANMSKPHVAFACFKEFTYRYCHKFYLKDNSEVIKEYLGIFYH 582

  Fly   563 LTAFHEPLLAQHLASISFIPELFAIPWFLTMFSHVFPLHKILHLWDKLMLGDSSYPLFIGIAILR 627
            |.|:.:|:|.:||....|..||||||||||.|:|..||.|::.|||:.|:..:::||.|.:|:|.
 Worm   583 LVAYTDPVLYKHLKINGFDAELFAIPWFLTCFAHELPLSKLVLLWDETMMHGNAFPLMIALAMLN 647

  Fly   628 QLRSTLLTSGFNECILLFSDLPDIVMDGCVLESQKMYEATPKSITHRQHALRLQPPQALDI---- 688
            :||..||...|||.|::..|.||:.:|..:..|:...:..|.|.|.|.||...:...|.||
 Worm   648 RLRDKLLAVNFNEMIIIIHDQPDLSIDEIIKNSRGYEKLIPPSCTFRAHASPWKENYAGDIYCLP 712

  Fly   689 -GVADVELKHLQQEQCPRISAKDVQFLLDNSPAELALIDLRSVVEFGRVHVPHSINIPFATVQLG 752
             .:|.:.|:.|....|||:|::::.:.::..  .:.::|.|...||.......|.|.|....:..
 Worm   713 NSMAGLSLQQLSSIHCPRMSSEELIWRIERK--MVYVLDTRQESEFQSERFSDSFNHPNNNHEAD 775

  Fly   753 EQRLEALQVPQLEAQLRGKIVVCVSNIHQHSVEFSHFLVACGVQRTCILHKGFNVLHS 810
            ...|..|  |.:......|..|...|..:.:...:...|..||...|:||..|..:.:
 Worm   776 IDWLRFL--PGIVCSELPKCFVYGKNDKEAAERLTEAYVMKGVPYICLLHDHFEAVRN 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4041	NP_572197.4	Protein Kinases, catalytic domain	48..263	CDD:473864	56/263 (21%)
		TBC	432..634	CDD:214540	94/205 (46%)
		RHOD_Kc	706..810	CDD:238783	21/103 (20%)
tbck-1	NP_001364726.1	Protein Kinases, catalytic domain	<42..238	CDD:473864	49/208 (24%)
		TBC	444..654	CDD:214540	94/209 (45%)