DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32772 and ZKSCAN3

DIOPT Version :9

Sequence 1:	NP_001284870.1	Gene:	CG32772 / 31420	FlyBaseID:	FBgn0052772	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001229823.1	Gene:	ZKSCAN3 / 80317	HGNCID:	13853	Length:	538	Species:	Homo sapiens

Alignment Length:	409	Identity:	109/409 - (26%)
Similarity:	174/409 - (42%)	Gaps:	73/409 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LCFQTATLFQVPGYSIPTCVRCSEQLTNNSNF--------HQSAAAAAAVAASASAAVAASAAAA 63
            ||.:.|.|...||             :.:|.|        |:|..:...........|.|.....
Human   145 LCCKMALLTPAPG-------------SQSSQFQLMKALLKHESVGSQPLQDRVLQVPVLAHGGCC 196

  Fly    64 ATSSSTAS--SSDSDAIAQQQQ---HQNPQQQQHQNSQ------QQQQQQQQMQSSSSSENLQSQ 117
            ......||  :.:|..:.:.:.   ...|:..|..:||      ::|:....:.|....:..:|:
Human   197 REDKVVASRLTPESQGLLKVEDVALTLTPEWTQQDSSQGNLCRDEKQENHGSLVSLGDEKQTKSR 261

  Fly   118 DDSEDVDLIFNEEG--SC---------PLCNKTFSRKSSLMTHIRNHSAERKFVCTYCHKGFTQA 171
            |.....:|...|.|  ||         |.|.:...::..|....:|.:..|:.:|..|.|.|.|:
Human   262 DLPPAEELPEKEHGKISCHLREDIAQIPTCAEAGEQEGRLQRKQKNATGGRRHICHECGKSFAQS 326

  Fly   172 ANLRNHERIHTNDRPYQCVDCGKTFTQITNLNNHRRLHTGERPFVCNEPECGRSFAQVTNLNNHM 236
            :.|..|.||||.::||:|.:|||.|...:.|..|:|:||||:|:.|.  |||::|:..::|..|.
Human   327 SGLSKHRRIHTGEKPYECEECGKAFIGSSALVIHQRVHTGEKPYECE--ECGKAFSHSSDLIKHQ 389

  Fly   237 KSHHKVQQYCCNVCNKKFTQVTSLNQHLQAHAGVTGYYCPRCPEKNFKLQSQLHTHMKTH----- 296
            ::|...:.|.|:.|.|.|:|..||.:|.:.|.|...|.|..| .|.|:..|.|..|.:.|
Human   390 RTHTGEKPYECDDCGKTFSQSCSLLEHHRIHTGEKPYQCSMC-GKAFRRSSHLLRHQRIHTGDKN 453

  Fly   297 ------GLAF---------------PYECDKCDEKFLQQAHLDQHLKMH-DEFKFKCDICPSSFN 339
                  |.|:               .|:|::|:..|.|...|.:|.|:| .|..::|:.|...|.
Human   454 VQEPEQGEAWKSRMESQLENVETPMSYKCNECERSFTQNTGLIEHQKIHTGEKPYQCNACGKGFT 518

  Fly   340 QESLLKKHVQRHVEGRYLS 358
            :.|.|.:|.:.||....||
Human   519 RISYLVQHQRSHVGKNILS 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32772	NP_001284870.1	COG5048	<124..378	CDD:227381	86/273 (32%)
		C2H2 Zn finger	133..153	CDD:275368	4/28 (14%)
		zf-H2C2_2	145..170	CDD:290200	7/24 (29%)
		C2H2 Zn finger	161..181	CDD:275368	8/19 (42%)
		zf-H2C2_2	173..198	CDD:290200	13/24 (54%)
		C2H2 Zn finger	189..209	CDD:275368	8/19 (42%)
		C2H2 Zn finger	217..239	CDD:275368	7/21 (33%)
		zf-H2C2_2	231..256	CDD:290200	8/24 (33%)
		C2H2 Zn finger	247..267	CDD:275368	8/19 (42%)
		C2H2 Zn finger	275..296	CDD:275368	7/20 (35%)
		C2H2 Zn finger	304..324	CDD:275368	7/19 (37%)
		C2H2 Zn finger	331..351	CDD:275368	6/19 (32%)
		C2H2 Zn finger	359..380	CDD:275368	109/409 (27%)
ZKSCAN3	NP_001229823.1	SCAN	42..154	CDD:128708	4/8 (50%)
		SCAN	42..130	CDD:280241
		KRAB	214..274	CDD:214630	9/59 (15%)
		KRAB	217..252	CDD:279668	5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..274		8/47 (17%)
		zf-C2H2	314..336	CDD:278523	8/21 (38%)
		C2H2 Zn finger	316..336	CDD:275368	8/19 (42%)
		zf-H2C2_2	329..351	CDD:290200	12/21 (57%)
		C2H2 Zn finger	344..364	CDD:275368	8/19 (42%)
		zf-H2C2_2	356..381	CDD:290200	13/26 (50%)
		COG5048	<368..515	CDD:227381	43/149 (29%)
		C2H2 Zn finger	372..392	CDD:275368	7/21 (33%)
		zf-H2C2_2	384..409	CDD:290200	8/24 (33%)
		C2H2 Zn finger	400..420	CDD:275368	8/19 (42%)
		zf-H2C2_2	412..437	CDD:290200	10/25 (40%)
		C2H2 Zn finger	428..448	CDD:275368	7/20 (35%)
		zf-C2H2	480..502	CDD:278523	8/21 (38%)
		C2H2 Zn finger	482..502	CDD:275368	7/19 (37%)
		zf-H2C2_2	495..519	CDD:290200	8/23 (35%)
		C2H2 Zn finger	510..530	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100