DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32772 and Prdm5

DIOPT Version :9

Sequence 1:	NP_001284870.1	Gene:	CG32772 / 31420	FlyBaseID:	FBgn0052772	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_006506667.1	Gene:	Prdm5 / 70779	MGIID:	1918029	Length:	630	Species:	Mus musculus

Alignment Length:	412	Identity:	102/412 - (24%)
Similarity:	170/412 - (41%)	Gaps:	76/412 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 CVRCSEQLTNNSNFHQSAAAAAAVAASASAAVAASAAAAATSSSTASSSDSDAIAQQQQH---QN 86
            |..|:...::..:|.|...|....|.....|          .|........||:.:.|::   .:
Mouse   236 CALCNSLFSSALSFEQHRKACRGEARFVCKA----------DSCGKRLKSKDALRRHQENVHTGD 290

  Fly    87 PQQ-----------------QQHQNSQQQQQQQQQMQSSSSSENLQSQDDSEDVDLIFNEEG--- 131
            |::                 |:|:...:....|:.|:...|:..|:..       :|.:.|.
Mouse   291 PKRKLICSVCNRKCTSVSSLQEHRKIHEIFDCQECMKKFISANQLKRH-------MITHSEKRPY 348

  Fly   132 SCPLCNKTFSRKSSLMTHIRNHSAERKFVCTYCHKGFTQAANLRNHERIHTNDRPYQCVDCGKTF 196
            :|.:|||:|.|...:..|...||.::.:.|..|.|||......:||::.|:.:||:||..|...|
Mouse   349 NCEICNKSFKRLDQVGAHKVIHSEDKPYQCKLCGKGFAHRNVYKNHKKTHSEERPFQCDACKALF 413

  Fly   197 TQITNLNNHRRLHTGERPFVCNEPE---------------------------CGRSFAQVTNLNN 234
            ....:|..|..:|..||.|.|:..:                           |.::|...:.|.:
Mouse   414 RTPFSLQRHLLIHNSERTFKCHHCDATFKRKDTLNVHVQVVHERHKKYRCELCNKAFVTPSVLRS 478

  Fly   235 HMKSHHKVQQYCCNVCNKKFTQVTSLNQHLQAHAGVTGYYCPRCPEKNFKLQSQLHTHMKTHGLA 299
            |.|:|...::..|..|.:||....:|..|:::|.|...|.||.| ||.|.....|..|::||...
Mouse   479 HKKTHTGEKEKVCPYCGQKFASSGTLRVHIRSHTGERPYQCPYC-EKGFSKNDGLKMHIRTHTRE 542

  Fly   300 FPYECDKCDEKFLQQAHLDQHLKMH-DEFKFKCDICPSSFNQESLLKKHVQRHVEGRYLSCPVAN 363
            .||:|.:|.:.|.|:..||:|.:.| .|..|:||:|..:|:.:.:|.:|...|...|    |:|.
Mouse   543 KPYQCSECSKAFSQKRGLDEHKRTHTGEKPFQCDVCDLAFSLKKMLIRHKMTHNPNR----PMAE 603

  Fly   364 ---CAESFAVRQHLSKHLLTNH 382
               |.:.|....:|..|:...|
Mouse   604 CHFCHKKFTRNDYLKVHMDNIH 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32772	NP_001284870.1	COG5048	<124..378	CDD:227381	82/287 (29%)
		C2H2 Zn finger	133..153	CDD:275368	7/19 (37%)
		zf-H2C2_2	145..170	CDD:290200	8/24 (33%)
		C2H2 Zn finger	161..181	CDD:275368	7/19 (37%)
		zf-H2C2_2	173..198	CDD:290200	9/24 (38%)
		C2H2 Zn finger	189..209	CDD:275368	5/19 (26%)
		C2H2 Zn finger	217..239	CDD:275368	6/48 (13%)
		zf-H2C2_2	231..256	CDD:290200	8/24 (33%)
		C2H2 Zn finger	247..267	CDD:275368	6/19 (32%)
		C2H2 Zn finger	275..296	CDD:275368	8/20 (40%)
		C2H2 Zn finger	304..324	CDD:275368	7/19 (37%)
		C2H2 Zn finger	331..351	CDD:275368	6/19 (32%)
		C2H2 Zn finger	359..380	CDD:275368	6/23 (26%)
Prdm5	XP_006506667.1	PR-SET_PRDM5	2..128	CDD:380967
		C2H2 Zn finger	169..190	CDD:275368
		zf-C2H2_8	<172..222	CDD:374215
		C2H2 Zn finger	201..217	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368	4/19 (21%)
		COG5048	258..621	CDD:227381	95/384 (25%)
		C2H2 Zn finger	264..287	CDD:275368	5/32 (16%)
		C2H2 Zn finger	297..317	CDD:275368	2/19 (11%)
		C2H2 Zn finger	322..342	CDD:275368	5/26 (19%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		C2H2 Zn finger	406..426	CDD:275368	5/19 (26%)
		C2H2 Zn finger	434..455	CDD:275368	1/20 (5%)
		C2H2 Zn finger	463..483	CDD:275368	5/19 (26%)
		C2H2 Zn finger	491..511	CDD:275368	6/19 (32%)
		C2H2 Zn finger	519..539	CDD:275368	8/20 (40%)
		C2H2 Zn finger	547..567	CDD:275368	7/19 (37%)
		C2H2 Zn finger	575..595	CDD:275368	6/19 (32%)
		C2H2 Zn finger	604..625	CDD:275368	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100