DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32772 and ZSCAN18

DIOPT Version :9

Sequence 1:	NP_001284870.1	Gene:	CG32772 / 31420	FlyBaseID:	FBgn0052772	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001139014.1	Gene:	ZSCAN18 / 65982	HGNCID:	21037	Length:	566	Species:	Homo sapiens

Alignment Length:	270	Identity:	52/270 - (19%)
Similarity:	82/270 - (30%)	Gaps:	89/270 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 SASAAVAASAAAAATSSSTASSSDSDAIA----------QQQQHQNPQQQQHQNSQQQQQQQQQM 105
            ||..|...:|.|.........:...||:|          ::|..:.|..|..|:::.......|.
Human   343 SAGCACEEAAPAGVLPELPTEAPPGDALADPPSGTTEEEEEQPGKAPDPQDPQDAESDSATGSQR 407

  Fly   106 QS-------------------------SSSSENLQSQDDSEDVDLIFNEEGSCPLCNKTFSRKSS 145
            ||                         ..|.|.:.|..||..:     |.|..|..::
Human   408 QSVIQQPAPDRGTAKLGTKRPHPEDGDGQSLEGVSSSGDSAGL-----EAGQGPGADE------- 460

  Fly   146 LMTHIRNHSAERKFVCTYCHKGFTQAANLRNHERIHTNDRPYQCVDCGKTFTQITNLNNHRRLHT 210
                                .|.::.             :||.|.:||:.|..:::|..|...|.
Human   461 --------------------PGLSRG-------------KPYACGECGEAFAWLSHLMEHHSSHG 492

  Fly   211 GERPFVCNEPECGRSFAQVTNLNNHMKSHHKVQQYCCNVCNKKFTQVTSLNQHLQAHAG-----V 270
            |.:.:.|.  .|.::|.....|..|.|:|.|.:.|...  ..:..|.::......|.||     |
Human   493 GRKRYACQ--GCWKTFHFSLALAEHQKTHEKEKSYALG--GARGPQPSTREAQAGARAGGPPESV 553

  Fly   271 TGYYCPRCPE 280
            .|...|..||
Human   554 EGEAPPAPPE 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32772	NP_001284870.1	COG5048	<124..378	CDD:227381	32/162 (20%)
		C2H2 Zn finger	133..153	CDD:275368	1/19 (5%)
		zf-H2C2_2	145..170	CDD:290200	1/24 (4%)
		C2H2 Zn finger	161..181	CDD:275368	1/19 (5%)
		zf-H2C2_2	173..198	CDD:290200	6/24 (25%)
		C2H2 Zn finger	189..209	CDD:275368	6/19 (32%)
		C2H2 Zn finger	217..239	CDD:275368	6/21 (29%)
		zf-H2C2_2	231..256	CDD:290200	6/24 (25%)
		C2H2 Zn finger	247..267	CDD:275368	1/19 (5%)
		C2H2 Zn finger	275..296	CDD:275368	3/6 (50%)
		C2H2 Zn finger	304..324	CDD:275368
		C2H2 Zn finger	331..351	CDD:275368
		C2H2 Zn finger	359..380	CDD:275368
ZSCAN18	NP_001139014.1	SCAN	102..189	CDD:280241
		KRAB	<284..321	CDD:214630
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
		C2H2 Zn finger	499..519	CDD:275368	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100