DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32772 and MYNN

DIOPT Version :9

Sequence 1:	NP_001284870.1	Gene:	CG32772 / 31420	FlyBaseID:	FBgn0052772	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001172047.1	Gene:	MYNN / 55892	HGNCID:	14955	Length:	610	Species:	Homo sapiens

Alignment Length:	398	Identity:	112/398 - (28%)
Similarity:	178/398 - (44%)	Gaps:	41/398 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 AQQQQHQNPQQQQHQNSQQQQQQQQQMQSSSSS--ENLQSQDDSEDVDLIFNE-EGSCPLCNKTF 140
            ||...|....:::...||.....::...|:.:|  ...::::..|::|..::: :..|..|.|.|
Human   247 AQDIVHTVTVKRKRGKSQPNCALKEHSMSNIASVKSPYEAENSGEELDQRYSKAKPMCNTCGKVF 311

  Fly   141 SRKSSLMTHIRNHSAERKFVCTYCHKGFTQAANLRNHERIHTNDRPYQCVDCGKTFTQITNLNNH 205
            |..|||..|:|.|...:.:||..|.|.|||...|:.|.|.||.::||:|..|.|.|.|...|..|
Human   312 SEASSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHVRTHTGEKPYKCELCDKGFAQKCQLVFH 376

  Fly   206 RRLHTG-ERPFVCNEPECGRSFAQVTNLNNHMKSHHKVQQYCCNVCNKKFTQVTSLNQHLQAHAG 269
            .|:|.| |:|:.|:  .|...||..:||..|.:.|...:.|.|:.|.::|.|.::|..|::.|.|
Human   377 SRMHHGEEKPYKCD--VCNLQFATSSNLKIHARKHSGEKPYVCDRCGQRFAQASTLTYHVRRHTG 439

  Fly   270 VTGYYCPRCPEKNFKLQSQLHTHMKTHGLAFPYECDKCDEKFLQQAHLDQHLKMH-DEFKFKCDI 333
            ...|.|..| .|.|.:.|.|.||.:.|....||.|..|.:.|:....|::|.:.| .|..|.|::
Human   440 EKPYVCDTC-GKAFAVSSSLITHSRKHTGEKPYICGICGKSFISSGELNKHFRSHTGERPFICEL 503

  Fly   334 CPSSFNQESLLKKHVQRHVEGRYLSCPVANCAESFAVRQHLSKHLLTNHAHHELPPPKRSKKAGT 398
            |.:|:.....||||..:                   |.....|.|.::...|.|......:|:..
Human   504 CGNSYTDIKNLKKHKTK-------------------VHSGADKTLDSSAEDHTLSEQDSIQKSPL 549

  Fly   399 LQTSQQPLAMIGQPLSLQHTTGQRGRPPKNKNKATTLAATAIKIEINESLHSQHISNVSGLSIQQ 463
            .:|.....:.:..||:|         |...::....|..|..:...:::|..   |.|:|.|..|
Human   550 SETMDVKPSDMTLPLAL---------PLGTEDHHMLLPVTDTQSPTSDTLLR---STVNGYSEPQ 602

  Fly   464 QINQHMQQ 471
            .|  .:||
Human   603 LI--FLQQ 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32772	NP_001284870.1	COG5048	<124..378	CDD:227381	84/256 (33%)
		C2H2 Zn finger	133..153	CDD:275368	10/19 (53%)
		zf-H2C2_2	145..170	CDD:290200	10/24 (42%)
		C2H2 Zn finger	161..181	CDD:275368	9/19 (47%)
		zf-H2C2_2	173..198	CDD:290200	11/24 (46%)
		C2H2 Zn finger	189..209	CDD:275368	8/19 (42%)
		C2H2 Zn finger	217..239	CDD:275368	7/21 (33%)
		zf-H2C2_2	231..256	CDD:290200	8/24 (33%)
		C2H2 Zn finger	247..267	CDD:275368	6/19 (32%)
		C2H2 Zn finger	275..296	CDD:275368	8/20 (40%)
		C2H2 Zn finger	304..324	CDD:275368	5/19 (26%)
		C2H2 Zn finger	331..351	CDD:275368	7/19 (37%)
		C2H2 Zn finger	359..380	CDD:275368	3/20 (15%)
MYNN	NP_001172047.1	BTB	14..115	CDD:306997
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..197
		Nuclear localization signal. /evidence=ECO:0000255	174..190
		Nuclear localization signal. /evidence=ECO:0000255	257..262		0/4 (0%)
		C2H2 Zn finger	304..324	CDD:275368	10/19 (53%)
		zf-C2H2	304..324	CDD:306579	10/19 (53%)
		zf-H2C2_2	316..341	CDD:316026	10/24 (42%)
		C2H2 Zn finger	332..352	CDD:275368	9/19 (47%)
		zf-H2C2_2	345..369	CDD:316026	11/23 (48%)
		SFP1	<354..438	CDD:227516	29/85 (34%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	389..409	CDD:275368	7/21 (33%)
		C2H2 Zn finger	417..437	CDD:275368	6/19 (32%)
		zf-H2C2_2	430..453	CDD:316026	8/23 (35%)
		SFP1	<439..522	CDD:227516	28/102 (27%)
		C2H2 Zn finger	445..465	CDD:275368	8/20 (40%)
		C2H2 Zn finger	473..493	CDD:275368	5/19 (26%)
		C2H2 Zn finger	501..522	CDD:275368	7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..556		7/34 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100