DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32772 and ZSCAN32

DIOPT Version :9

Sequence 1:	NP_001284870.1	Gene:	CG32772 / 31420	FlyBaseID:	FBgn0052772	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001271456.1	Gene:	ZSCAN32 / 54925	HGNCID:	20812	Length:	697	Species:	Homo sapiens

Alignment Length:	259	Identity:	79/259 - (30%)
Similarity:	120/259 - (46%)	Gaps:	39/259 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 DSDAIAQQQQHQNPQQQQHQNSQQQQQQQQQM--QSSSSSENLQSQDDSEDVD------LIFNEE 130
            :|:..:::|...:|.:.:.:...|::...|..  :..:.:..|..::.|:.|.      |...:.
Human   456 ESEPTSRRQCRNSPGESEEKTPSQEKMSHQSFCARDKACTHILCGKNCSQSVHSPHKPALKLEKV 520

  Fly   131 GSCPLCNKTFSRKSSLMTHIRNHSAERKFVCTYCHKGFTQAANLRNHERIHTNDRPYQCVDCGKT 195
            ..||.|.|||||.|.|:.|.|.|:.|:...|:.|.|||::.:||..|.|.||.:|||||..|||:
Human   521 SQCPECGKTFSRSSYLVRHQRIHTGEKPHKCSECGKGFSERSNLTAHLRTHTGERPYQCGQCGKS 585

  Fly   196 FTQITNLNNHRRLHTGERPFVCNEPECGRSFAQVTNLNNHMKSHHKVQQYCCNVCNKKFTQVTSL 260
            |.|.::|..|:|.||||:|                              |.|.||.|:|...:..
Human   586 FNQSSSLIVHQRTHTGEKP------------------------------YQCIVCGKRFNNSSQF 620

  Fly   261 NQHLQAHAGVTGYYCPRCPEKNFKLQSQLHTHMKTHGLAFPYECDKCDEKFLQQAHLDQHLKMH 324
            :.|.:.|.|.:.|.|..| .|.|...|....|.|||....||.|..|:..|.:.:.|.:|..:|
Human   621 SAHRRIHTGESPYKCAVC-GKIFNNSSHFSAHRKTHTGEKPYRCSHCERGFTKNSALTRHQTVH 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32772	NP_001284870.1	COG5048	<124..378	CDD:227381	71/207 (34%)
		C2H2 Zn finger	133..153	CDD:275368	12/19 (63%)
		zf-H2C2_2	145..170	CDD:290200	10/24 (42%)
		C2H2 Zn finger	161..181	CDD:275368	9/19 (47%)
		zf-H2C2_2	173..198	CDD:290200	15/24 (63%)
		C2H2 Zn finger	189..209	CDD:275368	9/19 (47%)
		C2H2 Zn finger	217..239	CDD:275368	0/21 (0%)
		zf-H2C2_2	231..256	CDD:290200	6/24 (25%)
		C2H2 Zn finger	247..267	CDD:275368	6/19 (32%)
		C2H2 Zn finger	275..296	CDD:275368	7/20 (35%)
		C2H2 Zn finger	304..324	CDD:275368	5/19 (26%)
		C2H2 Zn finger	331..351	CDD:275368
		C2H2 Zn finger	359..380	CDD:275368
ZSCAN32	NP_001271456.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		SCAN	33..142	CDD:128708
		SCAN	33..121	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..177
		KRAB_A-box	218..250	CDD:295379
		Myb_DNA-bind_4	253..334	CDD:290549
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..395
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..482		4/25 (16%)
		COG5048	<455..668	CDD:227381	75/242 (31%)
		zf-C2H2	522..543	CDD:278523	12/20 (60%)
		C2H2 Zn finger	523..543	CDD:275368	12/19 (63%)
		zf-H2C2_2	535..559	CDD:290200	9/23 (39%)
		C2H2 Zn finger	551..571	CDD:275368	9/19 (47%)
		zf-H2C2_2	563..588	CDD:290200	15/24 (63%)
		C2H2 Zn finger	579..599	CDD:275368	9/19 (47%)
		zf-H2C2_2	591..616	CDD:290200	14/54 (26%)
		C2H2 Zn finger	607..627	CDD:275368	6/19 (32%)
		zf-H2C2_2	623..644	CDD:290200	8/21 (38%)
		C2H2 Zn finger	635..655	CDD:275368	7/20 (35%)
		zf-H2C2_2	647..671	CDD:290200	8/23 (35%)
		zf-C2H2	661..683	CDD:278523	6/21 (29%)
		C2H2 Zn finger	663..683	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100