DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32772 and ZKSCAN4

DIOPT Version :9

Sequence 1:	NP_001284870.1	Gene:	CG32772 / 31420	FlyBaseID:	FBgn0052772	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_061983.2	Gene:	ZKSCAN4 / 387032	HGNCID:	13854	Length:	545	Species:	Homo sapiens

Alignment Length:	408	Identity:	107/408 - (26%)
Similarity:	163/408 - (39%)	Gaps:	71/408 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LCFQTATLFQVPGYSIPTC----VRCSEQLTNNSNFHQSAAAAAAVAASASAAVAASAAAAATSS 67
            ||.:.|.|.|..|.....|    .....:...:...|........:|........|..|:..|..
Human   152 LCCKMALLTQTQGSQSSQCQPMKALFKHESLGSQPLHDRVLQVPGLAQGGCCREDAMVASRLTPG 216

  Fly    68 STASSSDSDAIAQQQQHQNPQQQQHQNSQQQQQQQQQMQSSSSSENLQSQDDSEDVDLIFNEEGS 132
            |.......|....    ..|...|..:||....:.::.::.||..:|..:..::..||
Human   217 SQGLLKMEDVALT----LTPGWTQLDSSQVNLYRDEKQENHSSLVSLGGEIQTKSRDL------- 270

  Fly   133 CPLCNKTFSRKSSLMTHIRNHSAE------------------------RKFVCTYCHKGFTQAAN 173
             |...|...::...:.|:|...|:                        |:..|..|.|.|.|::.
Human   271 -PPVKKLPEKEHGKICHLREDIAQIPTHAEAGEQEGRLQRKQKNAIGSRRHYCHECGKSFAQSSG 334

  Fly   174 LRNHERIHTNDRPYQCVDCGKTFTQITNLNNHRRLHTGERPFVCNEPECGRSFAQVTNLNNHMKS 238
            |..|.||||.::||:|.||||||...:.|..|:|:||||:|:.|.  |||:.|:..:||..|.::
Human   335 LTKHRRIHTGEKPYECEDCGKTFIGSSALVIHQRVHTGEKPYECE--ECGKVFSHSSNLIKHQRT 397

  Fly   239 HHKVQQYCCNVCNKKFTQVTSLNQHLQAHAGVTGYYCPRCPEKNFKLQSQLHTHMKTHG------ 297
            |...:.|.|:.|.|.|:|..||.:|.:.|.|...|.|..| .|.|:..|.|..|.:.||
Human   398 HTGEKPYECDDCGKTFSQSCSLLEHHKIHTGEKPYQCNMC-GKAFRRNSHLLRHQRIHGDKNVQN 461

  Fly   298 ---------------------LAFPYECDKCDEKFLQQAHLDQHLKMH-DEFKFKCDICPSSFNQ 340
                                 ....|:|::|:..|.:...|.:|.|:| .|..::||.|...|.:
Human   462 PEHGESWESQGRTESQWENTEAPVSYKCNECERSFTRNRSLIEHQKIHTGEKPYQCDTCGKGFTR 526

  Fly   341 ESLLKKHVQRHVEGRYLS 358
            .|.|.:|.:.||..:.||
Human   527 TSYLVQHQRSHVGKKTLS 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32772	NP_001284870.1	COG5048	<124..378	CDD:227381	86/287 (30%)
		C2H2 Zn finger	133..153	CDD:275368	4/19 (21%)
		zf-H2C2_2	145..170	CDD:290200	8/48 (17%)
		C2H2 Zn finger	161..181	CDD:275368	8/19 (42%)
		zf-H2C2_2	173..198	CDD:290200	15/24 (63%)
		C2H2 Zn finger	189..209	CDD:275368	10/19 (53%)
		C2H2 Zn finger	217..239	CDD:275368	8/21 (38%)
		zf-H2C2_2	231..256	CDD:290200	9/24 (38%)
		C2H2 Zn finger	247..267	CDD:275368	8/19 (42%)
		C2H2 Zn finger	275..296	CDD:275368	7/20 (35%)
		C2H2 Zn finger	304..324	CDD:275368	6/19 (32%)
		C2H2 Zn finger	331..351	CDD:275368	7/19 (37%)
		C2H2 Zn finger	359..380	CDD:275368	107/408 (26%)
ZKSCAN4	NP_061983.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..55
		SCAN	49..160	CDD:128708	3/7 (43%)
		KRAB	221..281	CDD:214630	12/71 (17%)
		zf-C2H2	320..342	CDD:306579	8/21 (38%)
		C2H2 Zn finger	322..342	CDD:275368	8/19 (42%)
		zf-H2C2_2	335..357	CDD:316026	13/21 (62%)
		C2H2 Zn finger	350..370	CDD:275368	10/19 (53%)
		COG5048	<374..544	CDD:227381	49/172 (28%)
		C2H2 Zn finger	378..398	CDD:275368	8/21 (38%)
		C2H2 Zn finger	406..426	CDD:275368	8/19 (42%)
		C2H2 Zn finger	434..454	CDD:275368	7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..480		1/24 (4%)
		C2H2 Zn finger	489..509	CDD:275368	6/19 (32%)
		C2H2 Zn finger	517..537	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100