DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32772 and Zfp523

DIOPT Version :9

Sequence 1:	NP_001284870.1	Gene:	CG32772 / 31420	FlyBaseID:	FBgn0052772	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001128227.1	Gene:	Zfp523 / 361809	RGDID:	1306239	Length:	568	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	127/556 - (22%)
Similarity:	203/556 - (36%)	Gaps:	162/556 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TNNSNFHQSAAAAAAVAASASAAVAASAAAAATSSSTASSSD---SDAIAQQQQ----------- 83
            |....:..||..|..:...::|.:....:....|:..|..::   .|..|::::
  Rat    75 TPKEGYDPSALEAVQLEDGSTAYIHHPVSVPPDSTILAVQTEVGLEDLAAEEEEGFGADTVVALE 139

  Fly    84 -------HQNPQQQQHQNSQQQQQQQQQMQSS--------SSSENLQSQDDSEDVDLIFNEEGSC 133
                   |.:|..   .|.:.||...:..:..        :::.:|:..:.:...|..:.    |
  Rat   140 QYASKVLHDSPAS---HNGKGQQVGDRAFRCGYKGCGRLYTTAHHLKVHERAHTGDRSYR----C 197

  Fly   134 --PLCNKTFSRKSSLMTHIRNHSAERKFVC--TYCHKGFTQAANLRNHERIHTNDRPYQC--VDC 192
              |.|.|.|:....|.:|:|.|:.|:.:.|  ..|.|.|..:.:|:.|.|.||.:||::|  ..|
  Rat   198 DFPSCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAFKTSGDLQKHVRTHTGERPFRCPFEGC 262

  Fly   193 GKTFTQITNLNNHRRLHTGERPFVCNEPECGRSFAQVTNLNNHMKSHHKVQQYCCNV--CNKKFT 255
            |::||.......|.|.||||||:.|.||.|||.|...||..||::.|...:.|.|.|  |.|:||
  Rat   263 GRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFT 327

  Fly   256 QVTSLNQHLQAHAGVTGYYCPRCPEKNFKLQSQLHTHMKTHGLAFPYECDKCDEKFLQQAHLDQH 320
            :.:||.:|   |.                    :|||.|      ||.|..|.:.:.|.:.|..|
  Rat   328 EYSSLYKH---HV--------------------VHTHCK------PYTCSSCGKTYRQTSTLAMH 363

  Fly   321 LK-MHDEFKFKCDICPSSFNQESLLKKHVQRHVEGRYLSCPVANCAESFAVRQHLSKHLLTNHAH 384
            .: .|.|.:         ..:||....:.|:.:|       .|:.||
  Rat   364 KRSAHGELE---------ATEESEQALYEQQQLE-------AASAAE------------------ 394

  Fly   385 HELPPPKRSKKA----------------------------------GTLQTSQQP--LAMIGQPL 413
             |.|.||.:..|                                  ||.|.|..|  |..:|..:
  Rat   395 -ESPSPKPTHIAYLSEVKEESSDIPTQVAMVTEEDGAPQVALITQDGTQQVSLSPEDLQALGSAI 458

  Fly   414 SL--QHTTGQRGRPPKNKNKATTLAATAIKIEINESLHSQHISNV-SGLSIQQQ---INQHMQQQ 472
            |:  ||.:.....|...:..||:...|...:.. :...:|.::.: ||..:.:.   .:.|.||.
  Rat   459 SVVTQHRSTTLTIPGHQEELATSGTHTVTMVSA-DGTQTQPVTIITSGALVTEDSSVASLHHQQV 522

  Fly   473 A----------AQQQAQQQAAQQQQQQAAQQQQQAA 498
            |          |.|...||..::....|....||.|
  Rat   523 ALLATANGTHIAVQLEDQQTLEEVISVATSAMQQGA 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32772	NP_001284870.1	COG5048	<124..378	CDD:227381	78/262 (30%)
		C2H2 Zn finger	133..153	CDD:275368	8/21 (38%)
		zf-H2C2_2	145..170	CDD:290200	9/26 (35%)
		C2H2 Zn finger	161..181	CDD:275368	7/21 (33%)
		zf-H2C2_2	173..198	CDD:290200	11/26 (42%)
		C2H2 Zn finger	189..209	CDD:275368	7/21 (33%)
		C2H2 Zn finger	217..239	CDD:275368	11/21 (52%)
		zf-H2C2_2	231..256	CDD:290200	10/26 (38%)
		C2H2 Zn finger	247..267	CDD:275368	9/21 (43%)
		C2H2 Zn finger	275..296	CDD:275368	4/20 (20%)
		C2H2 Zn finger	304..324	CDD:275368	5/20 (25%)
		C2H2 Zn finger	331..351	CDD:275368	3/19 (16%)
		C2H2 Zn finger	359..380	CDD:275368	3/20 (15%)
Zfp523	NP_001128227.1	3 X 12 AA approximate repeats	34..99		5/23 (22%)
		C2H2 Zn finger	167..189	CDD:275368	1/21 (5%)
		zf-H2C2_2	181..208	CDD:290200	7/30 (23%)
		COG5048	192..>257	CDD:227381	22/68 (32%)
		C2H2 Zn finger	197..219	CDD:275368	8/21 (38%)
		zf-H2C2_2	212..238	CDD:290200	9/25 (36%)
		zf-C2H2_aberr	225..346	CDD:293622	52/149 (35%)
		C2H2 Zn finger	227..249	CDD:275368	7/21 (33%)
		zf-H2C2_2	241..268	CDD:290200	11/26 (42%)
		C2H2 Zn finger	257..279	CDD:275368	7/21 (33%)
		zf-H2C2_2	273..298	CDD:290200	15/24 (63%)
		C2H2 Zn finger	287..309	CDD:275368	11/21 (52%)
		zf-H2C2_2	301..327	CDD:290200	9/25 (36%)
		C2H2 Zn finger	317..339	CDD:275368	10/44 (23%)
		C2H2 Zn finger	347..365	CDD:275368	5/17 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..401		12/70 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100