DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32772 and ZBTB41

DIOPT Version :9

Sequence 1:	NP_001284870.1	Gene:	CG32772 / 31420	FlyBaseID:	FBgn0052772	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_919290.2	Gene:	ZBTB41 / 360023	HGNCID:	24819	Length:	909	Species:	Homo sapiens

Alignment Length:	588	Identity:	120/588 - (20%)
Similarity:	203/588 - (34%)	Gaps:	204/588 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 TSSSTASSSD-SDAIAQQQQHQNPQQQQHQNSQ--------QQQQQQQQMQSSSSSENLQSQDDS 120
            ||.....|.| ||.:  .|::.:.::....:|:        ::.:.:::|....|....||:.|.
Human   266 TSDDEQESGDGSDNL--NQENFDKEKSDRNDSEDPGSEYNAEEDELEEEMSDEYSDIEEQSEKDH 328

  Fly   121 EDV-------DLIFN-EEG--------------SCPLCNKTFSRKSSLMTHIRNHSAERKFVCTY 163
            .|.       |.:.| .||              .||.|:|||.|.....:|.|.|:.|:.|.|..
Human   329 NDAEEEPEAGDSVGNVHEGLTPVVIQNSNKKILQCPKCDKTFDRIGKYESHTRVHTGEKPFECDI 393

  Fly   164 CHKGFTQAANLRNHERIHTNDR---------PY-------------------------------- 187
            ||:.::..:||..|.:.|:|:.         ||
Human   394 CHQRYSTKSNLTVHRKKHSNETEFHKKEHKCPYCNKLHASKKTLAKHVKRFHPENAQEFISIKKT 458

  Fly   188 -----QCVDCGKTFTQITNLNNHRRLHTGERPFVCNEPE-------------------------C 222
                 :|..|.|:||:..:|..|..||:.::||.|...|                         |
Human   459 KSESWKCDICKKSFTRRPHLEEHMILHSQDKPFKCTYCEEHFKSRFARLKHQEKFHLGPFPCDIC 523

  Fly   223 GRSFAQVTNLNNHMK-SHHKVQQYCCNVCNKKFTQVTSLNQHLQAHAGVTGYYCPRCPEKNFKLQ 286
            ||.|....||..|:: :|...:::.|.:|.|...:.|:|.:||:.|:|...:.|..|.: :|:..
Human   524 GRQFNDTGNLKRHIECTHGGKRKWTCFICGKSVRERTTLKEHLRIHSGEKPHLCSICGQ-SFRHG 587

  Fly   287 SQLHTHMKTHGLAFPYECDKCDEKFLQQAHLDQHLKMHDEFK----------------------- 328
            |....|::.|.....||||:|.:.|::..||.:|.|:|...|
Human   588 SSYRLHLRVHHDDKRYECDECGKTFIRHDHLTKHKKIHSGEKAHQCEECGKCFGRRDHLTVHYKS 652

  Fly   329 ---------------FKCDICPSSFNQESLLKKHVQRHVEGRYLSCPVANCAESFAVRQHLSKHL 378
                           .:||:|...|..:|.|:.|.:.|...:...|.:  |.:||.:::.|:|||
Human   653 VHLGEKVWQKYKATFHQCDVCKKIFKGKSSLEMHFRTHSGEKPYKCQI--CNQSFRIKKTLTKHL 715

  Fly   379 LTNHAHHELPPPKRSKKAGTLQTSQQPLAMIGQPLSLQHTTGQRGRPPKNKNKATTLAATAIKIE 443
            :   .|.:                       .:|.:.||......|..|.|
Human   716 V---IHSD-----------------------ARPFNCQHCNATFKRKDKLK-------------- 740

  Fly   444 INESLHSQHISNVS--------------GLSIQQQINQHMQQQAAQQQAQQQAAQQQQQQAAQQQ 494
                .|..|:..:.              .|.::...:..:.|...:|...|....|.:.:...|.
Human   741 ----YHIDHVHEIKSPDDPLSTSEEKLVSLPVEYSSDDKIFQTETKQYMDQPKVYQSEAKTMLQN 801

  Fly   495 QQA 497
            ..|
Human   802 VSA 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32772	NP_001284870.1	COG5048	<124..378	CDD:227381	88/378 (23%)
		C2H2 Zn finger	133..153	CDD:275368	9/19 (47%)
		zf-H2C2_2	145..170	CDD:290200	8/24 (33%)
		C2H2 Zn finger	161..181	CDD:275368	6/19 (32%)
		zf-H2C2_2	173..198	CDD:290200	11/70 (16%)
		C2H2 Zn finger	189..209	CDD:275368	7/19 (37%)
		C2H2 Zn finger	217..239	CDD:275368	9/47 (19%)
		zf-H2C2_2	231..256	CDD:290200	7/25 (28%)
		C2H2 Zn finger	247..267	CDD:275368	7/19 (37%)
		C2H2 Zn finger	275..296	CDD:275368	5/20 (25%)
		C2H2 Zn finger	304..324	CDD:275368	8/19 (42%)
		C2H2 Zn finger	331..351	CDD:275368	7/19 (37%)
		C2H2 Zn finger	359..380	CDD:275368	8/20 (40%)
ZBTB41	NP_919290.2	BTB_POZ_ZBTB41	66..179	CDD:349535
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..344		15/79 (19%)
		C2H2 Zn finger	363..383	CDD:275368	9/19 (47%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	424..442	CDD:275368	2/17 (12%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		C2H2 Zn finger	493..510	CDD:275368	2/16 (13%)
		C2H2 Zn finger	520..541	CDD:275368	7/20 (35%)
		C2H2 Zn finger	549..569	CDD:275368	7/19 (37%)
		C2H2 Zn finger	577..597	CDD:275368	5/20 (25%)
		zf-C2H2	603..625	CDD:395048	10/21 (48%)
		C2H2 Zn finger	605..625	CDD:275368	8/19 (42%)
		C2H2 Zn finger	633..651	CDD:275368	0/17 (0%)
		C2H2 Zn finger	670..687	CDD:275368	6/16 (38%)
		C2H2 Zn finger	698..718	CDD:275368	8/24 (33%)
		C2H2 Zn finger	726..743	CDD:275368	5/34 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010