DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32772 and ZNF621

DIOPT Version :9

Sequence 1:	NP_001284870.1	Gene:	CG32772 / 31420	FlyBaseID:	FBgn0052772	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001091884.1	Gene:	ZNF621 / 285268	HGNCID:	24787	Length:	439	Species:	Homo sapiens

Alignment Length:	192	Identity:	64/192 - (33%)
Similarity:	90/192 - (46%)	Gaps:	3/192 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 CPLCNKTFSRKSSLMTHIRNHSAERKFVCTYCHKGFTQAANLRNHERIHTNDRPYQCVDCGKTFT 197
            |..|.|.|...|.|:.|..:|:.|:.|.|..|.|.|..:.:...||:.|..:.||:|.:|||..:
Human   153 CKECGKIFRYNSKLIRHQMSHTGEKPFKCKECGKAFKSSYDCIVHEKNHIGEGPYECKECGKGLS 217

  Fly   198 QITNLNNHRRLHTGERPFVCNEPECGRSFAQVTNLNNHMKSHHKVQQYCCNVCNKKFTQVTSLNQ 262
            ..|.|..|:|:||||:|:.|.  |||::|.:......|.:.|...:.|.|..|.|.|...:....
Human   218 SNTALTQHQRIHTGEKPYECK--ECGKAFRRSAAYLQHQRLHTGEKLYKCKECWKAFGCRSLFIV 280

  Fly   263 HLQAHAGVTGYYCPRCPEKNFKLQSQLHTHMKTHGLAFPYECDKCDEKFLQQAHLDQHLKMH 324
            |.:.|.|...|.|..| .|.|..:.....|.:.|....||||..|.:.|.......||.|:|
Human   281 HQRIHTGEKPYQCKEC-GKAFTQKIASIQHQRVHTGEKPYECKVCGKAFKWYGSFVQHQKLH 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32772	NP_001284870.1	COG5048	<124..378	CDD:227381	64/192 (33%)
		C2H2 Zn finger	133..153	CDD:275368	7/19 (37%)
		zf-H2C2_2	145..170	CDD:290200	9/24 (38%)
		C2H2 Zn finger	161..181	CDD:275368	6/19 (32%)
		zf-H2C2_2	173..198	CDD:290200	9/24 (38%)
		C2H2 Zn finger	189..209	CDD:275368	8/19 (42%)
		C2H2 Zn finger	217..239	CDD:275368	6/21 (29%)
		zf-H2C2_2	231..256	CDD:290200	7/24 (29%)
		C2H2 Zn finger	247..267	CDD:275368	5/19 (26%)
		C2H2 Zn finger	275..296	CDD:275368	5/20 (25%)
		C2H2 Zn finger	304..324	CDD:275368	6/19 (32%)
		C2H2 Zn finger	331..351	CDD:275368
		C2H2 Zn finger	359..380	CDD:275368
ZNF621	NP_001091884.1	KRAB	11..71	CDD:214630
		COG4049	145..198	CDD:226535	14/44 (32%)
		C2H2 Zn finger	153..173	CDD:275368	7/19 (37%)
		zf-H2C2_2	166..190	CDD:316026	9/23 (39%)
		C2H2 Zn finger	209..229	CDD:275368	8/19 (42%)
		zf-H2C2_2	221..246	CDD:316026	13/26 (50%)
		C2H2 Zn finger	237..257	CDD:275368	6/21 (29%)
		C2H2 Zn finger	265..285	CDD:275368	5/19 (26%)
		zf-H2C2_2	281..302	CDD:316026	8/21 (38%)
		C2H2 Zn finger	293..313	CDD:275368	5/20 (25%)
		zf-H2C2_2	308..329	CDD:316026	7/20 (35%)
		C2H2 Zn finger	321..341	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100