DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32772 and ZNF449

DIOPT Version :9

Sequence 1:	NP_001284870.1	Gene:	CG32772 / 31420	FlyBaseID:	FBgn0052772	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_689908.3	Gene:	ZNF449 / 203523	HGNCID:	21039	Length:	518	Species:	Homo sapiens

Alignment Length:	276	Identity:	83/276 - (30%)
Similarity:	130/276 - (47%)	Gaps:	30/276 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 QQQQHQNPQQQQHQNSQQQQQQQQQMQSSSSSENLQSQDDSEDVDLIFNEEGSCPLCNKTFSRKS 144
            :.|....|:..|...::...||...:..:..:.||:.                 ||..|...:||
Human   270 ENQWETPPEDLQTDLAKLVDQQNPTLGETPENSNLEE-----------------PLNPKPHKKKS 317

  Fly   145 SLMTHIRNHSAERKFVCTYCHKGFTQAANLRNHERIHTNDRPYQCVDCGKTFTQITNLNNHRRLH 209
                     ..|:...|..|.|.|.:.:.|..|:|||:.:.|::|.:|||.|.:.::|..|:|||
Human   318 ---------PGEKPHRCPQCGKCFARKSQLTGHQRIHSGEEPHKCPECGKRFLRSSDLYRHQRLH 373

  Fly   210 TGERPFVCNEPECGRSFAQVTNLNNHMKSHHKVQQYCCNVCNKKFTQVTSLNQHLQAHAGVTGYY 274
            |||||:.|.  .|.:.|.:.::|..|.::|.:.:.|.|..|.|.|...:||.:||:.|.|...:.
Human   374 TGERPYECT--VCKKRFTRRSHLIGHQRTHSEEETYKCLECGKSFCHGSSLKRHLKTHTGEKPHR 436

  Fly   275 CPRCPEKNFKLQSQLHTHMKTHGLAFPYECDKCDEKFLQQAHLDQHLKMH-DEFKFKCDICPSSF 338
            |..| .|:|...:.|..|.:||....|::|:.|.:.|.|:..|..||::| .|..:||..|..||
Human   437 CHNC-GKSFSRLTALTLHQRTHTEERPFKCNYCGKSFRQRPSLVIHLRIHTGEKPYKCTHCSKSF 500

  Fly   339 NQESLLKKHVQRHVEG 354
            .|.:.|..|...|..|
Human   501 RQRAGLIMHQVTHFRG 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32772	NP_001284870.1	COG5048	<124..378	CDD:227381	76/232 (33%)
		C2H2 Zn finger	133..153	CDD:275368	5/19 (26%)
		zf-H2C2_2	145..170	CDD:290200	5/24 (21%)
		C2H2 Zn finger	161..181	CDD:275368	7/19 (37%)
		zf-H2C2_2	173..198	CDD:290200	11/24 (46%)
		C2H2 Zn finger	189..209	CDD:275368	8/19 (42%)
		C2H2 Zn finger	217..239	CDD:275368	5/21 (24%)
		zf-H2C2_2	231..256	CDD:290200	8/24 (33%)
		C2H2 Zn finger	247..267	CDD:275368	8/19 (42%)
		C2H2 Zn finger	275..296	CDD:275368	6/20 (30%)
		C2H2 Zn finger	304..324	CDD:275368	7/19 (37%)
		C2H2 Zn finger	331..351	CDD:275368	7/19 (37%)
		C2H2 Zn finger	359..380	CDD:275368
ZNF449	NP_689908.3	SCAN	27..134	CDD:322011
		SFP1	<235..402	CDD:227516	43/159 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..325		8/58 (14%)
		COG5048	<321..483	CDD:227381	57/164 (35%)
		C2H2 Zn finger	325..345	CDD:275368	7/19 (37%)
		C2H2 Zn finger	353..373	CDD:275368	8/19 (42%)
		C2H2 Zn finger	381..401	CDD:275368	5/21 (24%)
		C2H2 Zn finger	409..429	CDD:275368	8/19 (42%)
		C2H2 Zn finger	437..457	CDD:275368	6/20 (30%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		zf-H2C2_2	477..502	CDD:316026	10/24 (42%)
		C2H2 Zn finger	493..513	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100