DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32772 and ZNF274

DIOPT Version :9

Sequence 1:	NP_001284870.1	Gene:	CG32772 / 31420	FlyBaseID:	FBgn0052772	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_598009.1	Gene:	ZNF274 / 10782	HGNCID:	13068	Length:	653	Species:	Homo sapiens

Alignment Length:	345	Identity:	96/345 - (27%)
Similarity:	142/345 - (41%)	Gaps:	74/345 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SEQLTNNSNFHQSAAAAAAVAASASAAVAASAAAAATSSSTASSSDSDAIAQQQQHQN---PQQQ 90
            :::|..||:..:...|.:.....:|...|.|:....|............:.|.:..|.   ||::
Human   334 NKELAPNSDIPEEEPAPSLKVQESSRDCALSSTLEDTLQGGVQEVQDTVLKQMESAQEKDLPQKK 398

  Fly    91 QHQNSQQQ---------QQQQQQMQSSSSSENLQSQD------------------DSEDVDLIFN 128
            ...|.:.|         |...|::.:..|..|..:.|                  ||:...:..|
Human   399 HFDNRESQANSGALDTNQVSLQKIDNPESQANSGALDTNQVLLHKIPPRKRLRKRDSQVKSMKHN 463

  Fly   129 -----EEGSCPL--------CNKTFSRKSSLMTHIRNHSAERKFVCTYCHKGFTQAANLRNHERI 180
                 .:.||..        |.|||||.:..:|.||.|...:...|:.|.|.|........|::|
Human   464 SRVKIHQKSCERQKAKEGNGCRKTFSRSTKQITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKI 528

  Fly   181 HTNDRPYQCVDCGKTFTQITNLNNHRRLHTGERPFVCNEPECGRSFAQVTNLNNHMKSHHKVQQY 245
            ||.:|||.|.||||.|.|.::|..|:|:|:|||||.|.  ||||:|
Human   529 HTGERPYVCQDCGKGFVQSSSLTQHQRVHSGERPFECQ--ECGRTF------------------- 572

  Fly   246 CCNVCNKKFTQVTSLNQHLQAHAGVTGYYCPRCPEKNFKLQSQLHTHMKTHGLAFPYECDKCDEK 310
                 |.:    ::::|||:.|.|...|.|..| .|.|:..|.|..|.:||....||.|:||.:.
Human   573 -----NDR----SAISQHLRTHTGAKPYKCQDC-GKAFRQSSHLIRHQRTHTGERPYACNKCGKA 627

  Fly   311 FLQQAHLDQHLKMHDEFKFK 330
            |.|.:||..|.:.|:..|.|
Human   628 FTQSSHLIGHQRTHNRTKRK 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32772	NP_001284870.1	COG5048	<124..378	CDD:227381	75/220 (34%)
		C2H2 Zn finger	133..153	CDD:275368	10/27 (37%)
		zf-H2C2_2	145..170	CDD:290200	8/24 (33%)
		C2H2 Zn finger	161..181	CDD:275368	5/19 (26%)
		zf-H2C2_2	173..198	CDD:290200	13/24 (54%)
		C2H2 Zn finger	189..209	CDD:275368	10/19 (53%)
		C2H2 Zn finger	217..239	CDD:275368	6/21 (29%)
		zf-H2C2_2	231..256	CDD:290200	1/24 (4%)
		C2H2 Zn finger	247..267	CDD:275368	4/19 (21%)
		C2H2 Zn finger	275..296	CDD:275368	7/20 (35%)
		C2H2 Zn finger	304..324	CDD:275368	8/19 (42%)
		C2H2 Zn finger	331..351	CDD:275368	96/345 (28%)
		C2H2 Zn finger	359..380	CDD:275368
ZNF274	NP_598009.1	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..159
		SCAN	157..269	CDD:128708
		SCAN	157..245	CDD:280241
		KRAB	287..>327	CDD:214630
		KRAB	287..326	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..359		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..414		5/25 (20%)
		COG5048	<389..644	CDD:227381	85/285 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..485		5/36 (14%)
		C2H2 Zn finger	481..501	CDD:275368	9/19 (47%)
		C2H2 Zn finger	509..529	CDD:275368	5/19 (26%)
		zf-H2C2_2	521..546	CDD:290200	13/24 (54%)
		C2H2 Zn finger	537..557	CDD:275368	10/19 (53%)
		zf-H2C2_2	549..573	CDD:290200	15/49 (31%)
		zf-C2H2	563..585	CDD:278523	11/51 (22%)
		C2H2 Zn finger	565..585	CDD:275368	10/49 (20%)
		zf-C2H2	591..613	CDD:278523	8/22 (36%)
		C2H2 Zn finger	593..613	CDD:275368	7/20 (35%)
		zf-H2C2_2	605..630	CDD:290200	10/24 (42%)
		C2H2 Zn finger	621..641	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	632..653		6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100