DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6927 and glrba

DIOPT Version :9

Sequence 1:	NP_572194.1	Gene:	CG6927 / 31419	FlyBaseID:	FBgn0029733	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_571856.1	Gene:	glrba / 83412	ZFINID:	ZDB-GENE-010410-2	Length:	498	Species:	Danio rerio

Alignment Length:	526	Identity:	143/526 - (27%)
Similarity:	243/526 - (46%)	Gaps:	95/526 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 CPT------LDDGDSLSQTQLLDRLTHGCRYDRLERPITYSETGQRLPVDVYMRAYIYFMQNLEA 83
            ||:      ||...:.|.:.:|:||.  ..||...||     ..:.:||:..:..:|....:::.
Zfish    39 CPSQLSAEDLDRVPANSTSNILNRLL--MTYDSRIRP-----NFKGIPVEDKVNIFINSFGSIQE 96

  Fly    84 HDLQFKIYALLQMRYLDPRL----NFRN----VSPKRRQPILGEEHLRNSLWMPHIFLANERDSS 140
            ..:.:::...|:.|:.||||    :|::    |.||..|          .||.|.:|.|||::::
Zfish    97 TTMDYRVNIFLRQRWNDPRLRLPTDFKSDALTVDPKMFQ----------CLWKPDLFFANEKNAN 151

  Fly   141 ILGLTEKDILTSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCSTVLESWMYNTSELVLHWEQ 205
            ...:|:::||..|..:|.|::|.|:..||.|.|.|:.||.|.|:|...|||:.|.|.:||..|:.
Zfish   152 FHDVTQENILLFIFRNGDVLISMRLSVTLSCPLALQLFPMDTQYCKMQLESFGYTTKDLVFMWQS 216

  Fly   206 KRPITYDGALHLTEFVLQRSWSNETVINADLSDLRHGAFAGNYSSLSFTVHLTRVVGFYLMDYFL 270
            ..|:..| .:.|.:|.:::    |.:..|:.:....|  .|.|:.:.....|.|.||||:|..:.
Zfish   217 GDPVQMD-EIALPQFDVKQ----EDIKYANCTKFYPG--TGYYTCVEVIFTLRRQVGFYMMGVYA 274

  Fly   271 PSMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQGKTLPKVSYIKVSEVWFLGCTIFI 335
            |::|||.:||:|||:..|.:..|:.||..::|:..:..::....||||||:|..::|.:.|.::.
Zfish   275 PTLLIVVLSWLSFWINPDASAARVPLGILSVLSLSSECTSLASELPKVSYVKAIDIWMIACLLYG 339

  Fly   336 FGSMVEFAFVNTIWRRKKSVPVKKLNSKHILKSTLSPNLLRRRSHARSRSFSGTALHKT-ADTGS 399
            |.|:||:|.|..:....|.:..:|:.             :..:..||.:.      :|| |.|.|
Zfish   340 FASLVEYAVVQVMLNSPKRIEAEKIK-------------MAEKEKAREKE------NKTPAKTNS 385

  Fly   400 LGGAGFNNYLTVNLPITTIKEGQVLDQQRTSRVVQKMDV-------------NFVESAFGSMGSA 451
            ..|.|     ...:.::|:   ||::.:.......|.|:             :|..|.|...|.
Zfish   386 ANGTG-----GTPIHVSTL---QVVENRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNFDCYGK- 441

  Fly   452 QSTGAISAASSSQTLTNNNRTESAGHQEEIDLSGWTTLTPQEIAMWIDSRARFVFPLSFLVFNLF 516
                .|....:|....|.|..:.|..:..|          ...|..:|..||.:||.:||.||:.
Zfish   442 ----PIEVTDASGKPQNKNNKKPAPPKPVI----------PSAAKRVDLYARALFPFTFLFFNVI 492

  Fly   517 FWTFVY 522
            :|: ||
Zfish   493 YWS-VY 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:273305	141/522 (27%)
		Neur_chan_LBD	36..259	CDD:280998	64/230 (28%)
		Neur_chan_memb	270..518	CDD:280999	65/261 (25%)
glrba	NP_571856.1	LIC	52..497	CDD:273305	137/511 (27%)
		Neur_chan_LBD	59..265	CDD:280998	65/229 (28%)
		Neur_chan_memb	272..494	CDD:280999	65/263 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910