DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6927 and Gabrp

DIOPT Version :9

Sequence 1:	NP_572194.1	Gene:	CG6927 / 31419	FlyBaseID:	FBgn0029733	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_112291.1	Gene:	Gabrp / 81658	RGDID:	620532	Length:	440	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	120/542 - (22%)
Similarity:	231/542 - (42%)	Gaps:	128/542 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEWSLIIS-ILLN------CLYASASALDEDCPTLDDGDSLSQTQLLDRLTHGCRYDRLERPITY 58
            |.:||.:: :.||      |:..:...::     :...|.||... .:.||.|  |::..||...
  Rat     1 MSYSLYLAFVCLNLLAQRMCIQGNQFNVE-----VSRSDKLSLPG-FENLTAG--YNKFLRPNFG 57

  Fly    59 SETGQRLPVDVYMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRLNFRNVSPKRRQPILGEEHLR 123
            .:     ||.:.:...|..:.::...::.:.....|:.|:.||||.|..     .:....:..|.
  Rat    58 GD-----PVRIALTLDIASISSISESNMDYTATIYLRQRWTDPRLVFEG-----NKSFTLDARLV 112

  Fly   124 NSLWMPHIFLANERDSSILGLTEKDILTSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCSTV 188
            ..||:|..::...:.|.:..:|..:.|..:..:|||:.:.||..|:.|.::|.|:|.|.|.|...
  Rat   113 EFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVTCNMDLSKYPMDTQTCKLQ 177

  Fly   189 LESWMYNTSELVLHW----EQKRPITYDGALHLTEFVLQRSWSNETVINADLSDLRHGAFAGNYS 249
            ||||.|:.:::...|    :..|.:.   .|.|.::.:|:.::..||...:         .|||:
  Rat   178 LESWGYDGNDVEFSWLRGNDSVRGLE---NLRLAQYTIQQYFTLVTVSQQE---------TGNYT 230

  Fly   250 SLSFTVHLTRVVGFYLMDYFLPSMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQGKT 314
            .|.....|.|.|.:::::.::||..:|.:||||||:..:..|.|..:|.:|:|:..||......:
  Rat   231 RLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLESVPARTCIGVTTVLSMTTLMIGSRTS 295

  Fly   315 LPKVS-YIKVSEVWFLGCTIFIFGSMVEFAFVNTIWRRKKSV----PVK---KLNSKHILKSTLS 371
            ||..: :||..:|:...|..|:||:::|:|..:....::.:|    |.|   ::|..:|:.|::|
  Rat   296 LPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAVKDRGPAKDSEEVNITNIINSSIS 360

  Fly   372 PNLLRRRSHARSRSFSGTALHKTADTGSLGGAGFNNYLTVNLPITTIKEG---QVLDQQRTSRVV 433
                   |..|..||:           |:..:|.|    ||....|:|..   :.:.:::..|::
  Rat   361 -------SFKRKISFA-----------SIEISGDN----VNYSDLTMKASDKFKFVFREKIGRII 403

  Fly   434 QKMDVNFVESAFGSMGSAQSTGAISAASSSQTLTNNNRTESAGHQEEIDLSGWTTLTPQEIAMWI 498
            ...                            |:.|.:.                          :
  Rat   404 DYF----------------------------TIQNPSN--------------------------V 414

  Fly   499 DSRARFVFPLSFLVFNLFFWTF 520
            |..::.:|||.|::.|:|:|.:
  Rat   415 DRYSKLLFPLIFMLANVFYWAY 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:273305	119/538 (22%)
		Neur_chan_LBD	36..259	CDD:280998	53/226 (23%)
		Neur_chan_memb	270..518	CDD:280999	55/258 (21%)
Gabrp	NP_112291.1	LIC	43..437	CDD:273305	111/494 (22%)
		LGIC_ECD	60..241	CDD:355788	47/197 (24%)
		Cys-loop	159..174	CDD:349787	6/14 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900