Protein Alignment CG6927 and GLRA3

DIOPT Version :9

• Sequence 1: NP_572194.1
• Gene: CG6927 / 31419
• FlyBaseID: FBgn0029733
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_006520.2
• Gene: GLRA3 / 8001
• HGNCID: 4328
• Length: 464
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 143/542 - (26%)
• Similarity: 240/542 - (44%)
• Gaps: 125/542 - (23%)

  Fly     3 WSLIISILLNCLYASASALDEDCPTLDDGDSLSQTQLLDRL---THGCRYDRLERPITYSETGQR 64
            |...:.:.|.....:.||.....|       :|.:..||:|   |.|  ||...||     ..:.
Human    17 WEAALLLSLVATKETDSARSRSAP-------MSPSDFLDKLMGRTSG--YDARIRP-----NFKG 67

  Fly    65 LPVDVYMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRLNFR-------NVSPKRRQPILGEEHL 122
            .||:|....:|....::....:.:::...|:.::.||||.:.       ::.|.          :
Human    68 PPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPS----------M 122

  Fly   123 RNSLWMPHIFLANERDSSILGLTEKDILTSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCST 187
            .:|:|.|.:|.|||:.::...:|..:.|..|..:|.|:.|.|:..||.|.::||.||.|.|.|..
Human   123 LDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIM 187

  Fly   188 VLESWMYNTSELVLHWEQKRPITYDGALHLTEFVLQRSWSNETVINADLSDLRHGA---FAGNYS 249
            .|||:.|..::|:..|:.:.|:.....|.|.:|:|:..           .|||:..   ..|.::
Human   188 QLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEE-----------KDLRYCTKHYNTGKFT 241

  Fly   250 SLSFTVHLTRVVGFYLMDYFLPSMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQGKT 314
            .:....||.|.:|:||:..::||:|||.:||||||:..|.||.|:.||.:|:||..|.:|....:
Human   242 CIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRAS 306

  Fly   315 LPKVSYIKVSEVWFLGCTIFIFGSMVEFAFVNTIWRRKKSVPVKKLNSKHILKSTLSPNLLRRRS 379
            ||||||:|..::|...|.:|:|.:::|:|.||.:.|:          .|.:|:       .||:.
Human   307 LPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQ----------HKELLR-------FRRKR 354

  Fly   380 HARSRSFSGTALHKTADTGSLGGAGFNNYLTVNLPITTIKEGQVLDQQRTSRVVQKMDVNFVESA 444
            ..::.:|:....::.:|..                          |:.|.||        |..:|
Human   355 KNKTEAFALEKFYRFSDMD--------------------------DEVRESR--------FSFTA 385

  Fly   445 FGSMGSAQSTGAISAASSSQTLTNNNRTESAGHQEEIDLSGWTTLTPQEI-------AMWIDSRA 502
            :|       .|....|....|....|      |..::     ...:|.|:       |..||:.:
Human   386 YG-------MGPCLQAKDGMTPKGPN------HPVQV-----MPKSPDEMRKVFIDRAKKIDTIS 432

  Fly   503 RFVFPLSFLVFNLFFWTFVYCI 524
            |..|||:||:||:|:|. :|.|
Human   433 RACFPLAFLIFNIFYWV-IYKI 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:273305	141/536 (26%)
		Neur_chan_LBD	36..259	CDD:280998	60/235 (26%)
		Neur_chan_memb	270..518	CDD:280999	70/254 (28%)
GLRA3	NP_006520.2	LIC	12..451	CDD:273305	141/538 (26%)
		Strychnine-binding. /evidence=ECO:0000269|PubMed:26416729	235..240		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910