DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6927 and Gabrq

DIOPT Version :9

Sequence 1:	NP_572194.1	Gene:	CG6927 / 31419	FlyBaseID:	FBgn0029733	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_065234.1	Gene:	Gabrq / 57249	MGIID:	1888498	Length:	638	Species:	Mus musculus

Alignment Length:	634	Identity:	136/634 - (21%)
Similarity:	263/634 - (41%)	Gaps:	155/634 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IISILLNCLYASASALDEDCPTLDDGDSLSQTQLLDRLTHGCRYDRLERPITYSETGQRLPVDVY 70
            :|..|.||...:..|:.:              ::|||:.  ..||...||   :..|..:||.|.
Mouse    43 VILDLFNCKNCANEAVVQ--------------KILDRVL--STYDVRLRP---NFGGAPVPVSVS 88

  Fly    71 MRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRLNFRNVSPKRRQPILGEEHLRNSLWMPHIFLAN 135
            :  |:..::.:...::.:.|...|...:.|.||.:...:..    :..:..:...||:|..:..|
Mouse    89 I--YVSSIEQISEINMDYTITMFLHQTWKDTRLAYYETNLN----LTLDYRMHEKLWVPDCYFVN 147

  Fly   136 ERDSSILGLTEKDILTSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCSTVLESWMYNTSELV 200
            .:|:.:..:|.::.:..:.|||||....|:..|..|.|:|:|||.|:|.|...:||:.|...::|
Mouse   148 SKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTTAACSLDLQKFPMDKQSCKLEVESYGYTVEDIV 212

  Fly   201 LHWEQKRPITYDGALHLTE--FVLQRSWSNETVINADLSDLRHGAFAGNYSSLSFTVHLTRVVGF 263
            |.||.      |.|:|:|:  .:.|.::...|:.:.::.     .:.|:|..|.....:.|.|..
Mouse   213 LSWED------DNAIHITDGLHIPQYTYLGRTITSKEVY-----FYTGSYMRLIVKFQVQREVRS 266

  Fly   264 YLMDYFLPSMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQGKTLPKVSYIKVSEVWF 328
            ||:..:.|::|...:||:|||:..|.:..|:|:|.:::|...|:.|.....||.:|.||..:::.
Mouse   267 YLVQVYWPTVLTTILSWISFWMNYDSSAARVTIGLTSILVLTTIDSHMRDKLPHISCIKAIDIYI 331

  Fly   329 LGCTIFIFGSMVEFAFVNTIW------------RRKKSVPVKKLNSKHILKSTLSPNLLR----- 376
            |.|..|:|.|::|:.::|.::            |:.:.| |.:...:.::.:.:...|:.
Mouse   332 LVCLFFVFLSLLEYVYINYLFFSQVPRRNHRRCRKPRRV-VARYRYQEVVVANVQDGLINVEDRV 395

  Fly   377 -----------RRSHARSRSFSGTALHKTADTGSLGGAGFNNYLTVNLPITTIKEGQVL-DQQRT 429
                       .::|..|:...|:.:. |::...|..:...:.|:.....|.:..|:.| |...|
Mouse   396 EDRAGPLPDSPMQAHLASQESLGSLVF-TSEQAQLATSESLSLLSSASSQTQLATGESLSDLPST 459

  Fly   430 S-RVVQKMDVNF----------------------VESAFGSMGSAQSTGAISAASSSQTLTNNNR 471
            | :.|.:..::|                      .|.:..|:.|.:|.|..|:.:....|..:.|
Mouse   460 SEQTVPECTIHFHGFLTNDSIIPIKIHSRSDACDDEDSEESLSSEESHGHGSSHTGRLKLQISQR 524

  Fly   472 --TESAGHQEEIDL--------SGWT--------------TLTPQEIAMW--------------- 497
              .|::...::|::        |.|.              :||.:|:...
Mouse   525 CVQEASWDLDKIEILQDDISITSSWLGLDEQCKGDADSIWSLTDEELMACDQEKDSSSESEENCS 589

  Fly   498 -----------------------IDSRARFVFPLSFLVFNLFFWTF-VY 522
                                   :|..:||:|||||.:||:.:|.: ||
Mouse   590 PSPGCSFNEGFSFQLFKPNRVPKVDRWSRFLFPLSFGLFNVVYWLYHVY 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:273305	134/629 (21%)
		Neur_chan_LBD	36..259	CDD:280998	55/224 (25%)
		Neur_chan_memb	270..518	CDD:280999	69/361 (19%)
Gabrq	NP_065234.1	LGIC_ECD_GABAAR_theta	82..263	CDD:349804	47/197 (24%)
		Cys-loop	183..197	CDD:349804	8/13 (62%)
		LGIC_TM_GABAAR_theta	266..365	CDD:349858	28/98 (29%)
		TM1 helix	266..289	CDD:349858	9/22 (41%)
		TM2 helix	293..317	CDD:349858	6/23 (26%)
		TM3 helix	325..351	CDD:349858	8/25 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..515		6/23 (26%)
		LGIC_TM	<604..636	CDD:365787	11/31 (35%)
		TM4 helix	612..633	CDD:349850	10/20 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810