Protein Alignment CG6927 and nAChRalpha4

DIOPT Version :9

• Sequence 1: NP_572194.1
• Gene: CG6927 / 31419
• FlyBaseID: FBgn0029733
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Alignment Length: 587
• Identity: 112/587 - (19%)
• Similarity: 192/587 - (32%)
• Gaps: 222/587 - (37%)

  Fly    49 YDRLERPITYSETGQRLPVDVYMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRLNFRNVSPKRR 113
            |::|.||:.  .|...|.|.:.::.......||:...:...::  ::..:.|.:|.:   .||.
  Fly    23 YNKLVRPVV--NTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLW--VEQSWYDYKLRW---EPKE- 79

  Fly   114 QPILGEEHL----RNSLWMPHIFLANERDSSILGLTEKDILTSISPDGTVIVSNRIKATLY---- 170
               .|..|:    .:.:|.|.|.|.|                  :.||...|:...|||:|
  Fly    80 ---YGGVHMLHVPSDHIWRPDIVLYN------------------NADGNFEVTLATKATIYSEGL 123

  Fly   171 ------------CWLNLKKFPFDEQHCSTVLESWMYNTSELVLHWEQKRPITYDG----ALHLTE 219
                        |.::::.||||||.|.....||                 ||||    ..|:.|
  Fly   124 VEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSW-----------------TYDGFKVDLRHMDE 171

  Fly   220 FVLQRSWSNETVINADLSD--------------LRHGAF----AGNYSSLSFTVHLTRVVGFYLM 266
                :..||...:..|||:              :|:..|    ...|..::|.:.:.|...||.:
  Fly   172 ----QQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTV 232

  Fly   267 DYFLPSMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQGKTLPKVSYIKVSEVWFLGC 331
            :..:|.|.|..::.::|:|.:|.. .::||..|.|::.........:.:|..|.:
  Fly   233 NIIIPCMGISFLTVLTFYLPSDSG-EKVTLSISILISLHVFFLLVVEIIPPTSLV---------- 286

  Fly   332 TIFIFGSMVEFAFV-------------NTIWR---RKKSVP-VKKL------------------- 360
             :.:.|..:.||.:             |..:|   ..|..| ||::
  Fly   287 -VPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLPAFLFIKRPTYNFE 350

  Fly   361 NSKHILKSTLSPNLLRRRSHARSRSFSGTALHKTADTGSLGGAGFNNYL---------TVN---- 412
            .||.:||.|          ||....:     :...:...|..:|:||.|         |.|
  Fly   351 TSKLLLKDT----------HACFYPY-----YSATNIDRLVSSGYNNSLPKEDLSQSITANGPFG 400

  Fly   413 ---------LPITTIKEGQVLDQQRTSRVVQKMDVNFVESAFGSMGSAQSTGAISAASSSQTLTN 468
                     .|:|.....::       ..|..||:       |.:|.........|.|.|:.|..
  Fly   401 GSCQVHGPVPPLTHCSSDEI-------AAVPDMDI-------GPLGMKSPILNNPAFSHSKCLPK 451

  Fly   469 NNRT--------ESAGHQEEIDLSGWTTLTPQE---IAMWIDSRARFVFPLSFLVFNLFFWTFVY 522
            .:::        |....||:      :|...::   :||.:|              .||.|.|..
  Fly   452 IHKSCFCVRFIAEHTKMQED------STKVKEDWKYVAMVLD--------------RLFLWIFTL 496

  Fly   523 CI 524
            .:
  Fly   497 AV 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:273305	111/581 (19%)
		Neur_chan_LBD	36..259	CDD:280998	52/251 (21%)
		Neur_chan_memb	270..518	CDD:280999	55/316 (17%)
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	112/587 (19%)
		Neur_chan_LBD	12..227	CDD:280998	53/253 (21%)
		Neur_chan_memb	234..505	CDD:280999	57/326 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447267
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030