DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6927 and pHCl-1

DIOPT Version :9

Sequence 1:	NP_572194.1	Gene:	CG6927 / 31419	FlyBaseID:	FBgn0029733	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001261898.1	Gene:	pHCl-1 / 39730	FlyBaseID:	FBgn0264908	Length:	978	Species:	Drosophila melanogaster

Alignment Length:	504	Identity:	119/504 - (23%)
Similarity:	195/504 - (38%)	Gaps:	119/504 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SILLNCLY----ASASALDEDCPTLDD-----------GDSLSQTQLLDRLTHGCRYDR------ 51
            |:||...|    ::|:|...:...||.           .:|.|..::||.|....|||:
  Fly   294 SVLLMLCYLTTASTAAATQSETGALDKHPIHGIDWSKFDESSSDKEILDLLLEKKRYDKRLLPPV 358

  Fly    52 --------LERPITYSETGQRLP-----VDVYMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRL 103
                    |:.|...:....|.|     :.|.:...:..:.:.:...|::::..||..::.||||
  Fly   359 NDEDFCCGLQSPDMATNQNARRPHNRGTLTVNVNVLLLSLASPDESSLKYEVEFLLNQQWNDPRL 423

  Fly   104 NFRNVSPKRRQPILGEEHLRNSLWMPHIFLANERDSSILGLTEKD------ILTSISPDGTVIVS 162
            .:.|   |.....|...|..:|:|.|..:.....|.       ||      ....|..:||:..:
  Fly   424 QYGN---KSHYDFLNALHHHDSIWTPDTYFIMHGDF-------KDPIIPMHFALRIFRNGTITYA 478

  Fly   163 NRIKATLYCWLNLKKFPFDEQHCSTVLESWMYNTSELVLHWEQKRPITYDGALHLTEFVLQRSWS 227
            .|....|.|..:|..||||:..||..:||..|..:::...|:.            .|..|::|.|
  Fly   479 MRRHLILSCQGSLHIFPFDDPKCSFSMESISYEEAQIKYVWKN------------DEDTLRKSPS 531

  Fly   228 ----NETVINADLSDLRHGAFAGNYSSLSFTVHLTRVVGFYLMDYFLPSMLIVAISWVSFWLQAD 288
                |..:|....:.....::.||||.|...:..||...:|....|:|.:::|..|:::|||:.:
  Fly   532 LTTLNAYLIKNQTTACDQNSWRGNYSCLQVELTFTRDRAYYFTTVFIPGIILVTSSFITFWLEWN 596

  Fly   289 QAPPRITLGTSTLLTFITLASAQGKTLPKVSYIKVSEVWFLGCTIFIFGSMVEFAFVNTIWRRKK 353
            ..|.|:.:|.:|:|.|.|.::....|||.||.:....||...|..||:.|::||..||.:.|::
  Fly   597 AVPARVMIGVTTMLNFFTTSNGFRSTLPVVSNLTAMNVWDGVCMCFIYASLLEFVCVNYVGRKR- 660

  Fly   354 SVPVKKLNSKHILKSTLSPNLLRRRSHARSRSFSGTALHKTADTGSLGGAGFNNYLTVNLPITTI 418
              |:.              |::.|..                          .|.:|..||....
  Fly   661 --PLH--------------NVVYRPG--------------------------ENPVTQRLPAVLS 683

  Fly   419 KEGQVLDQQRTSRVVQKMDVNFVESAFGSMGSA--QSTGAISAASSSQT 465
            :.|.:|.....|..        ...|...||.|  .|:|..:|:||..|
  Fly   684 RIGVILASPLASAA--------ATPAMSMMGGATPMSSGTPAASSSVAT 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:273305	119/504 (24%)
		Neur_chan_LBD	36..259	CDD:280998	56/251 (22%)
		Neur_chan_memb	270..518	CDD:280999	49/198 (25%)
pHCl-1	NP_001261898.1	Neur_chan_LBD	338..566	CDD:280998	56/249 (22%)
pHCl-1	NP_001261898.1	Neur_chan_memb	578..>682	CDD:280999	36/146 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5256
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.960