DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6927 and Gabra6

DIOPT Version :9

Sequence 1:	NP_572194.1	Gene:	CG6927 / 31419	FlyBaseID:	FBgn0029733	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_068613.1	Gene:	Gabra6 / 29708	RGDID:	61861	Length:	453	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	114/515 - (22%)
Similarity:	215/515 - (41%)	Gaps:	118/515 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DDGDSLSQ--TQLLDRLTHGCRYDRLERP-----ITYSETGQRLPVDVYMRAYIYFMQNLEAHDL 86
            |:|:..|:  :::||.|..|  ||...||     :|..:|      |:|:.::    ..:...::
  Rat    23 DEGNFYSENVSRILDNLLEG--YDNRLRPGFGGAVTEVKT------DIYVTSF----GPVSDVEM 75

  Fly    87 QFKIYALLQMRYLDPRLNFRNVSPKRRQPILGEEHLR-NSLWMPHIFLANERDSSILGLTEKDIL 150
            ::.:....:..:.|.||.|:..:     .||...:|. :.:|.|..|..|.:.|....:|..:.|
  Rat    76 EYTMDVFFRQTWTDERLKFKGPA-----EILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKL 135

  Fly   151 TSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCSTVLESWMYNTSELVLHWEQKRPITYDGAL 215
            ..:..:||::.:.|:.....|.:.|..||.|...|.....|:.|..||::..|::       |.|
  Rat   136 FRLMHNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKK-------GPL 193

  Fly   216 HLTEF------VLQRSWSNETVINADLSDLRHGAFAGNYSSLSFTVHLTRVVGFYLMDYFLPSML 274
            :..|.      :||.....:||.:..:.     :..|.|..::...||.|.:|::::..:.|.::
  Rat   194 YSVEVPEESSSLLQYDLIGQTVSSETIK-----SNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIM 253

  Fly   275 IVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQGKTLPKVSYIKVSEVWFLG-CTIFIFGS 338
            .|.:|.||||:..:..|.|...|.:|:||..||:.:...:||||||....: ||:. |..|:|.:
  Rat   254 TVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMD-WFIAVCFAFVFSA 317

  Fly   339 MVEFAFVNTIWRRKKSVPVKKLNSKHILKSTLSPNLLRRRSHARSRSFSGTALHKTADTGSLGGA 403
            ::|||.||..                       .||..:::..::::.:...:.|:..|.||
  Rat   318 LIEFAAVNYF-----------------------TNLQSQKAERQAQTAAKPPVAKSKTTESL--- 356

  Fly   404 GFNNYLTVNLPITTIKEGQVLDQQRTSRVVQKMDVNFVESAFGSMGSAQSTGAISAASSSQTLTN 468
                            |.:::....:...::|..            |:.:...:.::.:|:.|:.
  Rat   357 ----------------EAEIVVHSDSKYHLKKRI------------SSLTLPIVPSSEASKVLSR 393

  Fly   469 NNRTESAGHQEEIDLSGWTTLTPQEI------AMWIDSRARFVFPLSFLVFNLFFWTFVY 522
            .....|            |.:||..:      ...||..:|.:||::|..|||.:| .||
  Rat   394 TPILPS------------TPVTPPLLLPAIGGTSKIDQYSRILFPVAFAGFNLVYW-IVY 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:273305	112/511 (22%)
		Neur_chan_LBD	36..259	CDD:280998	51/236 (22%)
		Neur_chan_memb	270..518	CDD:280999	55/254 (22%)
Gabra6	NP_068613.1	Neur_chan_LBD	33..240	CDD:280998	52/235 (22%)
		LIC	34..440	CDD:273305	109/502 (22%)
		Neur_chan_memb	247..437	CDD:280999	55/256 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900