DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6927 and Gabra5

DIOPT Version :9

Sequence 1:	NP_572194.1	Gene:	CG6927 / 31419	FlyBaseID:	FBgn0029733	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_058991.2	Gene:	Gabra5 / 29707	RGDID:	61859	Length:	464	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	120/495 - (24%)
Similarity:	207/495 - (41%)	Gaps:	110/495 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TQLLDRLTHGCRYDRLERPITYSETGQRLP---VDVYMRAYIYFMQNLEAHDLQFKIYALLQMRY 98
            |::||.|..|  ||...||    ..|:|:.   .|:|:.::    ..:...::::.|....:..:
  Rat    50 TRILDGLLDG--YDNRLRP----GLGERITQVRTDIYVTSF----GPVSDTEMEYTIDVFFRQSW 104

  Fly    99 LDPRLNFRNVSPKRRQPILGEEHLRNSLWMPHIFLANERDSSILGLTEKDILTSISPDGTVIVSN 163
            .|.||.|:  .|.:|.|:  ...|.:.:|.|..|..|.:.|....:|..:.|..:..|||::.:.
  Rat   105 KDERLRFK--GPMQRLPL--NNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTM 165

  Fly   164 RIKATLYCWLNLKKFPFDEQHCSTVLESWMYNTSELVLHW---EQKRPITYDGALHLTEFVLQRS 225
            |:..:..|.:.|:.||.|...|.....|:.|..||:|..|   ..|..:..:....|.::.|.
  Rat   166 RLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLM-- 228

  Fly   226 WSNETVINADLSDLRHGAFAGNYSSLSFTVHLTRVVGFYLMDYFLPSMLIVAISWVSFWLQADQA 290
              .:||...::|     ...|.|:.::...||.|.:|::::..:||.::.|.:|.|||||..:..
  Rat   229 --GQTVGTENIS-----TSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESV 286

  Fly   291 PPRITLGTSTLLTFITLASAQGKTLPKVSYIKVSEVWFLG-CTIFIFGSMVEFAFVNTI------ 348
            |.|...|.:|:||..||:.:...:||||:|....: ||:. |..|:|.:::|||.||..
  Rat   287 PARTVFGVTTVLTMTTLSISARNSLPKVAYATAMD-WFIAVCYAFVFSALIEFATVNYFTKRGWA 350

  Fly   349 WRRKKSVPVKKLNSKHILKSTLSPNLLRRRSHARSRSFSGTALHKTADTGSLGGAGFNNYLTVNL 413
            |..||::...|:..|.      ...:|.:.::|.:   :|...|..                 |:
  Rat   351 WDGKKALEAAKIKKKE------RELILNKSTNAFT---TGKLTHPP-----------------NI 389

  Fly   414 PITTIKEGQVLDQQRTSRVVQKMDVNFVESAFGSMGSAQSTGAISAASSSQTLTNNNRTESAGHQ 478
            |                          .|...|..|:|..|.:|.|  |.:..:.:.:|.::..:
  Rat   390 P--------------------------KEQLPGGTGNAVGTASIRA--SEEKTSESKKTYNSISK 426

  Fly   479 EEIDLSGWTTLTPQEIAMWIDSRARFVFPLSFLVFNLFFW 518
                               ||..:|.|||:.|..|||.:|
  Rat   427 -------------------IDKMSRIVFPILFGTFNLVYW 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:273305	120/495 (24%)
		Neur_chan_LBD	36..259	CDD:280998	55/227 (24%)
		Neur_chan_memb	270..518	CDD:280999	62/254 (24%)
Gabra5	NP_058991.2	LIC	15..450	CDD:273305	120/495 (24%)
		LGIC_ECD_GABAAR_A5	58..256	CDD:349839	51/220 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..414		11/76 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810