DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6927 and GLRB

DIOPT Version :9

Sequence 1:NP_572194.1 Gene:CG6927 / 31419 FlyBaseID:FBgn0029733 Length:524 Species:Drosophila melanogaster
Sequence 2:NP_000815.1 Gene:GLRB / 2743 HGNCID:4329 Length:497 Species:Homo sapiens


Alignment Length:530 Identity:146/530 - (27%)
Similarity:231/530 - (43%) Gaps:109/530 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 CPTLDDGDSL------SQTQLLDRLTHGCRYDRLERPITYSETGQRLPVDVYMRAYIYFMQNLEA 83
            ||:....:.|      |.:.:|:||.  ..||...||     ..:.:||||.:..:|....:::.
Human    39 CPSQQSAEDLARVPANSTSNILNRLL--VSYDPRIRP-----NFKGIPVDVVVNIFINSFGSIQE 96

  Fly    84 HDLQFKIYALLQMRYLDPRL----NFRNVSPKRRQPILGEEHLRNSLWMPHIFLANERDSSILGL 144
            ..:.:::...|:.::.||||    :||........|.     :...||.|.:|.|||:.::...:
Human    97 TTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPT-----MYKCLWKPDLFFANEKSANFHDV 156

  Fly   145 TEKDILTSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCSTVLESWMYNTSELVLHWEQKRPI 209
            |:::||..|..||.|:||.|:..||.|.|:|..||.|.|.|...|||:.|.|.:|...|:...|:
Human   157 TQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPV 221

  Fly   210 TYDGALHLTEFVLQRSWSNETVINADLSDLRHG------AFAGNYSSLSFTVHLTRVVGFYLMDY 268
            ..: .:.|.:|.:::            .|:.:|      ...|.|:.:.....|.|.||||:|..
Human   222 QLE-KIALPQFDIKK------------EDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGV 273

  Fly   269 FLPSMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQGKTLPKVSYIKVSEVWFLGCTI 333
            :.|::|||.:||:|||:..|.:..|:.||..::|:..:..:.....||||||:|..:||.:.|.:
Human   274 YAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLL 338

  Fly   334 FIFGSMVEFAFVNTIWRRKKSVPVKKLNSKHILKSTLSPNLLRRRSHARSRSFSGTALHKTADTG 398
            |.|.|:||:|.|..:....|.|..:|                     ||      .|..:.|| |
Human   339 FGFASLVEYAVVQVMLNNPKRVEAEK---------------------AR------IAKAEQAD-G 375

  Fly   399 SLGGAGFNNYLTVN-----LPITTIKEGQVLDQQRTSRV-VQKMDVNFVESAFGSMGSAQSTGAI 457
            ..|.....|  |||     :.|:|::.|:.    |..:| ..|.|:.  .:.|..:||......:
Human   376 KGGNVAKKN--TVNGTGTPVHISTLQVGET----RCKKVCTSKSDLR--SNDFSIVGSLPRDFEL 432

  Fly   458 S-------------AASSSQTLTNNNRTESAGHQEEIDLSGWTTLTPQEIAMWIDSRARFVFPLS 509
            |             ....||. .||.:...|           ..:.| ..|..||..||.:||..
Human   433 SNYDCYGKPIEVNNGLGKSQA-KNNKKPPPA-----------KPVIP-TAAKRIDLYARALFPFC 484

  Fly   510 FLVFNLFFWT 519
            ||.||:.:|:
Human   485 FLFFNVIYWS 494

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6927NP_572194.1 LIC 3..520 CDD:273305 146/530 (28%)
Neur_chan_LBD 36..259 CDD:280998 62/232 (27%)
Neur_chan_memb 270..518 CDD:280999 73/266 (27%)
GLRBNP_000815.1 LIC 43..496 CDD:273305 144/526 (27%)
LGIC_ECD_GlyR_beta 79..265 CDD:349811 55/203 (27%)
Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430 247..253 1/5 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3644
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18945
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.910

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