Protein Alignment CG6927 and GLRA2

DIOPT Version :9

• Sequence 1: NP_572194.1
• Gene: CG6927 / 31419
• FlyBaseID: FBgn0029733
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_001112357.1
• Gene: GLRA2 / 2742
• HGNCID: 4327
• Length: 452
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 142/531 - (26%)
• Similarity: 232/531 - (43%)
• Gaps: 122/531 - (22%)

  Fly    10 LLNCLYA---------SASALDEDCPT-LDDGDSLSQTQLLDRL---THGCRYDRLERPITYSET 61
            :|..|:|         :|...|.|..: .....:||.:..||:|   |.|  ||...||     .
Human     8 ILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSG--YDARIRP-----N 65

  Fly    62 GQRLPVDVYMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRLNFR-------NVSPKRRQPILGE 119
            .:..||:|....:|....::....:.:::...|:.::.|.||.:.       ::.|.
Human    66 FKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPS-------- 122

  Fly   120 EHLRNSLWMPHIFLANERDSSILGLTEKDILTSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQH 184
              :.:|:|.|.:|.|||:.::...:|..:.|..||.:|.|:.|.|:..||.|.::||.||.|.|.
Human   123 --MLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQT 185

  Fly   185 CSTVLESWMYNTSELVLHWEQKRPITYDGALHLTEFVLQRSWSNETVINADLSDLRHGAFAGNYS 249
            |:..|||:.|..::|:..|....|:.....|.|.:|:|:.        ..:|.........|.::
Human   186 CTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKE--------EKELGYCTKHYNTGKFT 242

  Fly   250 SLSFTVHLTRVVGFYLMDYFLPSMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQGKT 314
            .:....||.|.:|:||:..::||:|||.:||||||:..|.||.|:.||.:|:||..|.:|....:
Human   243 CIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRAS 307

  Fly   315 LPKVSYIKVSEVWFLGCTIFIFGSMVEFAFVNTIWRRKKSVPVKKLNSKHILKSTLSPNLLRRRS 379
            ||||||:|..::|...|.:|:|.:::|:|.||.:.|:          .|..|:       ||||.
Human   308 LPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQ----------HKEFLR-------LRRRQ 355

  Fly   380 HARSRSFSGTALHKTADTGSLGGAGFNNYLTVNLPITTIKEGQVLDQQRTSRVVQKMDVNFVESA 444
            ..::                                   ||..|..:.|         .||  |.
Human   356 KRQN-----------------------------------KEEDVTRESR---------FNF--SG 374

  Fly   445 FGSMGSAQST--GAISAASSSQTLTNNNRTESAGHQEEIDLSGWTTLTPQEIAMWIDSRARFVFP 507
            :| ||.....  |....|:.:..|....:...|..::.:|.           |..||:.:|..||
Human   375 YG-MGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDR-----------AKRIDTISRAAFP 427

  Fly   508 LSFLVFNLFFW 518
            |:||:||:|:|
Human   428 LAFLIFNIFYW 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:273305	142/531 (27%)
		Neur_chan_LBD	36..259	CDD:280998	58/232 (25%)
		Neur_chan_memb	270..518	CDD:280999	71/249 (29%)
GLRA2	NP_001112357.1	LIC	46..441	CDD:273305	134/493 (27%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	236..241		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910