DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6927 and GABRR1

DIOPT Version :9

Sequence 1:	NP_572194.1	Gene:	CG6927 / 31419	FlyBaseID:	FBgn0029733	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_002033.2	Gene:	GABRR1 / 2569	HGNCID:	4090	Length:	479	Species:	Homo sapiens

Alignment Length:	498	Identity:	115/498 - (23%)
Similarity:	215/498 - (43%)	Gaps:	115/498 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 DRLERPITYSET----------------GQRLPVDVYMRAYIYFMQNLEAHDLQFKIYALLQMRY 98
            |..:.|:|.||.                |..:||.|.::  :..:.::...|:.|.:...|:..:
Human    66 DITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQ--VESLDSISEVDMDFTMTLYLRHYW 128

  Fly    99 LDPRLNF---RNVSPKRRQPILGEEHLRNSLWMPHIFLANERDSSILGLTEKDILTSISPDGTVI 160
            .|.||:|   .|:|      :..:..|...:|:|.:|..:.:.|.|...|..:::..:.|||.|:
Human   129 KDERLSFPSTNNLS------MTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVL 187

  Fly   161 VSNRIKATLYCWLNLKKFPFDEQHCSTVLESWMYNTSELVLHWEQ-KRPITYDGALHLTEFVLQR 224
            .|.|:..|..|.::..:||.|.|.||..:||:.|...:|:|:|:: ...:..|..:.|::|::|.
Human   188 YSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQE 252

  Fly   225 SWSNETVINADLSDLRHGAFAGNYSSLSFTVHLTRVVGFYLMDYFLPSMLIVAISWVSFWLQADQ 289
            ..:.        :.|...:..|.|:.|.....|.|.:.|:|:..:.|:.|:|.:||||||:....
Human   253 FHTT--------TKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRA 309

  Fly   290 APPRITLGTSTLLTFITLASAQGKTLPKVSYIKVSEVWFLGCTIFIFGSMVEFAFVN---TIWRR 351
            .|.|:.||.:|:||..|:.:....::|:|||||..:::.....:|:|.|::|:|.||   |:..|
Human   310 VPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQER 374

  Fly   352 KKSVPVKKLNSKHILKSTLSPNLLRRRSHARSRSFSGTALHKTADTGSLGGAGFNNYLTVNLPIT 416
            |:    :||..|....|.|.|                                         |.|
Human   375 KE----QKLREKLPCTSGLPP-----------------------------------------PRT 394

  Fly   417 TIKEGQVLDQQRTSRVVQKMDVNFVESAFGSMGSAQSTGAISAASSSQTLTNNNRTESAGHQEEI 481
            .:.:|...|.          :||.:::.....|.......:....:|:..:...:::.:.:
Human   395 AMLDGNYSDG----------EVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSY---- 445

  Fly   482 DLSGWTTLTPQEIAMWIDSRA-----RFVFPLSFLVFNLFFWT 519
                        ::|.||:.|     |.:||.::::|||.:|:
Human   446 ------------VSMRIDTHAIDKYSRIIFPAAYILFNLIYWS 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:273305	115/498 (23%)
		Neur_chan_LBD	36..259	CDD:280998	54/228 (24%)
		Neur_chan_memb	270..518	CDD:280999	57/255 (22%)
GABRR1	NP_002033.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..55
		LIC	75..478	CDD:273305	112/489 (23%)
		Neur_chan_LBD	76..281	CDD:280998	51/220 (23%)
		Neur_chan_memb	288..475	CDD:280999	57/257 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810