Protein Alignment CG6927 and GABRB1

DIOPT Version :9

• Sequence 1: NP_572194.1
• Gene: CG6927 / 31419
• FlyBaseID: FBgn0029733
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_000803.2
• Gene: GABRB1 / 2560
• HGNCID: 4081
• Length: 474
• Species: Homo sapiens
• Alignment Length: 488
• Identity: 123/488 - (25%)
• Similarity: 231/488 - (47%)
• Gaps: 60/488 - (12%)

  Fly    38 QLLDRLTHGCRYDRLERPITYSETGQRLPVDVYMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPR 102
            :.:|||..|  ||...||    :.|.. ||||.||..:..:..:...::.:.:....|..:.|.|
Human    39 ETVDRLLKG--YDIRLRP----DFGGP-PVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKR 96

  Fly   103 LNFRNVSPKRRQPILGEEHLRNSLWMPHIFLANERDSSILGLTEKDILTSISPDGTVIVSNRIKA 167
            |::..:...    :..:..:.:.||:|..:..|::.|.:.|:|.|:.:..:.|||||:...||..
Human    97 LSYSGIPLN----LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITT 157

  Fly   168 TLYCWLNLKKFPFDEQHCSTVLESWMYNTSELVLHWE-QKRPITYDGALHLTEFVLQRSWSNETV 231
            |..|.::|:::|.|||:|:..:||:.|.|.::..:|. .:..:|....:.|.:|         ::
Human   158 TAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQF---------SI 213

  Fly   232 INADLSDLRHGAFAGNYSSLSFTVHLTRVVGFYLMDYFLPSMLIVAISWVSFWLQADQAPPRITL 296
            ::..:...:.....|.|..||.:..|.|.:|::::..::||.||..:||||||:..|.:..|:.|
Human   214 VDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVAL 278

  Fly   297 GTSTLLTFITLASAQGKTLPKVSYIKVSEVWFLGCTIFIFGSMVEFAFVNTIWRRKKSVPVKKLN 361
            |.:|:||..|:::...:||||:.|:|..:::.:||.:|:|.:::|:||||.|:..|.  |.||..
Human   279 GITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKG--PQKKGA 341

  Fly   362 SKHIL----KSTLSPNLLRRRSHARSRSFSGTALHKTADTGSLGGAGFNNYLTVNLPITTIKEGQ 422
            ||...    |:.|..|.::..:|       |..|..|.:        ..|..:.:..:|::.:.:
Human   342 SKQDQSANEKNKLEMNKVQVDAH-------GNILLSTLE--------IRNETSGSEVLTSVSDPK 391

  Fly   423 VLDQQRTSRVVQKMDVNFVESAFGSMGSAQSTGAISAASSSQTLTNNNRTESAGHQEEIDLSGWT 487
            .......|..:|.........|:|            .|.....:.:..|......|.::.:...|
Human   392 ATMYSYDSASIQYRKPLSSREAYG------------RALDRHGVPSKGRIRRRASQLKVKIPDLT 444

  Fly   488 TLTPQEIAMWIDSRARFVFPLSFLVFNLFFWTF 520
            .:..      ||..:|..||::|.:||:.:|.:
Human   445 DVNS------IDKWSRMFFPITFSLFNVVYWLY 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:273305	123/486 (25%)
		Neur_chan_LBD	36..259	CDD:280998	55/221 (25%)
		Neur_chan_memb	270..518	CDD:280999	65/251 (26%)
GABRB1	NP_000803.2	LIC	9..472	CDD:273305	123/488 (25%)
		Agonist binding. /evidence=ECO:0000250	120..122		0/1 (0%)
		Agonist binding. /evidence=ECO:0000250	180..182		1/1 (100%)
		Allosteric effector binding. /evidence=ECO:0000250	290..311		6/20 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810