Protein Alignment CG6927 and GABRA6

DIOPT Version :9

• Sequence 1: NP_572194.1
• Gene: CG6927 / 31419
• FlyBaseID: FBgn0029733
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_000802.2
• Gene: GABRA6 / 2559
• HGNCID: 4080
• Length: 453
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 125/556 - (22%)
• Similarity: 219/556 - (39%)
• Gaps: 154/556 - (27%)

  Fly     1 MEWSLIISILLNCLYASASALDEDCPTLDDGDSLSQ--TQLLDRLTHGCRYDRLERP-----ITY 58
            :.|..||..|.|.|    ..|:.      :|:..|:  :::||.|..|  ||...||     :|.
Human     5 LPWLCIILWLENAL----GKLEV------EGNFYSENVSRILDNLLEG--YDNRLRPGFGGAVTE 57

  Fly    59 SETGQRLPVDVYMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRLNFRNVSPKRRQPILGEEHLR 123
            .:|      |:|:.::    ..:...::::.:....:..:.|.||.|...:     .||...:|.
Human    58 VKT------DIYVTSF----GPVSDVEMEYTMDVFFRQTWTDERLKFGGPT-----EILSLNNLM 107

  Fly   124 -NSLWMPHIFLANERDSSILGLTEKDILTSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCST 187
             :.:|.|..|..|.:.|....:|..:.|..|..:||::.:.|:.....|.:.|..||.|...|..
Human   108 VSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPL 172

  Fly   188 VLESWMYNTSELVLHWEQKRPITYDGALHLTEF------VLQRSWSNETVINADLSDLRHGAFAG 246
            ...|:.|..||::..|::       |.|:..|.      :||.....:||.:..:.     :..|
Human   173 KFGSYAYPKSEIIYTWKK-------GPLYSVEVPEESSSLLQYDLIGQTVSSETIK-----SNTG 225

  Fly   247 NYSSLSFTVHLTRVVGFYLMDYFLPSMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQ 311
            .|..::...||.|.:|::::..:.|.::.|.:|.||||:..:..|.|...|.:|:||..||:.:.
Human   226 EYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISA 290

  Fly   312 GKTLPKVSYIKVSEVWFLG-CTIFIFGSMVEFAFVNTIW-------RRK------KSVPVKKLNS 362
            ..:||||||....: ||:. |..|:|.:::|||.||...       :||      .:|.:.|...
Human   291 RHSLPKVSYATAMD-WFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATE 354

  Fly   363 KHILKSTLSPNLLRRRSHARSRSFSGTALHKTADTGSLGGAGFNNYLTVNLPITTIKEGQVLDQQ 427
            ....:..|.|:   .:.|.:.|..|                       ::|||
Human   355 PLEAEIVLHPD---SKYHLKKRITS-----------------------LSLPI------------ 381

  Fly   428 RTSRVVQKMDVNFVESAFGSMGSAQSTGAISAASSSQTLTNNNRTESAGHQEEIDLSGWTTLTPQ 492
                                         :|::.:::.||.....:|            |.:||.
Human   382 -----------------------------VSSSEANKVLTRAPILQS------------TPVTPP 405

  Fly   493 EIA------MWIDSRARFVFPLSFLVFNLFFWTFVY 522
            .::      ..||..:|.:||::|..|||.:|. ||
Human   406 PLSPAFGGTSKIDQYSRILFPVAFAGFNLVYWV-VY 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:273305	123/550 (22%)
		Neur_chan_LBD	36..259	CDD:280998	52/236 (22%)
		Neur_chan_memb	270..518	CDD:280999	59/267 (22%)
GABRA6	NP_000802.2	Neur_chan_LBD	5..440	CDD:332142	123/554 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810