DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6927 and GABRA3

DIOPT Version :9

Sequence 1:	NP_572194.1	Gene:	CG6927 / 31419	FlyBaseID:	FBgn0029733	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_000799.1	Gene:	GABRA3 / 2556	HGNCID:	4077	Length:	492	Species:	Homo sapiens

Alignment Length:	510	Identity:	130/510 - (25%)
Similarity:	219/510 - (42%)	Gaps:	97/510 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DCPTLDDGDSLS-QTQLLDRLTHGCRYDRLERP-----ITYSETGQRLPVDVYMRAYIYFMQNLE 82
            |.|. |..|::: .|::||||..|  ||...||     :|..:|      |:|:.::    ..:.
Human    55 DIPD-DSTDNITIFTRILDRLLDG--YDNRLRPGLGDAVTEVKT------DIYVTSF----GPVS 106

  Fly    83 AHDLQFKIYALLQMRYLDPRLNFRNVSPKRRQPILGEEHLRNSLWMPHIFLANERDSSILGLTEK 147
            ..|:::.|....:..:.|.||.|.  .|.:..|:  ...|.:.:|.|..|..|.:.|....:|..
Human   107 DTDMEYTIDVFFRQTWHDERLKFD--GPMKILPL--NNLLASKIWTPDTFFHNGKKSVAHNMTTP 167

  Fly   148 DILTSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCSTVLESWMYNTSELVLHW----EQKRP 208
            :.|..:..:||::.:.|:.....|.::|:.||.|...|.....|:.|.|:|:|..|    .:...
Human   168 NKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVE 232

  Fly   209 ITYDGALHLTEFVLQRSWSNETVINADLSDLRHGAFAGNYSSLSFTVHLTRVVGFYLMDYFLPSM 273
            :..||: .|.::.|........:|.:.         .|.|..::...||.|.:|::::..:||.:
Human   233 VAQDGS-RLNQYDLLGHVVGTEIIRSS---------TGEYVVMTTHFHLKRKIGYFVIQTYLPCI 287

  Fly   274 LIVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQGKTLPKVSYIKVSEVWFLG-CTIFIFG 337
            :.|.:|.|||||..:..|.|...|.:|:||..||:.:...:||||:|....: ||:. |..|:|.
Human   288 MTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMD-WFIAVCYAFVFS 351

  Fly   338 SMVEFAFVNTIWRRKKSVPVKKLNSKHILKSTLSPNLLRRRSHARSRSFSGTALHKTADTGSLGG 402
            :::|||.||...:|..:...||:           |..|..:     :........||:.|.::.|
Human   352 ALIEFATVNYFTKRSWAWEGKKV-----------PEALEMK-----KKTPAAPAKKTSTTFNIVG 400

  Fly   403 AGFNNYLTVNLPITTIKEGQVLDQQRTSRVVQKMDVNFVESAFGSMGSAQSTGAISAASSSQTLT 467
            ..:        ||...|                 |..|...:.|:..||.||..| .||...|..
Human   401 TTY--------PINLAK-----------------DTEFSTISKGAAPSASSTPTI-IASPKATYV 439

  Fly   468 NNNRTESAGHQEEIDLSGWTTLTPQEIAMWIDSRARFVFPLSFLVFNLFFW-TFV 521
            .::.||              |.|...::. :|..:|.:||:.|.:|||.:| |:|
Human   440 QDSPTE--------------TKTYNSVSK-VDKISRIIFPVLFAIFNLVYWATYV 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:273305	128/507 (25%)
		Neur_chan_LBD	36..259	CDD:280998	54/231 (23%)
		Neur_chan_memb	270..518	CDD:280999	67/248 (27%)
GABRA3	NP_000799.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..54
		LIC	69..478	CDD:273305	123/492 (25%)
		LGIC_ECD_GABAAR_A3	75..274	CDD:349837	49/224 (22%)
		Cys-loop	191..205	CDD:349837	5/13 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810