Protein Alignment CG6927 and Glrb

DIOPT Version :10

• Sequence 1: NP_572194.1
• Gene: CG6927 / 31419
• FlyBaseID: FBgn0029733
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_445748.1
• Gene: Glrb / 25456
• RGDID: 2706
• Length: 496
• Species: Rattus norvegicus
• Alignment Length: 579
• Identity: 150/579 - (25%)
• Similarity: 246/579 - (42%)
• Gaps: 146/579 - (25%)

  Fly     1 MEWSLIIS--ILLNCLYASASALDED------------CPTLDDGDSL------SQTQLLDRLTH 45
            |::||.:|  ||::.|:..|.:.::.            ||:....:.|      |.:.:|:||.
  Rat     1 MKFSLAVSFFILMSLLFEDACSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPPNSTSNILNRLL- 64

  Fly    46 GCRYDRLERPITYSETGQRLPVDVYMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRL----NFR 106
             ..||...||     ..:.:||||.:..:|....:::...:.:::...|:.::.||||    :||
  Rat    65 -VSYDPRIRP-----NFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFR 123

  Fly   107 NVSPKRRQPILGEEHLRNSLWMPHIFLANERDSSILGLTEKDILTSISPDGTVIVSNRIKATLYC 171
            ........|.     :...||.|.:|.|||:.::...:|:::||..|..||.|:||.|:..||.|
  Rat   124 GSDALTVDPT-----MYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSC 183

  Fly   172 WLNLKKFPFDEQHCSTVLESWMYNTSELVLHWEQKRPITYDGALHLTEFVLQRSWSNETVINADL 236
            .|:|..||.|.|.|...|||:.|.|.:|...|:...|:..: .:.|.:|.:::
  Rat   184 PLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLE-KIALPQFDIKK------------ 235

  Fly   237 SDLRHG------AFAGNYSSLSFTVHLTRVVGFYLMDYFLPSMLIVAISWVSFWLQADQAPPRIT 295
            .|:.:|      ...|.|:.:.....|.|.||||:|..:.|::|||.:||:|||:..|.:..|:.
  Rat   236 EDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVP 300

  Fly   296 LGTSTLLTFITLASAQGKTLPKVSYIKVSEVWFLGCTIFIFGSMVEFAFVNTIWRRKKSVPVKKL 360
            ||..::|:..:..:.....||||||:|..:||.:.|.:|.|.|:||:|.|..:....|.|..:|
  Rat   301 LGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEK- 364

  Fly   361 NSKHILKSTLSPNLLRRRSHARSRSFSGTALHKTADTGSLGGAGFNNYLTVN-----LPITTIKE 420
                                ||      .|..:.|| |..|.|...|  |||     :.|:|::.
  Rat   365 --------------------AR------IAKAEQAD-GKGGNAAKKN--TVNGTGTPVHISTLQV 400

  Fly   421 GQVLDQQRTSRVVQKMDVNFVESAFGSMGSAQSTGAISAASSSQTLTNNNRTESAGHQEEIDLSG 485
            |:.    |..:|                           .:|...|.:|:.:.......:.:||.
  Rat   401 GET----RCKKV---------------------------CTSKSDLRSNDFSIVGSLPRDFELSN 434

  Fly   486 WTTL-TPQEI------------------------AMWIDSRARFVFPLSFLVFNLFFWT 519
            :... .|.|:                        |..||..||.:||..||.||:.:|:
  Rat   435 YDCYGKPIEVNNGLGKPQAKNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWS 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:455710	149/577 (26%)
Glrb	NP_445748.1	LIC	43..495	CDD:455710	140/537 (26%)
		LGIC_ECD_GlyR_beta	79..265	CDD:349811	55/203 (27%)
		Cys-loop	183..197	CDD:349811	7/13 (54%)