DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6927 and Glra2

DIOPT Version :9

Sequence 1:	NP_572194.1	Gene:	CG6927 / 31419	FlyBaseID:	FBgn0029733	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_036700.1	Gene:	Glra2 / 24397	RGDID:	2705	Length:	452	Species:	Rattus norvegicus

Alignment Length:	498	Identity:	136/498 - (27%)
Similarity:	222/498 - (44%)	Gaps:	112/498 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SLSQTQLLDRL---THGCRYDRLERPITYSETGQRLPVDVYMRAYIYFMQNLEAHDLQFKIYALL 94
            :||.:..||:|   |.|  ||...||     ..:..||:|....:|....::....:.:::...|
  Rat    41 TLSPSDFLDKLMGRTSG--YDARIRP-----NFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFL 98

  Fly    95 QMRYLDPRLNFR-------NVSPKRRQPILGEEHLRNSLWMPHIFLANERDSSILGLTEKDILTS 152
            :.::.|.||.:.       ::.|.          :.:|:|.|.:|.|||:.::...:|..:.|..
  Rat    99 RQQWNDSRLAYSEYPDDSLDLDPS----------MLDSIWKPDLFFANEKGANFHDVTTDNKLLR 153

  Fly   153 ISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCSTVLESWMYNTSELVLHWEQKRPITYDGALHL 217
            ||.:|.|:.|.|:..||.|.::||.||.|.|.|:..|||:.|..::|:..|....|:.....|.|
  Rat   154 ISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTL 218

  Fly   218 TEFVLQRSWSNETVINADLSDLRHGAFAGNYSSLSFTVHLTRVVGFYLMDYFLPSMLIVAISWVS 282
            .:|:|:.        ..:|.........|.::.:....||.|.:|:||:..::||:|||.:||||
  Rat   219 PQFILKE--------EKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVS 275

  Fly   283 FWLQADQAPPRITLGTSTLLTFITLASAQGKTLPKVSYIKVSEVWFLGCTIFIFGSMVEFAFVNT 347
            ||:..|.||.|:.||.:|:||..|.:|....:||||||:|..::|...|.:|:|.:::|:|.||.
  Rat   276 FWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNF 340

  Fly   348 IWRRKKSVPVKKLNSKHILKSTLSPNLLRRRSHARSRSFSGTALHKTADTGSLGGAGFNNYLTVN 412
            :.|:          .|..|:       ||||...::
  Rat   341 VSRQ----------HKEFLR-------LRRRQKRQN----------------------------- 359

  Fly   413 LPITTIKEGQVLDQQRTSRVVQKMDVNFVESAFGSMGSAQST--GAISAASSSQTLTNNNRTESA 475
                  ||..|..:.|         .||  |.:| ||.....  |....|:.:..|....:...|
  Rat   360 ------KEEDVTRESR---------FNF--SGYG-MGHCLQVKDGTAVKATPANPLPQPPKDADA 406

  Fly   476 GHQEEIDLSGWTTLTPQEIAMWIDSRARFVFPLSFLVFNLFFW 518
            ..::.:|.           |..||:.:|..|||:||:||:|:|
  Rat   407 IKKKFVDR-----------AKRIDTISRAAFPLAFLIFNIFYW 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:273305	136/498 (27%)
		Neur_chan_LBD	36..259	CDD:280998	58/232 (25%)
		Neur_chan_memb	270..518	CDD:280999	71/249 (29%)
Glra2	NP_036700.1	LIC	46..441	CDD:273305	134/493 (27%)
Glra2	NP_036700.1	Strychnine-binding. /evidence=ECO:0000250\|UniProtKB:O93430	236..241		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010