Protein Alignment CG6927 and GABRR3

DIOPT Version :9

• Sequence 1: NP_572194.1
• Gene: CG6927 / 31419
• FlyBaseID: FBgn0029733
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_001099050.1
• Gene: GABRR3 / 200959
• HGNCID: 17969
• Length: 467
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 125/518 - (24%)
• Similarity: 236/518 - (45%)
• Gaps: 106/518 - (20%)

  Fly    18 ASALDEDCP----TLDDGDSLSQTQLLDRLTHGCRYDRLERPITYSETGQRLPV--DVYMRAYIY 76
            :|::.:.|.    ...|..:.::.|..::|.|....|...||   ...|..:||  ||::.:
Human    35 SSSMKQTCKQETRMKKDDSTKARPQKYEQLLHIEDNDFAMRP---GFGGSPVPVGIDVHVES--- 93

  Fly    77 FMQNLEAHDLQFKIYALLQMRYLDPRLNFRNVSPKRRQPILGEEHLRNSLWMPHIFLANERDSSI 141
             :.::...::.|.:...|:..:.|.||:|.:.:.|   .:..:..|...:|:|.||..:.:.|.|
Human    94 -IDSISETNMDFTMTFYLRHYWKDERLSFPSTANK---SMTFDHRLTRKIWVPDIFFVHSKRSFI 154

  Fly   142 LGLTEKDILTSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCSTVLESWMYNTSELVLHWEQ- 205
            ...|.::|:..:.|||.|::|.||..:..|:::..:||.|.|:||..|||:.||..:|:|:|:.
Human   155 HDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKHG 219

  Fly   206 KRPITYDGALHLTEFVLQRSWSNETVINADLSDLRHGAF---AGNYSSLSFTVHLTRVVGFYLMD 267
            .:.:..:..:.|::|.::           |.|.....||   .|.|:.|.....|.|.|.|:::.
Human   220 NKSLNTEEHMSLSQFFIE-----------DFSASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQ 273

  Fly   268 YFLPSMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQGKTLPKVSYIKVSEVWFLGCT 332
            .:.|::|:|.:||||||:.....|.|::||.:|:||..|:.:|...::|:|||:|..:|:....:
Human   274 TYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSS 338

  Fly   333 IFIFGSMVEFAFVN---TIWRRKKSVPVKKLNSKHILKSTLSPNLLRRRSHARSRSFSGTALHKT 394
            :|:|.|::|:|.||   |:..||:.....|::..:.:.:            .::.:|.|......
Human   339 LFVFLSVIEYAAVNYLTTVEERKQFKKTGKISRMYNIDA------------VQAMAFDGCYHDSE 391

  Fly   395 ADTG----SLGGAGFNNYLTVNLPITTIKEGQVLDQQRTSRVVQKMDVNFVESAFGSMGSAQSTG 455
            .|..    ||....|....::..|.|.           :||:.::      :|..|.:|
Human   392 IDMDQTSLSLNSEDFMRRKSICSPSTD-----------SSRIKRR------KSLGGHVG------ 433

  Fly   456 AISAASSSQTLTNNNRTESAGHQEEIDLSGWTTLTPQEIAMWIDSRARFVFPLSFLVFNLFFW 518
                    :.:..||..                         ||:.:|.:||:.:::||||:|
Human   434 --------RIILENNHV-------------------------IDTYSRILFPIVYILFNLFYW 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:273305	125/518 (24%)
		Neur_chan_LBD	36..259	CDD:280998	59/228 (26%)
		Neur_chan_memb	270..518	CDD:280999	59/254 (23%)
GABRR3	NP_001099050.1	LIC	55..466	CDD:273305	122/498 (24%)
		Neur_chan_LBD	59..267	CDD:280998	60/228 (26%)
		Neur_chan_memb	274..463	CDD:280999	59/256 (23%)
		Interaction with SQSTM1. /evidence=ECO:0000250	347..448		25/168 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810