DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6927 and lgc-57

DIOPT Version :9

Sequence 1:	NP_572194.1	Gene:	CG6927 / 31419	FlyBaseID:	FBgn0029733	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_496306.2	Gene:	lgc-57 / 191636	WormBaseID:	WBGene00001586	Length:	473	Species:	Caenorhabditis elegans

Alignment Length:	530	Identity:	132/530 - (24%)
Similarity:	230/530 - (43%)	Gaps:	92/530 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LIISILLNCLYASAS--ALDEDCPTLDDGDSLSQ-TQLLDRLTHGCRYDRLERPITYSETGQRLP 66
            ::|..|:.|:...|.  ..||:...:::...:.. |::|.|:.:   |:|...|:    ..|.|.
Worm     8 ILIYSLMQCVLGQAEFWDYDENVTQIEEDFKIDDVTRILKRVGN---YNRNAYPL----LDQDLA 65

  Fly    67 VDVYMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRLNFRNVSPKRRQPILGEEHLRNSLWMPHI 131
            ..|.::.||..|.:..|..:.|::....|.:::|.||...|.    ::.::.:..|...||.|.:
Worm    66 THVDIQMYIEGMSSFHAQSMDFQVDIYFQEKWVDHRLQHNNT----KRILVKDPKLFGLLWHPDL 126

  Fly   132 FLANERDSSILGLTEKDILTSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCSTVLESWMYNT 196
            :.||.|.:|...:|:.:.|..|.|:|||....||..|:.|..:|.::|.|.|:|...:.|:.|:.
Worm   127 YFANARTASFHDVTQPNFLVWIYPNGTVWYDCRISLTVLCMQDLARYPLDSQNCGLRILSYAYDE 191

  Fly   197 SELVLHWEQKRPITYDGALHLTEFVLQRSWSNETVINADLSDLRHGAF--------AGNYSSLSF 253
            .:|::.|....|:..:..:.:.:.                 .|:|..|        .|.:||...
Worm   192 EQLIIRWNGGNPVEVNRGIRMPDM-----------------HLKHIKFYTKRDKYATGIWSSAVA 239

  Fly   254 TVHLTRVVGFYLMDYFLPSMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQGKTLPKV 318
            ..|:.|.:..:::..::|:.|||.|||.||||..:..|.|::|..:||||..|.:||....||:.
Worm   240 EFHVDREITHHIIQSYIPTSLIVIISWFSFWLDVEAVPGRVSLSITTLLTLATQSSAARMALPQA 304

  Fly   319 SYIKVSEVWFLGCTIFIFGSMVEFAFVNTIWRRKKSVPVKKLNSKHILKSTLSPNLLRRRSHARS 383
            |.:|..:||...|..|:|.:|:||..||...|||             :::.:.|..|..:.|...
Worm   305 SDVKAIDVWMGTCMAFVFSAMIEFTVVNYCVRRK-------------VRTKIKPRGLSEQVHDMV 356

  Fly   384 RSFSGTALHKTADTGSLGGAGFNNYLTVNLPITTIKEGQVLDQQRTSRVVQKMDVNFVESAFGSM 448
            ..:     .:..|.       |||      ....|.....|.....:..||:   ||.:.....|
Worm   357 AQY-----REKKDK-------FNN------GNCEISYEMALQPNEDNATVQR---NFEKKEVREM 400

  Fly   449 GSAQ--STGAISAASSSQTLTNN-NRTESAGHQEEIDLSGWTTLTPQEIAMWIDSRARFVFPLSF 510
            ..|.  ...::...|..:|:.:. ||.|.                .::.|..||..:|.:|||:|
Worm   401 NQASLFVRRSLLPTSKRKTIEDRINRVEE----------------NRKNAQKIDRYSRALFPLAF 449

  Fly   511 LVFNLFFWTF 520
            ::||:|:|.:
Worm   450 IIFNIFYWIY 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:273305	132/528 (25%)
		Neur_chan_LBD	36..259	CDD:280998	55/231 (24%)
		Neur_chan_memb	270..518	CDD:280999	69/250 (28%)
lgc-57	NP_496306.2	Neur_chan_LBD	43..217	CDD:280998	48/201 (24%)
		LIC	44..460	CDD:273305	125/494 (25%)
		Neur_chan_memb	255..457	CDD:280999	69/251 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910