Protein Alignment CG6927 and lgc-50

DIOPT Version :10

• Sequence 1: NP_572194.1
• Gene: CG6927 / 31419
• FlyBaseID: FBgn0029733
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_498637.3
• Gene: lgc-50 / 188633
• WormBaseID: WBGene00020605
• Length: 491
• Species: Caenorhabditis elegans
• Alignment Length: 543
• Identity: 137/543 - (25%)
• Similarity: 227/543 - (41%)
• Gaps: 92/543 - (16%)

  Fly     9 ILLNCLYASASALDEDCPTLDDGDSLSQTQLLDRLTHGCRYDRLERPITYSETGQRLP----VDV 69
            ::|..::...||...:.|.....:|::..:|:|.|            :|..:| ..||    |:|
 Worm     5 LVLQLVFFYFSAATTNSPKKCSRNSINLGKLIDTL------------LTDYDT-HLLPEAEGVNV 56

  Fly    70 YMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRLNFRNVSPKRRQPILGEEHLRNSLWMPHIFLA 134
            .:..::..:..:......|.:..:....:.||||:|::::.......| :...|..:|.|...:.
 Worm    57 TIELHVQGVSGISEITGDFSLDVMYSEIWQDPRLSFKHLNVCATNITL-KSDFRKKIWTPDTCII 120

  Fly   135 NERDSSILGLTEKDILTSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCSTVLESWMYNTSEL 199
            |.:.|||.....::....:..:|.|..:.|:.....|.:|||.||||...|..||||:.:||.|:
 Worm   121 NSKSSSIHSSPSENTFVILYENGLVWSNFRLNVKTPCSVNLKMFPFDSLSCEIVLESYSFNTDEV 185

  Fly   200 VLHWEQKRPITYDGALHLTEFVLQRSWSNETVINADLSDLRHGAFAGNYSSLSFTVHLTRVVGFY 264
            .|.|... |||....:.|.:|.| ..||      .|...|.:.....:.:.:.||  ..|..|||
 Worm   186 RLMWHDV-PITMMEKVELPDFDL-IGWS------TDHQRLEYPNGIWDRAKVKFT--FARRYGFY 240

  Fly   265 LMDYFLPSMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQGKTLPKVSYIKVSEVWFL 329
            |...:.|:.|.|..|||.|:........|||||.|:||..........:.||:|||||..:||.:
 Worm   241 LFQSYFPTSLTVISSWVGFFFDVRSVSARITLGVSSLLALTFQFGNVLRHLPRVSYIKCLDVWMI 305

  Fly   330 GCTIFIFGSMVEFAFVNTI--WRRKKSVPVKKLNSKHILKSTLSPNLLRRRSHARSRSFSGTALH 392
            ...||||.::||.|.|..:  |.|::.:..|.|.  |.|      |.:|:.....|:
 Worm   306 FSVIFIFCTLVELAIVCQLNRWERERQIGSKVLG--HWL------NQIRKTRKKESK-------- 354

  Fly   393 KTADTGSLGGAGFNNYLTVNLPITTIKEGQVLDQQ-----RTSRVVQKMDVNFVESAFGSMGSAQ 452
              ||.|  ||.|....|...:|:....:....|..     ..:..:|..:.|.
 Worm   355 --ADEG--GGGGVGGLLRKRIPVLAQLKAAATDSNSGAATAMTTAIQPPNTNL------------ 403

  Fly   453 STGAISAASSSQTLTNNNRT---ESAGHQEEIDLS---------------GWTTLTPQEIAMWID 499
              .:|:.:.:|:.:.||..:   |:..::::...|               .||..:.|     :|
 Worm   404 --NSITNSDNSKLVANNFTSIEHETYAYEKKRGFSHCFQRFVYAICPPDRDWTITSVQ-----VD 461

  Fly   500 SRARFVFPLSFLVFNLFFWTFVY 522
            ..:..:||||||:||:.:|:..:
 Worm   462 RCSMIMFPLSFLIFNVVYWSIYF 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:455710	137/539 (25%)
lgc-50	NP_498637.3	LIC	34..483	CDD:455710	132/511 (26%)
		LGIC_ECD_GABAAR	54..236	CDD:349791	49/192 (26%)
		Cys-loop	157..171	CDD:349791	8/13 (62%)