Protein Alignment CG6927 and acc-4

DIOPT Version :10

• Sequence 1: NP_572194.1
• Gene: CG6927 / 31419
• FlyBaseID: FBgn0029733
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_001407497.1
• Gene: acc-4 / 176778
• WormBaseID: WBGene00012099
• Length: 409
• Species: Caenorhabditis elegans
• Alignment Length: 539
• Identity: 124/539 - (23%)
• Similarity: 205/539 - (38%)
• Gaps: 166/539 - (30%)

  Fly     5 LIISILLNCLYASASALDED-------CPTLDD------------GDSLSQTQLLDRLTHGCRYD 50
            |:||||::...:...:|::|       ||....            ||.....|:||      .|:
 Worm     6 LVISILISNAGSLLRSLEDDSNECMFNCPKRARNVSVPHTEKTCMGDDAIIAQILD------GYN 64

  Fly    51 RLERPITYSETGQRLPVDVYMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRLNFRNVSPKRRQP 115
            :|:.|     .|..:.|.:  ..::..:..:.....:|::...:..|:.||.|.:.:::|.:...
 Worm    65 KLDLP-----GGGHVVVSI--EIWVQEVSKIIEITSEFELDIYVTERWTDPSLAYSHLNPCKSNM 122

  Fly   116 ILGEEHLRNSLWMPHIFLANERDSSILGLTEKDILTSISPDGTVIVSNRIKATLYCWLNLKKFPF 180
            .:....:.|.:|.||....|.:.::|.....|:|...|..:|::..:.|||.|..|...|:.||.
 Worm   123 SVDGATILNKIWNPHACFVNSKLANIHESPFKNIFLQIYSNGSIWHNYRIKLTGPCSSTLRTFPI 187

  Fly   181 DEQHCSTVLESWMYNTSELVLHW-EQKRPIT-YDGALHLTEFVLQRSWSNETVINADLSDLRHGA 243
            |:|.|....||:.:||.::.:.| ....||| ..|.:.|.::||        |..:..|:||...
 Worm   188 DQQRCMLFYESFTHNTDQVKMEWITTVPPITILKGNITLPDYVL--------VDFSSSSELRLYP 244

  Fly   244 FAGNYSSLSFTVHLTRVVGFYLMDYFLPSMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITLA 308
             .|.::.|..|....|:.|||::..::|:.:.|.||||||.|.|:|.|.|.|:|.::||......
 Worm   245 -PGIFNELIATFTFQRLYGFYILQVYVPAYISVFISWVSFTLGAEQIPSRTTVGVNSLLALTFQF 308

  Fly   309 SAQGKTLPKVSYIKVSEVWFLGCTIFIFGSMVEFAFVNTIWRRKKSVPVKKLNSKHILKSTLSPN 373
            .|....|||.|.:|..:||.|....|||.|::|.|.|
 Worm   309 GAVVNNLPKTSDVKAIDVWILSSMAFIFASLIELAVV---------------------------- 345

  Fly   374 LLRRRSHARSRSFSGTALHKTADTGSLGGAGFNNYLTVNLPITTIKEGQVLDQQRTSRVVQKMDV 438
                                             .||:        ::||
 Worm   346 ---------------------------------GYLS--------RDGQ---------------- 353

  Fly   439 NFVESAFGSMGSAQSTGAISAASSSQTLTNNNRTESAGHQEEIDLSGWTTLTPQEIAMWIDSRAR 503
                           .|:|....|...:               :...||       |:.||..:.
 Worm   354 ---------------HGSIKCRCSWLCM---------------NCKDWT-------ALKIDQMSS 381

  Fly   504 FVFPLSFLVFNLFFWTFVY 522
            .|||:|||.||:::| |::
 Worm   382 IVFPVSFLAFNIWYW-FIF 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:455710	123/535 (23%)
acc-4	NP_001407497.1	LGIC_ECD_GABAAR	74..259	CDD:349791	47/195 (24%)
		Cys-loop	178..192	CDD:349791	6/13 (46%)
		LGIC_TM_anion	263..396	CDD:349851	55/254 (22%)
		TM1 helix	263..286	CDD:349851	10/22 (45%)
		TM2 helix	290..314	CDD:349851	7/23 (30%)
		TM3 helix	322..348	CDD:349851	11/86 (13%)
		TM4 helix	349..396	CDD:349851	18/107 (17%)