DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6927 and Glra1

DIOPT Version :9

Sequence 1:	NP_572194.1	Gene:	CG6927 / 31419	FlyBaseID:	FBgn0029733	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001277750.1	Gene:	Glra1 / 14654	MGIID:	95747	Length:	457	Species:	Mus musculus

Alignment Length:	537	Identity:	150/537 - (27%)
Similarity:	244/537 - (45%)	Gaps:	115/537 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WSLIISILLNCLYASASALDEDCPTLDDGDSLSQTQLLDRL---THGCRYDRLERPITYSETGQR 64
            |..|:...|.....:.:|.....|       :|.:..||:|   |.|  ||...||     ..:.
Mouse    12 WETIVFFSLAASKEAEAARSAPKP-------MSPSDFLDKLMGRTSG--YDARIRP-----NFKG 62

  Fly    65 LPVDVYMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRLNFRNVSPKRRQPILGEEHLRNSLWMP 129
            .||:|....:|....::....:.:::...|:.::.||||.: |..|.....:  :..:.:|:|.|
Mouse    63 PPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAY-NEYPDDSLDL--DPSMLDSIWKP 124

  Fly   130 HIFLANERDSSILGLTEKDILTSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCSTVLESWMY 194
            .:|.|||:.:....:|..:.|..||.:|.|:.|.||..||.|.::||.||.|.|.|...|||:.|
Mouse   125 DLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGY 189

  Fly   195 NTSELVLHWEQKRPITYDGALHLTEFVLQRSWSNETVINADLSDLRHGA---FAGNYSSLSFTVH 256
            ..::|:..|:::..:.....|.|.:|:|:..           .|||:..   ..|.::.:....|
Mouse   190 TMNDLIFEWQEQGAVQVADGLTLPQFILKEE-----------KDLRYCTKHYNTGKFTCIEARFH 243

  Fly   257 LTRVVGFYLMDYFLPSMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQGKTLPKVSYI 321
            |.|.:|:||:..::||:|||.:||:|||:..|.||.|:.||.:|:||..|.:|....:||||||:
Mouse   244 LERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYV 308

  Fly   322 KVSEVWFLGCTIFIFGSMVEFAFVNTIWRRKKSVPVKKLNSKHILKSTLSPNLLRRRSHARSRSF 386
            |..::|...|.:|:|.:::|:|.||.:.|:          .|.:|:      ..|:|.|.:|
Mouse   309 KAIDIWMAVCLLFVFSALLEYAAVNFVSRQ----------HKELLR------FRRKRRHHKS--- 354

  Fly   387 SGTALHKTADTGSLGGAGFNNYLTVNLPITTIKEGQVLDQQRTSRVVQKMDVNFVESAFGSMGSA 451
              ..|:...|  ..||.|..|:                                  ||:| ||.|
Mouse   355 --PMLNLFQD--DEGGEGRFNF----------------------------------SAYG-MGPA 380

  Fly   452 --QSTGAISAASSSQTLTNNNRTESAGHQEEIDLSGWTTLTPQEI-------AMWIDSRARFVFP 507
              |:...||...::    |||.|.......:         :|:|:       |..||..:|..||
Mouse   381 CLQAKDGISVKGAN----NNNTTNPPPAPSK---------SPEEMRKLFIQRAKKIDKISRIGFP 432

  Fly   508 LSFLVFNLFFWTFVYCI 524
            ::||:||:|:| .:|.|
Mouse   433 MAFLIFNMFYW-IIYKI 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:273305	148/531 (28%)
		Neur_chan_LBD	36..259	CDD:280998	62/228 (27%)
		Neur_chan_memb	270..518	CDD:280999	75/256 (29%)
Glra1	NP_001277750.1	LIC	7..446	CDD:273305	148/533 (28%)
		Strychnine-binding. /evidence=ECO:0000250\|UniProtKB:O93430	230..235		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..410		4/31 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910