Protein Alignment CG6927 and Gabra6

DIOPT Version :10

• Sequence 1: NP_572194.1
• Gene: CG6927 / 31419
• FlyBaseID: FBgn0029733
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: XP_036012221.1
• Gene: Gabra6 / 14399
• MGIID: 95618
• Length: 459
• Species: Mus musculus
• Alignment Length: 414
• Identity: 107/414 - (25%)
• Similarity: 185/414 - (44%)
• Gaps: 70/414 - (16%)

  Fly     1 MEWSLIISILLNCLYASASALDEDCPTLDDGDSLSQ--TQLLDRLTHGCRYDRLERP-----ITY 58
            :.|..||..|.|     |.|..|     |:|:..|:  :::||.|..|  ||...||     :|.
Mouse     5 LPWLFIILWLEN-----AQAQLE-----DEGNFYSENVSRILDNLLEG--YDNRLRPGFGGAVTE 57

  Fly    59 SETGQRLPVDVYMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRLNFRNVSPKRRQPILGEEHLR 123
            .:|      |:|:.::    ..:...::::.:....:..:.|.||.|:..:     .||...:|.
Mouse    58 VKT------DIYVTSF----GPVSDVEMEYTMDVFFRQTWTDERLKFKGPA-----EILSLNNLM 107

  Fly   124 -NSLWMPHIFLANERDSSILGLTEKDILTSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCST 187
             :.:|.|..|..|.:.|....:|..:.|..:..:||::.:.|:.....|.:.|..||.|...|..
Mouse   108 VSKIWTPDTFFRNGKKSIAHNMTTPNKLFRLMQNGTILYTMRLTINADCPMRLVNFPMDGHACPL 172

  Fly   188 VLESWMYNTSELVLHWEQKRPITYDGALHLTEF------VLQRSWSNETVINADLSDLRHGAFAG 246
            ...|:.|..:|::..|::       |.|:..|.      :||.....:||.:..:.     :..|
Mouse   173 KFGSYAYPKTEIIYTWKK-------GPLYSVEVPEESSSLLQYDLIGQTVSSETIK-----SNTG 225

  Fly   247 NYSSLSFTVHLTRVVGFYLMDYFLPSMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQ 311
            .|..::...||.|.:|::::..:.|.::.|.:|.||||:..:..|.|...|.:|:||..||:.:.
Mouse   226 EYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISA 290

  Fly   312 GKTLPKVSYIKVSEVWFLG-CTIFIFGSMVEFAFVN--TIWRRKK---------SVPVKKLNSKH 364
            ..:||||||....: ||:. |..|:|.:::|||.||  |..:.:|         :.||.|..:..
Mouse   291 RHSLPKVSYATAMD-WFIAVCFAFVFSALIEFAAVNYFTNLQSQKAERQAQTAATPPVAKSKASE 354

  Fly   365 ILKS----TLSPNLLRRRSHARSR 384
            .|::    |..|...|||...|.|
Mouse   355 SLQAEIVVTAPPQKRRRRRRRRRR 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6927	NP_572194.1	LIC	3..520	CDD:455710	107/412 (26%)
Gabra6	XP_036012221.1	LGIC_ECD_GABAAR_A6	42..239	CDD:349840	47/225 (21%)
		Cys-loop	156..170	CDD:349840	5/13 (38%)
		LGIC_TM_GABAAR_alpha	242..337	CDD:349854	33/95 (35%)
		TM1 helix	242..265	CDD:349854	7/22 (32%)
		TM2 helix	269..293	CDD:349854	8/23 (35%)
		TM3 helix	301..327	CDD:349854	10/26 (38%)